PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35293300-10	2022	Time-dependant CYP inhibition potential of ZY12201 was assessed against CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 and no apparent IC50 shift was observed.	zy12201	43-50	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-86	
35293300-13	2022	Inhibition of CYP1A2, CYP2B6, CYP2C19, and CYP2E1 by ZY12201 was competitive, while inhibition of CYP2C8, CYP2C9, CYP2D6, and CYP3A4/5 was of mixed-mode.	zy12201	53-60	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	22-28	
35293300-14	2022	ZY12201 is a non-time-dependent inhibitor of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5.	zy12201	0-7	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	53-59	
35293300-9	2022	ZY12201 Ki values were 0.38, 0.25, 0.07, 0.01, 0.06, 0.02, 7.13, 0.03 and 0.003 muM for CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5 (substrate: testosterone) and CYP3A4/5 (substrate: midazolam), respectively.	zy12201	0-7	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	96-102