PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18295533-3 2008 It has been previously shown that AZT is incorporated into DNA, where it causes mutations in the HPRT and TK genes. Zidovudine 34-37 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 97-101 1544855-0 1992 Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326. Zidovudine 19-22 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 50-55 1544855-1 1992 The anti-AIDS agent, AZT (3"-azido-3"-deoxythymidine), is mutagenic in a cultured human hepatoma cell line designated HepG2 at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) locus. Zidovudine 21-24 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 131-136 1544855-1 1992 The anti-AIDS agent, AZT (3"-azido-3"-deoxythymidine), is mutagenic in a cultured human hepatoma cell line designated HepG2 at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) locus. Zidovudine 21-24 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 138-185 1544855-1 1992 The anti-AIDS agent, AZT (3"-azido-3"-deoxythymidine), is mutagenic in a cultured human hepatoma cell line designated HepG2 at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) locus. Zidovudine 26-52 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 131-136 1544855-1 1992 The anti-AIDS agent, AZT (3"-azido-3"-deoxythymidine), is mutagenic in a cultured human hepatoma cell line designated HepG2 at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) locus. Zidovudine 26-52 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 138-185 12112380-0 2002 Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3"-azido-3"-deoxythymidine and 2",3"-dideoxyinosinedagger. Zidovudine 117-143 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 39-43 17358033-2 2007 In TK6 cells, dose-related increases in HPRT and TK mutant frequencies were found following 3 days of exposure to AZT or 3TC alone (33, 100, or 300 microM), or to equimolar amounts of AZT-3TC. Zidovudine 114-117 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 40-44 17358033-3 2007 Compared with single drug exposures, AZT-3TC coexposures generally yielded enhanced elevations in HPRT and TK mutant frequencies. Zidovudine 37-40 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 98-102 12112380-4 2002 The purpose of the current study was to characterize the mutational specificity of equimolar mixtures of 100 microM or 300 microM AZT + ddI at the HPRT and TK loci of exposed cells vs. unexposed control cells, and to compare the resulting mutational spectra data to those previously found in cells exposed to AZT alone (Sussman H et al. Zidovudine 130-133 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 147-151 12112380-13 2002 In addition, cotreatments of ddI with AZT led to substantial absolute increases in the mutant fraction of other classes of mutations, unlike cells exposed solely to AZT [e.g., the frequency of point mutations among HPRT mutants was significantly increased by 130 and 323% over the background value (4.25 x 10(-6)) in cells exposed to 100 and 300 microM AZT-ddI, respectively]. Zidovudine 38-41 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 215-219 10970446-1 2000 Previous experiments in our research group showed that 3"-azido-3"-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the autosomal thymidine kinase (TK) genes in human lymphoblastoid cells and that there was a significant positive correlation between AZT incorporation into cellular DNA and AZT-induced TK Mfs. Zidovudine 55-81 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 194-198 10970446-1 2000 Previous experiments in our research group showed that 3"-azido-3"-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the autosomal thymidine kinase (TK) genes in human lymphoblastoid cells and that there was a significant positive correlation between AZT incorporation into cellular DNA and AZT-induced TK Mfs. Zidovudine 83-86 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 194-198 10970446-8 2000 These results, which are consistent with findings on the mutagenicity of AZT at the HPRT and TK genes, indicate the need for further investigations on the potential long-term side effects of AZT on humans, especially those who receive AZT for a prophylactic reason. Zidovudine 73-76 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 84-88 10526209-0 1999 Genotoxicity of 3"-azido-3"-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT. Zidovudine 16-42 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 184-188 10526209-2 1999 The purpose of the present study was to investigate the relationships between incorporation of AZT into DNA, and the frequency and spectrum of mutations at the HPRT locus of the human lymphoblastoid cell line, TK6, following in vitro exposures to AZT. Zidovudine 95-98 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 160-164 10526209-6 1999 After 3 days of AZT exposure, HPRT mutant frequency was significantly increased (1.8-fold, p = 0.016) compared to background (mutant frequency = 3.78 x 10(-6)). Zidovudine 16-19 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 30-34