PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9194048-13 1997 The electrophysiological and behavioral profiles of NPY and the Y1 agonist resembles those of anxiolytics such as ethanol and benzodiazepines. Ethanol 114-121 neuropeptide Y Homo sapiens 52-55 11095510-0 2000 Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus. Ethanol 6-13 neuropeptide Y Homo sapiens 24-27 11095510-4 2000 Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. Ethanol 84-91 neuropeptide Y Homo sapiens 0-14 11095510-4 2000 Neuropeptide Y (NPY) mRNA levels in ARC were significantly decreased in response to ethanol in the presence or absence of cyanamide compared to control. Ethanol 84-91 neuropeptide Y Homo sapiens 16-19 11095510-6 2000 These novel findings suggest that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. Ethanol 34-41 neuropeptide Y Homo sapiens 53-56 1431060-5 1992 In transverse vibratome sections, NPY nerve fibers, which ran perpendicular to the cut surfaces of the sections, were entirely stained after a 30-min wash in 50% ethanol. Ethanol 162-169 neuropeptide Y Homo sapiens 34-37 33045245-5 2020 Comparative analyses of the phenotype of transgenic and knockout NPY and Y receptor rodents unravels sex dependent differences in the functions of this neurotransmission system, potentially helping to develop therapeutics for a variety of sex-related disorders including metabolic syndrome, osteoporosis and ethanol addiction. Ethanol 308-315 neuropeptide Y Homo sapiens 65-68 2378751-2 1990 NPY content determined by radioimmunoassay was 3.13 +/- 0.79 pmol/g tissue (n = 6) in mucosa extracted with ethanol-acetic acid. Ethanol 108-115 neuropeptide Y Homo sapiens 0-3 29056151-2 2017 There is a long history of research implicating a role for NPY in modulating neurobiological responses to alcohol (ethanol) as well as other drugs of abuse. Ethanol 115-122 neuropeptide Y Homo sapiens 59-62 29056151-3 2017 Both ethanol exposure and withdrawal from chronic ethanol have been shown to produce changes in NPY and NPY receptor protein levels and mRNA expression in the CNS. Ethanol 5-12 neuropeptide Y Homo sapiens 96-99 29056151-3 2017 Both ethanol exposure and withdrawal from chronic ethanol have been shown to produce changes in NPY and NPY receptor protein levels and mRNA expression in the CNS. Ethanol 5-12 neuropeptide Y Homo sapiens 104-107 29056151-3 2017 Both ethanol exposure and withdrawal from chronic ethanol have been shown to produce changes in NPY and NPY receptor protein levels and mRNA expression in the CNS. Ethanol 50-57 neuropeptide Y Homo sapiens 96-99 29056151-3 2017 Both ethanol exposure and withdrawal from chronic ethanol have been shown to produce changes in NPY and NPY receptor protein levels and mRNA expression in the CNS. Ethanol 50-57 neuropeptide Y Homo sapiens 104-107 29056151-4 2017 Importantly, manipulations of NPY Y1 and Y2 receptor signaling have been shown to alter ethanol consumption and self-administration in a brain region-specific manner, with Y1 receptor activation and Y2 receptor blockade in regions of the extended amygdala promoting robust reductions of ethanol intake. Ethanol 88-95 neuropeptide Y Homo sapiens 30-33 29056151-4 2017 Importantly, manipulations of NPY Y1 and Y2 receptor signaling have been shown to alter ethanol consumption and self-administration in a brain region-specific manner, with Y1 receptor activation and Y2 receptor blockade in regions of the extended amygdala promoting robust reductions of ethanol intake. Ethanol 287-294 neuropeptide Y Homo sapiens 30-33 19120101-0 2008 Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake. Ethanol 70-77 neuropeptide Y Homo sapiens 8-22 23914176-7 2013 Neuropeptide Y, a powerful anti-stress neurotransmitter, has a profile of action on compulsive-like responding for ethanol similar to a CRF1 antagonist. Ethanol 115-122 neuropeptide Y Homo sapiens 0-14 23652361-2 2013 Previous research reported an inverse association between ethanol drinking and cerebral neuropeptide Y (NPY) levels. Ethanol 58-65 neuropeptide Y Homo sapiens 88-102 23652361-2 2013 Previous research reported an inverse association between ethanol drinking and cerebral neuropeptide Y (NPY) levels. Ethanol 58-65 neuropeptide Y Homo sapiens 104-107 22245775-8 2012 Finally, recent evidence shows that corticotropin-releasing factor (CRF), agouti-related protein (AgRP), neuropeptide Y (NPY), and ghrelin are also implicated as impacting this pattern of ethanol consumption. Ethanol 188-195 neuropeptide Y Homo sapiens 105-119 22245775-8 2012 Finally, recent evidence shows that corticotropin-releasing factor (CRF), agouti-related protein (AgRP), neuropeptide Y (NPY), and ghrelin are also implicated as impacting this pattern of ethanol consumption. Ethanol 188-195 neuropeptide Y Homo sapiens 121-124 25904345-6 2016 For example methamphetamine and nicotine lead to