PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9292697-2	1997	In zidovudine-induced myopathy and dermatomyositis, immunoreactivity for interleukin (IL)-1 has been reported in diseased muscle fibers involving myofibrillar breakdown and atrophy.	Zidovudine	3-13	interleukin 1 alpha	Homo sapiens	73-91	
1940611-9	1991	However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced.	Zidovudine	123-126	interleukin 1 alpha	Homo sapiens	28-41	
1493577-0	1992	[Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)].	Zidovudine	86-100	interleukin 1 alpha	Homo sapiens	40-53	
1493577-0	1992	[Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)].	Zidovudine	102-105	interleukin 1 alpha	Homo sapiens	40-53	
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	Zidovudine	260-263	interleukin 1 alpha	Homo sapiens	47-66	
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	Zidovudine	260-263	interleukin 1 alpha	Homo sapiens	68-78	
1493577-6	1992	The results demonstrate that marrow progenitors respond differently to AZT and point out the potential efficacy of IL-1 alpha to enhance the proliferation of hematopoietic stem cells treated with growth factors (IL-3, erythropoietin) and to minimize the hematopoietic toxicity associated with AZT treatment.	Zidovudine	293-296	interleukin 1 alpha	Homo sapiens	115-125	
1940611-6	1991	We report the results of further studies designed to investigate the ability of GM-CSF, erythropoietin, interleukin-1, and lithium to modulate AZT toxicity on murine hematopoietic granulocyte-macrophage (CFU-GM), megakaryocytic (CFU-Meg), and erythroid (BFU-E) progenitors cultured from bone marrow and spleen cells from mice infected with RLV.	Zidovudine	143-146	interleukin 1 alpha	Homo sapiens	104-117	
7498365-0	1995	Azidothymidine and interferon-alpha in vitro effects on hematopoiesis: protective in vitro activity of IL-1 and GM-CSF.	Zidovudine	0-14	interleukin 1 alpha	Homo sapiens	103-107	
7979221-0	1994	Cytokine expression in the muscle of HIV-infected patients: evidence for interleukin-1 alpha accumulation in mitochondria of AZT fibers.	Zidovudine	125-128	interleukin 1 alpha	Homo sapiens	73-92	
7979221-6	1994	Immunoelectron microscopy showed that interleukin-1 alpha was mainly bound to mitochondrial membranes in AZT fibers.	Zidovudine	105-108	interleukin 1 alpha	Homo sapiens	38-57	
1940611-9	1991	However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced.	Zidovudine	123-126	interleukin 1 alpha	Homo sapiens	61-71	
1940611-10	1991	These results further demonstrate interleukin-1 and lithium are effective in modulating the toxic action of AZT on hematopoietic progenitors and that RLV-infected animals serve as a useful viral model system to study the effect of agents capable of modulating hematopoiesis in the presence of the anti-viral drug AZT.	Zidovudine	108-111	interleukin 1 alpha	Homo sapiens	34-47	
2350446-0	1990	Zidovudine inhibits functional extracellular monocytic interleukin-1.	Zidovudine	0-10	interleukin 1 alpha	Homo sapiens	55-68	
2350446-3	1990	The present study demonstrates that zidovudine inhibits the extracellular release of IL-1 activity without affecting the generation of intracellular IL-1 or the amount of released IL-1 beta protein.	Zidovudine	36-46	interleukin 1 alpha	Homo sapiens	85-89	
2350446-5	1990	Since IL-1 may upregulate the expression of HIV genes in infected cells, the inhibitory effect of zidovudine on the release of functional IL-1 may be relevant for the beneficial effect of the drug in HIV infection.	Zidovudine	98-108	interleukin 1 alpha	Homo sapiens	138-142	
2813453-4	1989	We report here the ability of recombinant human IL-1 alpha to protect normal murine hematopoietic progenitors (CFU-GM, BFU-E, and CFU-Meg) from the toxic effects of AZT.	Zidovudine	165-168	interleukin 1 alpha	Homo sapiens	48-58