PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2948652-0 1986 Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. 5-Hydroxytryptophan 11-17 proopiomelanocortin Homo sapiens 55-69 2559587-7 1989 The amplitudes of the cortisol, ACTH and PRL responses to L-5-HTP were significantly and positively correlated. 5-Hydroxytryptophan 58-65 proopiomelanocortin Homo sapiens 32-36 2948652-4 1986 In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 58-80 proopiomelanocortin Homo sapiens 129-143 2948652-4 1986 In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 58-80 proopiomelanocortin Homo sapiens 145-152 2948652-4 1986 In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 82-88 proopiomelanocortin Homo sapiens 129-143 2948652-4 1986 In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 82-88 proopiomelanocortin Homo sapiens 145-152 2948652-6 1986 L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05). 5-Hydroxytryptophan 0-6 proopiomelanocortin Homo sapiens 69-76 2948652-7 1986 L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone. 5-Hydroxytryptophan 0-6 proopiomelanocortin Homo sapiens 45-52 2948652-7 1986 L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone. 5-Hydroxytryptophan 109-115 proopiomelanocortin Homo sapiens 45-52 2945645-0 1986 Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception: possible implications in migraine prophylaxis. 5-Hydroxytryptophan 11-17 proopiomelanocortin Homo sapiens 55-69 2945645-3 1986 In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 58-79 proopiomelanocortin Homo sapiens 128-142 2945645-3 1986 In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 58-79 proopiomelanocortin Homo sapiens 144-151 2945645-3 1986 In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 81-87 proopiomelanocortin Homo sapiens 128-142 2945645-3 1986 In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. 5-Hydroxytryptophan 81-87 proopiomelanocortin Homo sapiens 144-151 2945645-5 1986 L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05). 5-Hydroxytryptophan 0-6 proopiomelanocortin Homo sapiens 69-76 2945645-6 1986 L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) greater than that induced by L-5HTP alone. 5-Hydroxytryptophan 0-6 proopiomelanocortin Homo sapiens 45-52 2945645-6 1986 L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) greater than that induced by L-5HTP alone. 5-Hydroxytryptophan 115-121 proopiomelanocortin Homo sapiens 45-52 185101-13 1976 Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH. 5-Hydroxytryptophan 83-103 proopiomelanocortin Homo sapiens 119-123 185101-13 1976 Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH. 5-Hydroxytryptophan 83-103 proopiomelanocortin Homo sapiens 285-289 4344307-0 1973 Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man. 5-Hydroxytryptophan 10-29 proopiomelanocortin Homo sapiens 60-64 4344307-0 1973 Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man. 5-Hydroxytryptophan 31-36 proopiomelanocortin Homo sapiens 60-64 17100126-7 2006 For the detection of ectopic ACTH-secreting tumours new imaging techniques, such as somatostatin receptor scintigraphy and positron emission tomography with 5-hydroxytryptophan, have become available. 5-Hydroxytryptophan 157-176 proopiomelanocortin Homo sapiens 29-33 20138102-7 2010 5-HTP-induced significant ACTH release reaching an E(max) of 60.2ng/L at 80min followed by cortisol with an E(max) of 246.4ng/mL at 110min. 5-Hydroxytryptophan 0-5 proopiomelanocortin Homo sapiens 26-30 8778905-1 1996 Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression. 5-Hydroxytryptophan 65-87 proopiomelanocortin Homo sapiens 133-160 8742680-4 1996 After L-5-hydroxytryptophan treatment, serum serotonin and both plasma and mononuclear cell beta-endorphin levels tended to be higher, though not significantly so, than prior to treatment, and the clinical score (frequency x intensity of headache attacks) was significantly lower in both headache groups than at the baseline. 