PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1940611-9 1991 However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced. Zidovudine 123-126 interleukin 1 alpha Homo sapiens 28-41 1493577-0 1992 [Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)]. Zidovudine 86-100 interleukin 1 alpha Homo sapiens 40-53 1493577-0 1992 [Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)]. Zidovudine 102-105 interleukin 1 alpha Homo sapiens 40-53 1493577-4 1992 Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT. Zidovudine 260-263 interleukin 1 alpha Homo sapiens 47-66 1493577-4 1992 Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT. Zidovudine 260-263 interleukin 1 alpha Homo sapiens 68-78 1493577-6 1992 The results demonstrate that marrow progenitors respond differently to AZT and point out the potential efficacy of IL-1 alpha to enhance the proliferation of hematopoietic stem cells treated with growth factors (IL-3, erythropoietin) and to minimize the hematopoietic toxicity associated with AZT treatment. Zidovudine 293-296 interleukin 1 alpha Homo sapiens 115-125 1940611-6 1991 We report the results of further studies designed to investigate the ability of GM-CSF, erythropoietin, interleukin-1, and lithium to modulate AZT toxicity on murine hematopoietic granulocyte-macrophage (CFU-GM), megakaryocytic (CFU-Meg), and erythroid (BFU-E) progenitors cultured from bone marrow and spleen cells from mice infected with RLV. Zidovudine 143-146 interleukin 1 alpha Homo sapiens 104-117 1940611-9 1991 However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced. Zidovudine 123-126 interleukin 1 alpha Homo sapiens 61-71 1940611-10 1991 These results further demonstrate interleukin-1 and lithium are effective in modulating the toxic action of AZT on hematopoietic progenitors and that RLV-infected animals serve as a useful viral model system to study the effect of agents capable of modulating hematopoiesis in the presence of the anti-viral drug AZT. Zidovudine 108-111 interleukin 1 alpha Homo sapiens 34-47 7979221-0 1994 Cytokine expression in the muscle of HIV-infected patients: evidence for interleukin-1 alpha accumulation in mitochondria of AZT fibers. Zidovudine 125-128 interleukin 1 alpha Homo sapiens 73-92 2813453-4 1989 We report here the ability of recombinant human IL-1 alpha to protect normal murine hematopoietic progenitors (CFU-GM, BFU-E, and CFU-Meg) from the toxic effects of AZT. Zidovudine 165-168 interleukin 1 alpha Homo sapiens 48-58 9292697-2 1997 In zidovudine-induced myopathy and dermatomyositis, immunoreactivity for interleukin (IL)-1 has been reported in diseased muscle fibers involving myofibrillar breakdown and atrophy. Zidovudine 3-13 interleukin 1 alpha Homo sapiens 73-91 2350446-0 1990 Zidovudine inhibits functional extracellular monocytic interleukin-1. Zidovudine 0-10 interleukin 1 alpha Homo sapiens 55-68 2350446-3 1990 The present study demonstrates that zidovudine inhibits the extracellular release of IL-1 activity without affecting the generation of intracellular IL-1 or the amount of released IL-1 beta protein. Zidovudine 36-46 interleukin 1 alpha Homo sapiens 85-89 2350446-5 1990 Since IL-1 may upregulate the expression of HIV genes in infected cells, the inhibitory effect of zidovudine on the release of functional IL-1 may be relevant for the beneficial effect of the drug in HIV infection. Zidovudine 98-108 interleukin 1 alpha Homo sapiens 138-142 7498365-0 1995 Azidothymidine and interferon-alpha in vitro effects on hematopoiesis: protective in vitro activity of IL-1 and GM-CSF. Zidovudine 0-14 interleukin 1 alpha Homo sapiens 103-107 7979221-6 1994 Immunoelectron microscopy showed that interleukin-1 alpha was mainly bound to mitochondrial membranes in AZT fibers. Zidovudine 105-108 interleukin 1 alpha Homo sapiens 38-57