a consistent increase in NPY mRNA and protein levels in different brain sites whereas ethanol and opioids decrease NPY mRNA and protein expression. Ethanol 135-142 neuropeptide Y Homo sapiens 164-167 25904345-9 2016 NPY can produce pro-addictive effects (nicotine and heroin), but can also exert inhibitory effects on addictive behavior (AMPH, ethanol). Ethanol 128-135 neuropeptide Y Homo sapiens 0-3 24018426-8 2013 Furthermore, neuropeptide Y affects many processes depending on the central nervous system modifies ethanol consumption, affect circadian rhythms, memory processes, anxiety behavior. Ethanol 100-107 neuropeptide Y Homo sapiens 13-27 21995655-3 2011 NPY also has effects on feeding behavior, ethanol intake, sleep regulation, tissue growth and remodeling. Ethanol 42-49 neuropeptide Y Homo sapiens 0-3 15677721-2 2005 We have identified a Drosophila signaling system, comprising neurons expressing neuropeptide F (NPF, a homolog of mammalian neuropeptide Y) and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation. Ethanol 202-209 neuropeptide Y Homo sapiens 124-138 12626767-7 2003 More recently, using transgenic techniques and novel antagonists for the Y1, Y2, and Y5 receptors, NPY has been found to be a key player in the regulation of ethanol consumption and neuronal development. Ethanol 158-165 neuropeptide Y Homo sapiens 99-102 12454738-1 2002 Neuropeptide Y (NPY) modulates ethanol drinking in rodents. Ethanol 31-38 neuropeptide Y Homo sapiens 0-14 12454738-1 2002 Neuropeptide Y (NPY) modulates ethanol drinking in rodents. Ethanol 31-38 neuropeptide Y Homo sapiens 16-19 16989896-2 2006 NPY-Y(1)R signalling plays a prominent role in the regulation of several behavioural and physiological functions including feeding behaviour and energy balance, sexual hormone secretion, stress response, emotional behaviour, neuronal excitability and ethanol drinking. Ethanol 251-258 neuropeptide Y Homo sapiens 0-3 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-0 2004 A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. Ethanol 58-65 neuropeptide Y Homo sapiens 11-25 15337375-1 2004 In recent years, evidence has emerged suggesting that neuropeptide Y (NPY) is involved with neurobiological responses to ethanol and other drugs of abuse. Ethanol 121-128 neuropeptide Y Homo sapiens 54-68 15337375-1 2004 In recent years, evidence has emerged suggesting that neuropeptide Y (NPY) is involved with neurobiological responses to ethanol and other drugs of abuse. Ethanol 121-128 neuropeptide Y Homo sapiens 70-73 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 121-128 neuropeptide Y Homo sapiens 175-178 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 121-128 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 121-128 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 175-178 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 175-178 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 175-178 15337375-2 2004 Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Ethanol 141-148 neuropeptide Y Homo sapiens 195-198 15337375-3 2004 Evidence suggesting possible mechanism(s) by which NPY signaling modulates ethanol consumption are considered. Ethanol 75-82 neuropeptide Y Homo sapiens 51-54 15337375-4 2004 It is suggested that NPY may influence ethanol consumption by regulating basal levels of anxiety, by modulating the sedative effects of ethanol, and/or by modulating ethanol"s rewarding properties. Ethanol 39-46 neuropeptide Y Homo sapiens 21-24 15337375-4 2004 It is suggested that NPY may influence ethanol consumption by regulating basal levels of anxiety, by modulating the sedative effects of ethanol, and/or by modulating ethanol"s rewarding properties. Ethanol 136-143 neuropeptide Y Homo sapiens 21-24 15337375-4 2004 It is suggested that NPY may influence ethanol consumption by regulating basal levels of anxiety, by modulating the sedative effects of ethanol, and/or by modulating ethanol"s rewarding properties. Ethanol 136-143 neuropeptide Y Homo sapiens 21-24 14691375-0 2003 Intra-amygdala infusion of the NPY Y1 receptor antagonist BIBP 3226 attenuates operant ethanol self-administration. Ethanol 87-94 neuropeptide Y Homo sapiens 31-34 12818714-1 2003 This article is based on proceedings of a symposium presented at the 2002 meeting of the Society for the Study of Ingestive Behavior and provides a brief overview of recent research suggesting a role for neuropeptide Y (NPY) in the modulation of ethanol drinking. Ethanol 246-253 neuropeptide Y Homo sapiens 204-218 12818714-1 2003 This article is based on proceedings of a symposium presented at the 2002 meeting of the Society for the Study of Ingestive Behavior and provides a brief overview of recent research suggesting a role for neuropeptide Y (NPY) in the modulation of ethanol drinking. Ethanol 246-253 neuropeptide Y Homo sapiens 220-223