PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7697371-4 1994 The present result suggests that AADC decarboxylating L-5-hydroxytryptophan to serotonin in physiological conditions is also able to catalyze the in vivo decarboxylation of exogenous L-DOPA. 5-Hydroxytryptophan 54-75 dopa decarboxylase Rattus norvegicus 33-37 24068759-5 2014 In contrast, when we applied exogenous 5-HTP (in vitro or in vivo), AADC-containing vessels and neurons synthesized 5-HT, which contributed to increased motoneuron activity and muscle spasms (long-lasting reflexes, LLRs), by acting on 5-HT2 receptors (SB206553 sensitive) located on motoneurons (TTX resistant). 5-Hydroxytryptophan 39-44 dopa decarboxylase Rattus norvegicus 68-72 10773222-4 2000 Both benserazide and L-5-hydroxytryptophan (L-5-HTP) were found to produce concentration dependent decreases in AADC activity with K(i) values in the microM range. 5-Hydroxytryptophan 21-42 dopa decarboxylase Rattus norvegicus 112-116 10773222-4 2000 Both benserazide and L-5-hydroxytryptophan (L-5-HTP) were found to produce concentration dependent decreases in AADC activity with K(i) values in the microM range. 5-Hydroxytryptophan 44-51 dopa decarboxylase Rattus norvegicus 112-116 7712159-6 1995 The present findings suggest that (i) AADC in dopaminergic neurons of the SNC and in noradrenergic neurons of the LC can catalyze the in vivo decarboxylation of exogenous L-5HTP to produce 5HT, and (ii) most of the newly produced 5HT in the LC neurons is rapidly degraded by endogenous MAO. 5-Hydroxytryptophan 171-177 dopa decarboxylase Rattus norvegicus 38-42 26830512-2 2016 We have previously found that AADC cells in the spinal cord could increase their ability to produce serotonin (5-hydroxytryptamine) from 5-hydroxytryptophan after spinal cord injury (SCI). 5-Hydroxytryptophan 137-156 dopa decarboxylase Rattus norvegicus 30-34 26830512-3 2016 Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased. 5-Hydroxytryptophan 43-62 dopa decarboxylase Rattus norvegicus 8-12 26830512-3 2016 Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased. 5-Hydroxytryptophan 43-62 dopa decarboxylase Rattus norvegicus 172-176 26504602-2 2015 We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection. 5-Hydroxytryptophan 154-173 dopa decarboxylase Rattus norvegicus 78-104 26504602-2 2015 We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection. 5-Hydroxytryptophan 154-173 dopa decarboxylase Rattus norvegicus 106-110 26504602-2 2015 We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection. 5-Hydroxytryptophan 175-180 dopa decarboxylase Rattus norvegicus 78-104 26504602-2 2015 We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection. 5-Hydroxytryptophan 175-180 dopa decarboxylase Rattus norvegicus 106-110 25186745-5 2014 We show that, following complete transection of the rat spinal cord at S2 level, AADC cells distal to the lesion acquire the ability to produce 5-HT from its immediate precursor, 5-hydroxytryptophan. 5-Hydroxytryptophan 179-198 dopa decarboxylase Rattus norvegicus 81-85 24084697-1 2014 The PET tracer [(11)C]5-hydroxytryptophan ([(11)C]5-HTP), which is converted to [(11)C]5-hydroxytryptamine ([(11)C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to measure 5-HT synthesis rates. 5-Hydroxytryptophan 22-41 dopa decarboxylase Rattus norvegicus 159-163 9555017-5 1998 In response to NSD-1015 (an inhibitor of aromatic L-amino acid decarboxylase, AADC), 5-hydroxytryptophan (5-HTP) levels were substantially elevated in the SN grafted striata as compared with those in the sham grafted controls, which continued even after subsequent administration of L-3,4-dihydroxyphenylalanine (L-DOPA, 100 mg/kg i.p.). 5-Hydroxytryptophan 85-104 dopa decarboxylase Rattus norvegicus 78-82 8206708-13 1994 The localization of AADC-immunoreactivity in the photoreceptor cell inner segments is possibly related to the biosynthetic pathway of melatonin from 5-hydroxytryptophan. 5-Hydroxytryptophan 149-168 dopa decarboxylase Rattus norvegicus 20-24 8510830-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. 5-Hydroxytryptophan 69-88 dopa decarboxylase Rattus norvegicus 0-35 8510830-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. 5-Hydroxytryptophan 69-88 dopa decarboxylase Rattus norvegicus 37-41 1797228-1 1991 Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters. 5-Hydroxytryptophan 122-143 dopa decarboxylase Rattus norvegicus 0-35 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. 