PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7401119-2	1980	Crystals of nafoxidine hydrochloride-ethanol are monoclinic with cell dimensions a = 17.040, b = 7.967, c = 25.260 A, beta = 123.7 degrees, and space group P21/c with four formula units per cell.	Ethanol	37-44	H3 histone pseudogene 16	Homo sapiens	156-159	
31671572-7	2019	These results indicate that ethanol-induced dysregulation of NRF2 coordinately regulates PCNA/CYCLIN-D1/p21 involving growth network, at least partially to set a stage for placental perturbations.	Ethanol	28-35	H3 histone pseudogene 16	Homo sapiens	104-107	
31706015-8	2019	Anatomical studies show that the expression of Ki-67 was greater and ratio of p21-positive cells to the ratio of Ki-67-expressing cells was lower in animals in which the ethanol exposure included gastrulation.	Ethanol	170-177	H3 histone pseudogene 16	Homo sapiens	78-81	
25337571-9	2014	Ethanol also increased the phosphorylation of p53 and p53 activation was followed by an increase in the p21 tumor suppressor protein accompanied by a gradual decrease in phospho-Rb protein.	Ethanol	0-7	H3 histone pseudogene 16	Homo sapiens	104-107	
29895782-2	2018	EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype (SASP) genes (interleukin [IL]-1beta, IL-6, IL-8 and tumor necrosis factor-alpha) in HPDLCs and cementoblasts.	Ethanol	0-4	H3 histone pseudogene 16	Homo sapiens	126-129	
29318697-8	2018	We found that oroxylin A inhibited ethanol-induced hepatocyte senescence by decreasing the number of SA-beta-gal-positive LO2 cells and reducing the expression of senescence markers p16, p21 and Hmga1 in vitro.	Ethanol	35-42	H3 histone pseudogene 16	Homo sapiens	187-190	
25206494-7	2013	Ethanol also increased p53 phosphorylation, followed by an increase in p21 tumor suppressor protein and a decrease in phospho-Rb (retinoblastoma) protein, leading to alterations in the expressions and activity of cyclin dependent protein kinases.	Ethanol	0-7	H3 histone pseudogene 16	Homo sapiens	71-74	
22545405-5	2012	The structure of dimerized griseofulvin, C34H32C12O12 x C2H6O x H2O, at 100 K has monoclinic (P2(1)) symmetry.	Ethanol	56-61	H3 histone pseudogene 16	Homo sapiens	94-99	
11329487-0	2001	Ethanol decreases expression of p21 and increases hyperphosphorylated pRb in cell lines of squamous cell carcinomas of the head and neck.	Ethanol	0-7	H3 histone pseudogene 16	Homo sapiens	32-35	
9358730-2	1997	Two depsipeptides and one ethanol molecule per asymmetric unit crystallize in space group P2(1) (Z = 4); a = 14.579, b = 39.795, c = 13.928 A, beta = 116.90, Rl = 0.0757.	Ethanol	26-33	H3 histone pseudogene 16	Homo sapiens	90-95	
24026251-12	2013	The present study also showed that treatment with ethanol resulted in significant increases in the expression of p21, but not the levels of p53 and p53 target genes such as Bax, Puma, and Bcl-2.	Ethanol	50-57	H3 histone pseudogene 16	Homo sapiens	113-116	
24026251-13	2013	Furthermore, the inhibition of p75NTR expression or Sp1 activity suppressed ethanol-induced p21 expression, cell cycle arrest, and apoptosis.	Ethanol	76-83	H3 histone pseudogene 16	Homo sapiens	92-95	
22986577-10	2013	Furthermore, ethanol in combination with TRAIL increased the expression of cyclin-dependent kinase inhibitor p21 and decreased the levels of Bcl-2 and phosphorylated-AKT.	Ethanol	13-20	H3 histone pseudogene 16	Homo sapiens	109-112	
22802695-4	2012	Western blotting on the expression of cell cycle inhibitors showed that p21 and p27 was up-regulated as ethanol concentration increases from 0 to 1.5% whilst the cell cycle regulators, cdk1, cdk2, and cdk4 as well as Cyclin A, Cyclin B1 and Cyclin E1, were gradually down-regulated.	Ethanol	104-111	H3 histone pseudogene 16	Homo sapiens	72-75	
20623640-4	2010	Lower protein expression levels of p16, p21/Cip1, and p27/Kip1 were detected in the ethanol-treated E40 cells.	Ethanol	84-91	H3 histone pseudogene 16	Homo sapiens	40-43	
19627195-7	2009	However, cotreatment with dropwort or Sedum ethanol extract significantly lowered p53, p21, and p16 levels and intracellular reactive oxygen species levels and attenuated the cell cycle arrest compared with H(2)O(2)-alone treatment.	Ethanol	44-51	H3 histone pseudogene 16	Homo sapiens	87-90	
12711791-1	2003	The title compound is an ethanol-solvated salt, C(16)H(38)N(4)(2+) x -2C(11)H(7)O(2)(-) x -2C(2)H(6)O, in which the cation lies across a centre of inversion in P2(1)/c.	Ethanol	25-32	H3 histone pseudogene 16	Homo sapiens	160-165