5-Hydroxytryptophan 6-27 proopiomelanocortin Homo sapiens 92-106 8637392-2 1996 A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations. 5-Hydroxytryptophan 55-59 proopiomelanocortin Homo sapiens 193-197 8887988-0 1996 Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression. 5-Hydroxytryptophan 23-44 proopiomelanocortin Homo sapiens 66-80 8887988-1 1996 Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. 5-Hydroxytryptophan 63-84 proopiomelanocortin Homo sapiens 136-163 8887988-1 1996 Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. 5-Hydroxytryptophan 63-84 proopiomelanocortin Homo sapiens 165-169 8887988-1 1996 Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. 5-Hydroxytryptophan 86-93 proopiomelanocortin Homo sapiens 136-163 8887988-1 1996 Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. 5-Hydroxytryptophan 86-93 proopiomelanocortin Homo sapiens 165-169 8887988-3 1996 It was found that in major, but not minor, depressed subjects, L-5-HTP significantly increased post-DST beta-endorphin concentrations as compared to placebo. 5-Hydroxytryptophan 63-70 proopiomelanocortin Homo sapiens 104-118 8887988-4 1996 The L-5-HTP-induced post-DST beta-endorphin responses were significantly higher in major than in minor depressed subjects. 5-Hydroxytryptophan 4-11 proopiomelanocortin Homo sapiens 29-43 8887988-5 1996 There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses. 5-Hydroxytryptophan 58-65 proopiomelanocortin Homo sapiens 83-97 8887988-5 1996 There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses. 5-Hydroxytryptophan 58-65 proopiomelanocortin Homo sapiens 102-106 8887988-6 1996 There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin values and the Hamilton Depression Rating Scale (HDRS) score. 5-Hydroxytryptophan 58-65 proopiomelanocortin Homo sapiens 83-97 8887988-7 1996 The results show that the acute administration of L-5-HTP may increase the escape of beta-endorphin secretion from suppression by dexamethasone in major, but not minor, depression. 5-Hydroxytryptophan 50-57 proopiomelanocortin Homo sapiens 85-99 8778905-1 1996 Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression. 5-Hydroxytryptophan 65-87 proopiomelanocortin Homo sapiens 162-166 8778905-1 1996 Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression. 5-Hydroxytryptophan 89-96 proopiomelanocortin Homo sapiens 133-160 8778905-1 1996 Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression. 5-Hydroxytryptophan 89-96 proopiomelanocortin Homo sapiens 162-166 1851310-3 1991 A borderline effect of 5-HTP on plasma ACTH levels was found. 5-Hydroxytryptophan 23-28 proopiomelanocortin Homo sapiens 39-43 7899535-2 1995 L-5-HTP significantly enhanced post-DST ACTH and cortisol secretion in major--but not in minor--depressed subjects. 5-Hydroxytryptophan 0-7 proopiomelanocortin Homo sapiens 40-44 7899535-4 1995 L-5-HTP administration converted some major depressed ACTH or cortisol suppressors into nonsuppressors. 5-Hydroxytryptophan 0-7 proopiomelanocortin Homo sapiens 54-58 7899535-5 1995 L-5-HTP stimulated ACTH or cortisol secretion to the same extent in major depressed HPA-axis suppressors and nonsuppressors. 5-Hydroxytryptophan 0-7 proopiomelanocortin Homo sapiens 19-23 7899535-6 1995 It is concluded that L-5-HTP loading may augment ACTH and, consequently, cortisol escape from suppression by dexamethasone in major but not in minor depressed subjects. 5-Hydroxytryptophan 21-28 proopiomelanocortin Homo sapiens 49-53 1851310-0 1991 Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans. 5-Hydroxytryptophan 39-58 proopiomelanocortin Homo sapiens 78-82 2139731-8 1990 In both patients and controls, the 5HTP infusion led to substantial increases in plasma cortisol and beta-endorphin levels, while the plasma MHPG level was unchanged. 5-Hydroxytryptophan 35-39 proopiomelanocortin Homo sapiens 101-115 2143059-6 1990 In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine. 5-Hydroxytryptophan 200-219 proopiomelanocortin Homo sapiens 135-149