PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16009465-0 2005 Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Ethanol 86-93 adenylate cyclase activating polypeptide 1 Mus musculus 11-16 16009465-6 2005 However, cultured cerebellar neurons from PACAP-deficient mice were significantly more sensitive than wild type neurons to ethanol- or hydrogen peroxide-induced toxicity. Ethanol 123-130 adenylate cyclase activating polypeptide 1 Mus musculus 42-47 16009465-7 2005 Differential ethanol toxicity was reversed by addition of 100 nM exogenous PACAP, suggesting that endogenous PACAP has neuroprotective activity in the context of cellular insult or stress. Ethanol 13-20 adenylate cyclase activating polypeptide 1 Mus musculus 75-80 16009465-7 2005 Differential ethanol toxicity was reversed by addition of 100 nM exogenous PACAP, suggesting that endogenous PACAP has neuroprotective activity in the context of cellular insult or stress. Ethanol 13-20 adenylate cyclase activating polypeptide 1 Mus musculus 109-114 15518898-0 2004 Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice. Ethanol 46-53 adenylate cyclase activating polypeptide 1 Mus musculus 57-62 15518898-2 2004 The structure of PACAP is highly conserved during evolution, and in Drosophila, loss-of-function mutations in a PACAP-like neuropeptide gene, amnesiac, result in impairment of memory retention and increased sensitivity to ethanol. Ethanol 222-229 adenylate cyclase activating polypeptide 1 Mus musculus 112-117 15518898-3 2004 In mice, PACAP deficiency is associated with impaired memory performance and hippocampal long-term potentiation (LTP), however, sensitivity to ethanol has not been well investigated. Ethanol 143-150 adenylate cyclase activating polypeptide 1 Mus musculus 9-14 15518898-6 2004 Ethanol-induced hypothermia in wild-type control mice was significantly reduced in PACAP-deficient mice. Ethanol 0-7 adenylate cyclase activating polypeptide 1 Mus musculus 83-88 15518898-9 2004 However, in both cases, PACAP or amnesiac products are likely to play significant roles in modifying the intoxicating effects of ethanol. Ethanol 129-136 adenylate cyclase activating polypeptide 1 Mus musculus 24-29 27826748-0 2017 PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks. Ethanol 56-63 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 27826748-2 2017 To explore the capacity of endogenous PACAP to prevent ethanol toxicity, adolescent and adult PACAP knockout (KO) mice were injected with ethanol in a binge drinking-like manner. Ethanol 55-62 adenylate cyclase activating polypeptide 1 Mus musculus 38-43 27826748-3 2017 Biochemical analyses revealed that ethanol administration induced an increase in the production of reactive oxygen species and the activity of caspase-3 in PACAP KO mice in an age-independent manner. Ethanol 35-42 adenylate cyclase activating polypeptide 1 Mus musculus 156-161 27826748-4 2017 In order to characterize the mechanisms underlying the sensitivity of PACAP KO mice, a whole-genome microarray analysis was performed to compare gene regulations induced by ethanol in adolescent and adult wild-type and PACAP KO mice. Ethanol 173-180 adenylate cyclase activating polypeptide 1 Mus musculus 70-75 27826748-7 2017 These data imply that ethanol induces serious DNA damages and cell cycle alteration in PACAP KO mice. Ethanol 22-29 adenylate cyclase activating polypeptide 1 Mus musculus 87-92 27826748-8 2017 This hypothesis, based on the transcriptomic data, could be confirmed by functional studies which showed that cell proliferation decreased in adolescent and adult PACAP KO mice treated with ethanol but recovered after a 30-day withdrawal period. Ethanol 190-197 adenylate cyclase activating polypeptide 1 Mus musculus 163-168 19944672-0 2010 Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice. Ethanol 80-87 adenylate cyclase activating polypeptide 1 Mus musculus 111-116 19944672-1 2010 Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice display remarkable behavioral changes including increased novelty-seeking behavior and reduced hypothermia induced by either serotonin (5-HT)(1A) receptor agonists or ethanol. Ethanol 241-248 adenylate cyclase activating polypeptide 1 Mus musculus 0-50 19944672-1 2010 Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice display remarkable behavioral changes including increased novelty-seeking behavior and reduced hypothermia induced by either serotonin (5-HT)(1A) receptor agonists or ethanol. Ethanol 241-248 adenylate cyclase activating polypeptide 1 Mus musculus 52-57 19944672-3 2010 PACAP-deficient mice showed an increased preference towards ethanol compared with wild-type mice. Ethanol 60-67 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 19944672-7 2010 These results demonstrate increased ethanol preference in PACAP-deficient mice that may be mediated by 5-HT(1A) receptor-dependent attenuation of ethanol-induced central inhibition. Ethanol 36-43 adenylate cyclase activating polypeptide 1 Mus musculus 58-63 19944672-7 2010 These results demonstrate increased ethanol preference in PACAP-deficient mice that may be mediated by 5-HT(1A) receptor-dependent attenuation of ethanol-induced central inhibition. Ethanol 146-153 adenylate cyclase activating polypeptide 1 Mus musculus 58-63 34481915-2 2021 PACAP exerts anti-oxidative and neuroprotective activities on neuronal cells, and prevents ethanol neurotoxicity. Ethanol 91-98 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 34481915-7 2021 Intrauterine administration of PACAP during the gestational period restored the endogenous antioxidant system, prevented ROS overproduction and promoted the survival of dissociated cells from animals prenatally exposed to ethanol. Ethanol 222-229 adenylate cyclase activating polypeptide 1 Mus musculus 31-36