5-Hydroxytryptophan 135-154 dopa decarboxylase Rattus norvegicus 0-35 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. 5-Hydroxytryptophan 135-154 dopa decarboxylase Rattus norvegicus 37-41 1797228-1 1991 Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters. 5-Hydroxytryptophan 122-143 dopa decarboxylase Rattus norvegicus 37-41 3141816-1 1988 The accumulation rates of 3,4"-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) after inhibition of aromatic amino acid decarboxylase (AADC) by 3-hydroxybenzylhydrazine (NSD 1015) or 1-(DL-seryl)-2- (2,3,4-trihydroxybenzyl)hydrazine (Ro 4-4602) have widely been used as measurements of the in vivo synthesis rates of monoamines. 5-Hydroxytryptophan 86-91 dopa decarboxylase Rattus norvegicus 148-152 3151164-11 1988 Although dopa and 5-hydroxytryptophan are substrates for the same enzyme, aromatic L-amino-acid decarboxylase, simultaneous infusions of both amino acids at comparable rates gave no evidence of competitive inhibition of amine synthesis. 5-Hydroxytryptophan 18-37 dopa decarboxylase Rattus norvegicus 74-109 2081822-1 1990 By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT). 5-Hydroxytryptophan 313-332 dopa decarboxylase Rattus norvegicus 188-214 2081822-1 1990 By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT). 5-Hydroxytryptophan 313-332 dopa decarboxylase Rattus norvegicus 216-220 6333583-4 1984 After this treatment AADC activities could be detected in the monkey serum by using both L-DOPA and L-5-HTP as substrates. 5-Hydroxytryptophan 100-107 dopa decarboxylase Rattus norvegicus 21-25 6333583-6 1984 Serum AADC was partially purified from monkey and compared with that of rat using both L-DOPA and L-5-HTP as substrates, but the ratio of the activities for the two substrates did not change significantly in each fraction during purification from either monkey or rat serum. 5-Hydroxytryptophan 98-105 dopa decarboxylase Rattus norvegicus 6-10 6205316-3 1984 It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP. 5-Hydroxytryptophan 144-165 dopa decarboxylase Rattus norvegicus 54-89 6205316-3 1984 It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP. 5-Hydroxytryptophan 167-172 dopa decarboxylase Rattus norvegicus 54-89 6983619-1 1982 This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates. 5-Hydroxytryptophan 222-243 dopa decarboxylase Rattus norvegicus 78-82 6983619-0 1982 Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats. 5-Hydroxytryptophan 105-126 dopa decarboxylase Rattus norvegicus 53-79 6983619-1 1982 This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates. 5-Hydroxytryptophan 245-252 dopa decarboxylase Rattus norvegicus 78-82 6983619-4 1982 AADC activities towards L-DOPA and L-5-HTP as substrates were also decreased significantly in almost all tissues of SC-treated rats. 5-Hydroxytryptophan 35-42 dopa decarboxylase Rattus norvegicus 0-4 6983619-7 1982 Serum AADC activities were decreased drastically using both L-DOPA and L-5-HTP as substrates. 5-Hydroxytryptophan 71-78 dopa decarboxylase Rattus norvegicus 6-10 37141-1 1979 Rat gastric oxyntic glands contain argyrophil "enterochromaffin-like" endocrine cells that synthesize and store histamine and also have APUD ability--they can take up exogenous L-5-hydroxytryptophan (5-HTP), can decarboxylate it to 5-hydroxytryptamine (5-HT, serotonin) by the enzyme DOPA-decarboxylase, and can store the amine. 5-Hydroxytryptophan 177-198 dopa decarboxylase Rattus norvegicus 284-302 6113187-1 1981 The rat stomach was shown some years ago to contain numerous endocrine cells with APUD ability--cells that could take up the amino acids L-5-hydroxytryptophan (5-HTP) or L-dihydroxyphenylalanine (L-DOPA) and could decarboxylate them to their respective amines, 5-hydroxytryptamine (5-HT, serotonin) and dopamine, by means of the enzyme DOPA-decarboxylase. 5-Hydroxytryptophan 137-158 dopa decarboxylase Rattus norvegicus 336-354 6113187-1 1981 The rat stomach was shown some years ago to contain numerous endocrine cells with APUD ability--cells that could take up the amino acids L-5-hydroxytryptophan (5-HTP) or L-dihydroxyphenylalanine (L-DOPA) and could decarboxylate them to their respective amines, 5-hydroxytryptamine (5-HT, serotonin) and dopamine, by means of the enzyme DOPA-decarboxylase. 5-Hydroxytryptophan 160-165 dopa decarboxylase Rattus norvegicus 336-354