PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21276846-8 2011 From these results, it was found that the gelatinolytic activity was regulated (1) by enzymatic inhibition of both MMP-9 and MMP-2, as well as (2) by the decreased production of MMP-9 via ERK pathways in EFA treated HASMCs. hasmcs 216-222 mitogen-activated protein kinase 1 Homo sapiens 188-191 20697944-1 2010 OBJECTIVE: To investigate the relationship between the proliferation of sensitized human airway smooth muscle cells (HASMCs) and the expression of extracellular signal regulated kinase (ERK) and the effect of Shenmai Injection (SMI) on HASMCs. hasmcs 117-123 mitogen-activated protein kinase 1 Homo sapiens 147-184 20697944-1 2010 OBJECTIVE: To investigate the relationship between the proliferation of sensitized human airway smooth muscle cells (HASMCs) and the expression of extracellular signal regulated kinase (ERK) and the effect of Shenmai Injection (SMI) on HASMCs. hasmcs 117-123 mitogen-activated protein kinase 1 Homo sapiens 186-189 20697944-11 2010 The expression of ERK can be inhibited by SMI in a dose-dependent manner, thus preventing the proliferation of HASMCs. hasmcs 111-117 mitogen-activated protein kinase 1 Homo sapiens 18-21 15695555-11 2005 We conclude that d-glucose upregulates the protein and message expression and functional activity of ENT-1 in HASMCs, possibly via MAPK/ERK-dependent pathways. hasmcs 110-116 mitogen-activated protein kinase 1 Homo sapiens 136-139 20979800-5 2010 Then, HASMCs were transfected with ERK sense, antisense and mismatched oligodeoxynucleotides (ODN). hasmcs 6-12 mitogen-activated protein kinase 1 Homo sapiens 35-38 20979800-12 2010 The expression of ERK mRNA (0.43 +- 0.06) and the activation ratio of ERK (63 +- 6)% in HASMCs from group AODNs were significantly decreased compared to those of chronic asthma group, which were (0.89 +- 0.09), (87 +- 8)%, respectively (F = 78.043, 87.288, respectively, P < 0.05). hasmcs 88-94 mitogen-activated protein kinase 1 Homo sapiens 18-21 20979800-12 2010 The expression of ERK mRNA (0.43 +- 0.06) and the activation ratio of ERK (63 +- 6)% in HASMCs from group AODNs were significantly decreased compared to those of chronic asthma group, which were (0.89 +- 0.09), (87 +- 8)%, respectively (F = 78.043, 87.288, respectively, P < 0.05). hasmcs 88-94 mitogen-activated protein kinase 1 Homo sapiens 70-73 20979800-13 2010 ERK antisense ODN inhibited the proliferation of HASMCs and induced the apoptosis of HASMCs, but the sense and the mismatched ones did not have these effects. hasmcs 49-55 mitogen-activated protein kinase 1 Homo sapiens 0-3 20979800-13 2010 ERK antisense ODN inhibited the proliferation of HASMCs and induced the apoptosis of HASMCs, but the sense and the mismatched ones did not have these effects. hasmcs 85-91 mitogen-activated protein kinase 1 Homo sapiens 0-3 20979800-14 2010 CONCLUSIONS: ERK antisense ODN inhibited the proliferation and increased the apoptosis in cultured HASMCs passively sensitized with 10% serum from asthmatic patients. hasmcs 99-105 mitogen-activated protein kinase 1 Homo sapiens 13-16 20979800-15 2010 The result suggests that ERK signaling pathway may contribute to the proliferation and apoptosis of HASMCs in asthmatic patients. hasmcs 100-106 mitogen-activated protein kinase 1 Homo sapiens 25-28 18679784-6 2008 Pulsatile atmospheric pressure increased the amount of phosphorylated extracellular signal-regulated kinase (ERK) by approximately 54% in HASMCs. hasmcs 138-144 mitogen-activated protein kinase 1 Homo sapiens 70-107 18679784-6 2008 Pulsatile atmospheric pressure increased the amount of phosphorylated extracellular signal-regulated kinase (ERK) by approximately 54% in HASMCs. hasmcs 138-144 mitogen-activated protein kinase 1 Homo sapiens 109-112 26502995-5 2015 Furthermore, the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway was evaluated in HASMCs. hasmcs 122-128 mitogen-activated protein kinase 1 Homo sapiens 35-80 15545519-9 2004 U0126, a specific inhibitor of ERK phosphorylation, significantly inhibited ERK 1/2 phosphorylation and reduced resistin-simulated proliferation of HASMCs. hasmcs 148-154 mitogen-activated protein kinase 1 Homo sapiens 31-34 12534349-6 2003 In hASMCs, we showed that ERK activation depended on both pertussis-sensitive and -insensitive G alpha-proteins. hasmcs 3-9 mitogen-activated protein kinase 1 Homo sapiens 26-29 15371330-6 2004 Suppression of extracellular signal-regulated kinase (ERK) activity, but not of p38 activity, inhibited the H2S-induced apoptosis of HASMCs. hasmcs 133-139 mitogen-activated protein kinase 1 Homo sapiens 15-52 15371330-6 2004 Suppression of extracellular signal-regulated kinase (ERK) activity, but not of p38 activity, inhibited the H2S-induced apoptosis of HASMCs. hasmcs 133-139 mitogen-activated protein kinase 1 Homo sapiens 54-57 15371330-7 2004 The activation of ERK by H2S in HASMCs was accompanied by increased caspase-3 activity. hasmcs 32-38 mitogen-activated protein kinase 1 Homo sapiens 18-21 15371330-11 2004 Of the three investigated MAPKs, only ERK played an active role in mediating H2S-induced apoptosis of HASMCs by activating caspase-3. hasmcs 102-108 mitogen-activated protein kinase 1 Homo sapiens 38-41 26502995-5 2015 Furthermore, the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway was evaluated in HASMCs. hasmcs 122-128 mitogen-activated protein kinase 1 Homo sapiens 82-85 24880525-10 2014 These results suggest that EGCG inhibits the proliferation of HASMCs in vitro largely via Mfn-2-mediated suppression of the Ras-Raf-ERK/MAPK signaling pathway. hasmcs 62-68 mitogen-activated protein kinase 1 Homo sapiens 132-135