PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21461578-5	2011	AZT induced concentration-dependent cell death, involving both caspase-3 and -7 and poly(ADP-ribose) polymerase activation, coupled with increased mitochondrial ROS generation in human cardiomyocytes.	Zidovudine	0-3	caspase 3	Homo sapiens	63-79	
29910624-11	2018	Conclusion: The present results show that AZT could increase the sensitization of As2O3 for inhibiting proliferation and promoting apoptosis of HepG2 cells through regulating the expression of Egr-1, which may control the expression of p53 and caspase-3.	Zidovudine	42-45	caspase 3	Homo sapiens	244-253	
27496003-7	2016	However, spontaneous apoptosis, indicated by upregulation of caspase-3 was greater in ZDV-exposed T cells.	Zidovudine	86-89	caspase 3	Homo sapiens	61-70	
21502917-10	2011	The results showed that the growth inhibitory and apoptotic effects of As2O3 and AZT on human hepatoma cells could be related to the inhibition of telomerase and the activation of caspase 3.	Zidovudine	81-84	caspase 3	Homo sapiens	180-189	
21193030-7	2011	Furthermore, AZT+IDV treatment caused apoptosis in endothelial cells, as assessed by the expression of cytochrome c and procaspase-3 proteins.	Zidovudine	13-16	caspase 3	Homo sapiens	120-132	
20929390-6	2011	AZT, but not the other NRTIs, increased unstimulated PBMC apoptosis measured by caspase 3 activity.	Zidovudine	0-3	caspase 3	Homo sapiens	80-89	
23645216-5	2013	Cell cycle distribution, ROS level, and caspase-3 activation analyses suggest that AZT reduced the ATO-induced cytotoxic effect possibly via relative induction and diminution of cells accumulated in (G1, S) and (G2/M) phase, respectively, as well as through attenuation of ROS generation and subsequent caspase-3 inhibition.	Zidovudine	83-86	caspase 3	Homo sapiens	40-49	
23645216-5	2013	Cell cycle distribution, ROS level, and caspase-3 activation analyses suggest that AZT reduced the ATO-induced cytotoxic effect possibly via relative induction and diminution of cells accumulated in (G1, S) and (G2/M) phase, respectively, as well as through attenuation of ROS generation and subsequent caspase-3 inhibition.	Zidovudine	83-86	caspase 3	Homo sapiens	303-312	
17696246-9	2007	A certain concentration of AZT could up-regulate the expression of caspase-3 mRNA (r = 0.9969, P < 0.01), which was positively related to apoptosis rate, and could down-regulate the expression of Bcl-2 mRNA, which was negatively related to apoptosis rate (r = 0.926, P < 0.01).	Zidovudine	27-30	caspase 3	Homo sapiens	67-76