PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18490896-7 2008 In fact, MnSOD upregulation by exposure to ethanol in vitro was much more pronounced in p66KO versus wild-type isolated liver cells, and blunted in HepG2 cells overexpressing p66shc. Ethanol 43-50 superoxide dismutase 2 Homo sapiens 9-14 22246134-12 2012 Antioxidant enzymes, including GPx-1, PRX-1 and SOD-2, had an increased expression at 1% ethanol. Ethanol 89-96 superoxide dismutase 2 Homo sapiens 48-53 21352821-7 2011 All the agents, except catechin, tended to reduce the expression of SOD2 induced by ethanol. Ethanol 84-91 superoxide dismutase 2 Homo sapiens 68-72 7487113-7 1995 In order to investigate the mechanism of the cellular adaptive response to ethanol-induced oxidative stress, the effects of short-term ethanol exposure on MnSOD RNA, protein, and activity were determined in a human hepatoma cell line (HepG2). Ethanol 135-142 superoxide dismutase 2 Homo sapiens 155-160 15051327-4 2004 The consistent induction of the mitochondrial antioxidant enzyme manganese superoxide dismutase (Mn-SOD) observed in experimental animals after acute and chronic ethanol administration has all the characteristics of a "stress response" to an oxidative insult. Ethanol 162-169 superoxide dismutase 2 Homo sapiens 65-95 15051327-4 2004 The consistent induction of the mitochondrial antioxidant enzyme manganese superoxide dismutase (Mn-SOD) observed in experimental animals after acute and chronic ethanol administration has all the characteristics of a "stress response" to an oxidative insult. Ethanol 162-169 superoxide dismutase 2 Homo sapiens 97-103 9660302-12 1998 Both TNF and ethanol increased HepG2 cell MnSOD activity in short-term (72 hr) cultures with ethanol. Ethanol 13-20 superoxide dismutase 2 Homo sapiens 42-47 9660302-12 1998 Both TNF and ethanol increased HepG2 cell MnSOD activity in short-term (72 hr) cultures with ethanol. Ethanol 93-100 superoxide dismutase 2 Homo sapiens 42-47 7487113-8 1995 We found that exposure to ethanol (25 mM concentration) for 72 h increased the protein level and enzyme activity of MnSOD. Ethanol 26-33 superoxide dismutase 2 Homo sapiens 116-121 7487113-12 1995 Thus it appears that both TNF and ethanol are capable of increasing MnSOD activity presumably via enhanced oxidative stress. Ethanol 34-41 superoxide dismutase 2 Homo sapiens 68-73 7487113-13 1995 However, unlike TNF, acute ethanol administration increases the activity of MnSOD without increasing MnSOD mRNA. Ethanol 27-34 superoxide dismutase 2 Homo sapiens 76-81 7487113-14 1995 The increase in MnSOD after a short-term dose of ethanol is diminished with repeated ethanol administrations. Ethanol 49-56 superoxide dismutase 2 Homo sapiens 16-21 7487113-14 1995 The increase in MnSOD after a short-term dose of ethanol is diminished with repeated ethanol administrations. Ethanol 85-92 superoxide dismutase 2 Homo sapiens 16-21 7487113-16 1995 If this adaptive response of MnSOD is lessened, it may have implications in the increased toxicity due to prolonged ethanol exposure. Ethanol 116-123 superoxide dismutase 2 Homo sapiens 29-34 8024580-1 1994 On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supplemented solid diet for three weeks. Ethanol 41-48 superoxide dismutase 2 Homo sapiens 210-215 8024580-1 1994 On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supplemented solid diet for three weeks. Ethanol 257-264 superoxide dismutase 2 Homo sapiens 167-208 8024580-1 1994 On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supplemented solid diet for three weeks. Ethanol 257-264 superoxide dismutase 2 Homo sapiens 210-215 4039529-3 1985 The activity of MnSOD was higher in the ethanol-fed group while the activity of CuZnSOD tended to be lower. Ethanol 40-47 superoxide dismutase 2 Homo sapiens 16-21 4039529-4 1985 The finding of increased activity of MnSOD is consistent with the finding of enlarged mitochondria and increased liver Mn in the ethanol-fed group. Ethanol 129-136 superoxide dismutase 2 Homo sapiens 37-42 4039529-5 1985 Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. Ethanol 90-97 superoxide dismutase 2 Homo sapiens 10-15 4039529-7 1985 Thus, the chronic consumption of ethanol results in altered levels of trace minerals and SOD activities in the liver which in turn may contribute to hepatic injury. Ethanol 33-40 superoxide dismutase 2 Homo sapiens 89-92 6685298-1 1983 Manganese superoxide dismutase (Mn-SOD) studied during ethanol vapor inhalation shows no changes during the inhalation period (4 days) and a transient increase 12 hours after ethanol withdrawal. Ethanol 55-62 superoxide dismutase 2 Homo sapiens 0-30 6685298-1 1983 Manganese superoxide dismutase (Mn-SOD) studied during ethanol vapor inhalation shows no changes during the inhalation period (4 days) and a transient increase 12 hours after ethanol withdrawal. Ethanol 55-62 superoxide dismutase 2 Homo sapiens 32-38 6685298-1 1983 Manganese superoxide dismutase (Mn-SOD) studied during ethanol vapor inhalation shows no changes during the inhalation period (4 days) and a transient increase 12 hours after ethanol withdrawal. Ethanol 175-182 superoxide dismutase 2 Homo sapiens 0-30 6685298-1 1983 Manganese superoxide dismutase (Mn-SOD) studied during ethanol vapor inhalation shows no changes during the inhalation period (4 days) and a transient increase 12 hours after ethanol withdrawal. Ethanol 175-182 superoxide dismutase 2 Homo sapiens 32-38