PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22543504-7 2012 Gossypol was demonstrated to exhibit competitive inhibition towards UGT-mediated AZT glucuronidation, and the inhibition kinetic parameter (K(i)) was determined to be 14.0 muM. Zidovudine 81-84 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 68-71 9660989-1 1998 Zidovudine (3"-azido-3"-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5"-diphospho-glucuronosyltransferase (UGT) enzymes. Zidovudine 0-10 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 262-265 9660989-1 1998 Zidovudine (3"-azido-3"-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5"-diphospho-glucuronosyltransferase (UGT) enzymes. Zidovudine 12-38 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 262-265 9660989-1 1998 Zidovudine (3"-azido-3"-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5"-diphospho-glucuronosyltransferase (UGT) enzymes. Zidovudine 40-43 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 262-265 34684027-3 2021 Moreover, a novel in vitro metabolic method, the Bio-PK dynamic metabolic system, was constructed and combined with a physiology-based pharmacokinetic model (PBPK) model to predict the metabolism and the drug-drug interaction (DDI) of azidothymidine (AZT) and fluconazole (FCZ) mediated by the phase II metabolic enzyme UDP-glycosyltransferase (UGT) in humans. Zidovudine 235-249 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 320-343 34684027-3 2021 Moreover, a novel in vitro metabolic method, the Bio-PK dynamic metabolic system, was constructed and combined with a physiology-based pharmacokinetic model (PBPK) model to predict the metabolism and the drug-drug interaction (DDI) of azidothymidine (AZT) and fluconazole (FCZ) mediated by the phase II metabolic enzyme UDP-glycosyltransferase (UGT) in humans. Zidovudine 235-249 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 345-348 34684027-3 2021 Moreover, a novel in vitro metabolic method, the Bio-PK dynamic metabolic system, was constructed and combined with a physiology-based pharmacokinetic model (PBPK) model to predict the metabolism and the drug-drug interaction (DDI) of azidothymidine (AZT) and fluconazole (FCZ) mediated by the phase II metabolic enzyme UDP-glycosyltransferase (UGT) in humans. Zidovudine 251-254 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 320-343 34684027-3 2021 Moreover, a novel in vitro metabolic method, the Bio-PK dynamic metabolic system, was constructed and combined with a physiology-based pharmacokinetic model (PBPK) model to predict the metabolism and the drug-drug interaction (DDI) of azidothymidine (AZT) and fluconazole (FCZ) mediated by the phase II metabolic enzyme UDP-glycosyltransferase (UGT) in humans. Zidovudine 251-254 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 345-348 32651149-3 2020 In this study, UGT activities were analyzed in liver (five lobes) and small intestine (the duodenum and six sections from the proximal jejunum to the distal ileum) using typical probe substrates of human UGTs: 7-hydroxycoumarin, estradiol, serotonin, propofol, and zidovudine. Zidovudine 265-275 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 15-18 10772627-2 2000 After absorption, AZT is rapidly metabolized into 3"-azido-3"-deoxy-5"-glucuronylthymidine by UDP-glucuronosyltransferase (UGT) enzymes. Zidovudine 18-21 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 94-121 10772627-2 2000 After absorption, AZT is rapidly metabolized into 3"-azido-3"-deoxy-5"-glucuronylthymidine by UDP-glucuronosyltransferase (UGT) enzymes. Zidovudine 18-21 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 123-126 10772627-9 2000 It remains possible that other UGT enzymes are also involved in AZT conjugation; however, the glucuronidation of AZT by UGT2B7, which is a UGT2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Zidovudine 64-67 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 31-34 10772627-9 2000 It remains possible that other UGT enzymes are also involved in AZT conjugation; however, the glucuronidation of AZT by UGT2B7, which is a UGT2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Zidovudine 113-116 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 31-34 10772627-9 2000 It remains possible that other UGT enzymes are also involved in AZT conjugation; however, the glucuronidation of AZT by UGT2B7, which is a UGT2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Zidovudine 113-116 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 31-34 34684027-0 2021 A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug-Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme. Zidovudine 150-164 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 193-196 34575401-4 2021 Human PBPK models for UGT substrates with varying extents of UGT-mediated intestinal metabolism (lorazepam, oxazepam, naloxone, zidovudine, cabotegravir, raltegravir, and dolutegravir) have demonstrated utility for predicting the extent of intestinal metabolism. Zidovudine 128-138 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 22-25 34575401-4 2021 Human PBPK models for UGT substrates with varying extents of UGT-mediated intestinal metabolism (lorazepam, oxazepam, naloxone, zidovudine, cabotegravir, raltegravir, and dolutegravir) have demonstrated utility for predicting the extent of intestinal metabolism. Zidovudine 128-138 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 61-64 30036684-4 2018 Herein, we designed and optimized a validated cocktail method for the simultaneous evaluation of drug-mediated inhibition of the main five UGT isoforms using respective specific probe substrates (estradiol for UGT1A1, chenodeoxycholic acid for UGT1A3, serotonin for UGT1A6, propofol for UGT1A9/PROG and zidovudine for UGT2B7/AZTG) in human and rat liver microsomes by liquid chromatography-tandem mass spectrometry (LCMS/MS). Zidovudine 303-313 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 139-142 16542204-1 2006 AIMS: Using the fluconazole-zidovudine (AZT) interaction as a model, to determine whether inhibition of UDP-glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could be predicted quantitatively from in vitro kinetic data generated in the presence and absence bovine serum albumin (BSA). Zidovudine 28-38 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 104-131 19475557-8 2010 Coexpression of the UGT1As significantly decreased K(m) and increased V(max) of zidovudine O-glucuronidation by UGT2B7. Zidovudine 80-90 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 20-24 21098645-2 2011 Glucuronidation of 13 UGT substrates, 1-naphthol, diclofenac, epitestosterone, estradiol, ethinylestradiol, indomethacin, oxazepam, R- and S-propranolol, propofol, testosterone, trifluoperazine, and zidovudine, were studied to derive a broad view on the effect of cell differentiation on the glucuronidation activities of different human UGTs. Zidovudine 199-209 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 22-25 18832476-5 2009 In the presence of combined P450 and UGT cofactors, CL(int) ranged from 2.8 to 688 microl/min/mg for zidovudine and buprenorphine, respectively; the clearance was approximately equal to the sum of the CL(int) values obtained in the presence of individual cofactors. Zidovudine 101-111 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 37-40 16542204-1 2006 AIMS: Using the fluconazole-zidovudine (AZT) interaction as a model, to determine whether inhibition of UDP-glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could be predicted quantitatively from in vitro kinetic data generated in the presence and absence bovine serum albumin (BSA). Zidovudine 40-43 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 104-131 16139098-5 2005 Co-incubation with bilirubin or 3"-azido-3"-deoxythymidine (UGT1A1 and 2B7 inhibitors, respectively) inhibited the greatest amount of ethyl glucuronide formation, though other UGT inhibitors also showed some effect. Zidovudine 32-58 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 60-63 15258106-1 2004 These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3"-azido-3"-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Zidovudine 147-173 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 69-112 15258106-1 2004 These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3"-azido-3"-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Zidovudine 147-173 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 114-117 15258106-1 2004 These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3"-azido-3"-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Zidovudine 175-178 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 69-112 15258106-1 2004 These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3"-azido-3"-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Zidovudine 175-178 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 114-117 15258106-1 2004 These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3"-azido-3"-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Zidovudine 175-178 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 220-223