PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31610228-8 2020 Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-gamma (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-beta1 (p = 0.017) compared with control patients. Ethanol 14-21 C-C motif chemokine ligand 2 Homo sapiens 103-108 31610228-12 2020 CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-gamma and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-beta1). Ethanol 26-33 C-C motif chemokine ligand 2 Homo sapiens 199-204 31705896-0 2020 CCL2/CCR2 Chemokine System in Embryonic Hypothalamus: Involvement in Sexually Dimorphic Stimulatory Effects of Prenatal Ethanol Exposure on Peptide-Expressing Neurons. Ethanol 120-127 C-C motif chemokine ligand 2 Homo sapiens 0-4 31705896-4 2020 We found that prenatal ethanol exposure increases the expression and density of CCL2 and CCR2 cells along with MCH neurons in the LH and the colocalization of CCL2 with MCH. Ethanol 23-30 C-C motif chemokine ligand 2 Homo sapiens 80-84 31705896-4 2020 We found that prenatal ethanol exposure increases the expression and density of CCL2 and CCR2 cells along with MCH neurons in the LH and the colocalization of CCL2 with MCH. Ethanol 23-30 C-C motif chemokine ligand 2 Homo sapiens 159-163 31705896-6 2020 These results, which in the embryo anatomically and functionally link the CCL2/CCR2 system to MCH neurons in the LH, suggest an important role for this neuroimmune system in mediating ethanol"s sexually dimorphic, stimulatory effect on MCH neurons that may promote higher level of alcohol consumption described in females. Ethanol 184-191 C-C motif chemokine ligand 2 Homo sapiens 74-78 31705896-6 2020 These results, which in the embryo anatomically and functionally link the CCL2/CCR2 system to MCH neurons in the LH, suggest an important role for this neuroimmune system in mediating ethanol"s sexually dimorphic, stimulatory effect on MCH neurons that may promote higher level of alcohol consumption described in females. Ethanol 281-288 C-C motif chemokine ligand 2 Homo sapiens 74-78 31211863-11 2019 An increased mRNA expression of IL-6, IL-8, and MCP-1 by FAEEs is key finding to suggest a metabolic basis of EtOH-induced inflammatory response. Ethanol 110-114 C-C motif chemokine ligand 2 Homo sapiens 48-53 25557254-0 2015 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRalpha. Ethanol 41-48 C-C motif chemokine ligand 2 Homo sapiens 115-120 30201767-0 2018 Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin-Concentrating Hormone and Behavior in Adolescent Offspring. Ethanol 88-95 C-C motif chemokine ligand 2 Homo sapiens 13-17 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 172-176 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 219-223 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 219-223 30201767-5 2018 We show that these neuronal and behavioral changes are similarly produced by maternal administration of CCL2 (4 or 8 mug/kg/d, E10-E15) and blocked by maternal administration of a CCR2 antagonist INCB3344 (1 mg/kg/d, E10-E15), and these effects of ethanol and CCL2 are sexually dimorphic, consistently stronger in females. Ethanol 248-255 C-C motif chemokine ligand 2 Homo sapiens 104-108 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Ethanol 136-143 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Ethanol 309-316 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 82-89 C-C motif chemokine ligand 2 Homo sapiens 71-75 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 130-137 C-C motif chemokine ligand 2 Homo sapiens 71-75 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 130-137 C-C motif chemokine ligand 2 Homo sapiens 71-75 26721307-6 2016 In general, EtOH decreased secretion of IP-10, IL-6, eotaxin, GCSF, and MCP-1. Ethanol 12-16 C-C motif chemokine ligand 2 Homo sapiens 72-77 29236160-4 2018 In this chapter, we will focus on key cytokines (e.g., IL-1, IL-6, TNF-alpha) and chemokines (e.g., MCP-1/CCL2) that mediate the ethanol-induced neuroimmune responses. Ethanol 129-136 C-C motif chemokine ligand 2 Homo sapiens 100-105 29236160-4 2018 In this chapter, we will focus on key cytokines (e.g., IL-1, IL-6, TNF-alpha) and chemokines (e.g., MCP-1/CCL2) that mediate the ethanol-induced neuroimmune responses. Ethanol 129-136 C-C motif chemokine ligand 2 Homo sapiens 106-110 26683974-0 2016 Chronic Intracerebroventricular Infusion of Monocyte Chemoattractant Protein-1 Leads to a Persistent Increase in Sweetened Ethanol Consumption During Operant Self-Administration But Does Not Influence Sucrose Consumption in Long-Evans Rats. Ethanol 123-130 C-C motif chemokine ligand 2 Homo sapiens 44-78 25557254-4 2015 Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC). Ethanol 124-131 C-C motif chemokine ligand 2 Homo sapiens 81-86 22205309-7 2012 Both ethanol and phenolic compounds of RW downregulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1. Ethanol 5-12 C-C motif chemokine ligand 2 Homo sapiens 114-144 26461414-9 2014 Very recently, it has been demonstrated that the inhibition of LXRalpha by 22-s-HC dramatically represses steatosis and HIF-1 mediated activation of MCP-1 in ethanol-induced fatty liver injury in hepatocytes as well as in Kupferr cells. Ethanol 158-165 C-C motif chemokine ligand 2 Homo sapiens 149-154 18190912-14 2008 These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis. Ethanol 122-129 C-C motif chemokine ligand 2 Homo sapiens 51-56 18840498-6 2008 Ethanol decreased LPS-stimulated IL-6, IL-8, TNF-alpha, and MCP-1 dose-dependently (all p<0.01). Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 60-65 15908470-5 2005 In addition, EtOH significantly reduced NF-kappaB and AP-1 binding activity induced by IL-1beta and inhibited MCP-1 gene transcription. Ethanol 13-17 C-C motif chemokine ligand 2 Homo sapiens 110-115 18398813-7 2008 Intake of ethanol or de-alcoholised red wine significantly reduced monocyte chemoattractant protein-1 (MCP-1)-induced monocyte migration by 58% (p<0.05; n=6) and 36% (p<0.05; n=7) and FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced migration by 41% (p<0.05) and 36% (p<0.05), respectively. Ethanol 10-17 C-C motif chemokine ligand 2 Homo sapiens 67-101 18398813-7 2008 Intake of ethanol or de-alcoholised red wine significantly reduced monocyte chemoattractant protein-1 (MCP-1)-induced monocyte migration by 58% (p<0.05; n=6) and 36% (p<0.05; n=7) and FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced migration by 41% (p<0.05) and 36% (p<0.05), respectively. Ethanol 10-17 C-C motif chemokine ligand 2 Homo sapiens 103-108 16970955-0 2007 Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 121-126 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Ethanol 25-32 C-C motif chemokine ligand 2 Homo sapiens 128-133 15908470-0 2005 Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 17-47 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 53-60 C-C motif chemokine ligand 2 Homo sapiens 83-113 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 53-60 C-C motif chemokine ligand 2 Homo sapiens 115-120 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 62-66 C-C motif chemokine ligand 2 Homo sapiens 83-113 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 62-66 C-C motif chemokine ligand 2 Homo sapiens 115-120 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 146-150 C-C motif chemokine ligand 2 Homo sapiens 37-42 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 146-150 C-C motif chemokine ligand 2 Homo sapiens 198-203 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 307-311 C-C motif chemokine ligand 2 Homo sapiens 37-42 15908470-3 2005 Similarly, EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 mRNA expression. Ethanol 11-15 C-C motif chemokine ligand 2 Homo sapiens 63-68 15908470-4 2005 Experiments with actinomycin D demonstrated that EtOH decreased the stability of MCP-1 mRNA. Ethanol 49-53 C-C motif chemokine ligand 2 Homo sapiens 81-86 15908470-7 2005 Modulation of the expression of MCP-1 represents a mechanism whereby EtOH could inhibit atherogenesis by blocking the crucial early step of monocyte adhesion and subsequent recruitment to the subendothelial space. Ethanol 69-73 C-C motif chemokine ligand 2 Homo sapiens 32-37 15589507-7 2005 Among studied inflammatory genes, induction of IL-1beta and MCP-1 was potentiated in animals injected with EtOH plus Tat. Ethanol 107-111 C-C motif chemokine ligand 2 Homo sapiens 60-65 15528377-7 2004 Ethanol, at concentrations within the range found in human blood after acute exposure and below the levels that induce cytotoxicity (0.1-0.5%), did not induce endothelial cell activation, but significantly inhibited TNF-mediated endothelial cell activation, as measured by adhesion molecule (E-selectin, ICAM-1, VCAM-1) expression and chemokine (IL-8, MCP-1, RANTES) production and leukocyte adhesion in vitro. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 352-357 11093800-9 2000 In SH-SY5Y cells, ethanol also decreased mRNA and secreted protein levels for monocyte chemotactic protein 1, an effect that could contribute to the protective role of moderate ethanol consumption in atherosclerotic vascular disease. Ethanol 18-25 C-C motif chemokine ligand 2 Homo sapiens 78-108 11388697-10 2001 Results show that in vivo ethanol was associated with downregulation of MIP-1alpha and MCP-1 mRNA expression and protein release in primary cultures of Kupffer cells. Ethanol 26-33 C-C motif chemokine ligand 2 Homo sapiens 87-92 11093800-9 2000 In SH-SY5Y cells, ethanol also decreased mRNA and secreted protein levels for monocyte chemotactic protein 1, an effect that could contribute to the protective role of moderate ethanol consumption in atherosclerotic vascular disease. Ethanol 177-184 C-C motif chemokine ligand 2 Homo sapiens 78-108 32713794-0 2020 Erratum to "CCL2/CCR2 Chemokine System in Embryonic Hypothalamus: Involvement in Sexually Dimorphic Stimulatory Effects of Prenatal Ethanol Exposure on Peptide-Expressing Neurons" [Neuroscience 424C (2020) 155-171]. Ethanol 132-139 C-C motif chemokine ligand 2 Homo sapiens 12-16