PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16713055-4 2006 We now report that a competent NOS2 with l-arginine can, like NOS1, oxidize EtOH to CH3*CHOH. Ethanol 76-80 nitric oxide synthase 2 Homo sapiens 31-35 24528133-7 2014 Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions. Ethanol 5-12 nitric oxide synthase 2 Homo sapiens 138-142 18845238-3 2008 Here, we present the evidence that metabolism of ethanol in primary human neurons by alcohol dehydrogenase (ADH) or cytochrome P450-2E1 (CYP2E1) generates reactive oxygen species (ROS) and nitric oxide (NO) via induction of NADPH/xanthine oxidase (NOX/XOX) and nitric oxide synthase (NOS) in human neurons. Ethanol 49-56 nitric oxide synthase 2 Homo sapiens 261-282 18690862-5 2007 Either acute or chronic EtOH ingestion affects inducible NO synthase (iNOS) activity. Ethanol 24-28 nitric oxide synthase 2 Homo sapiens 47-68 18690862-5 2007 Either acute or chronic EtOH ingestion affects inducible NO synthase (iNOS) activity. Ethanol 24-28 nitric oxide synthase 2 Homo sapiens 70-74 18690862-6 2007 However it seems that EtOH suppresses induced-NO production by inhibition of iNOS in different cells. Ethanol 22-26 nitric oxide synthase 2 Homo sapiens 77-81 16713055-6 2006 These observations suggest that NOS2 can behave similarly to cytochrome P-450 in the catalysis of acetaldehyde formation from ethanol via the generation of alpha-hydroxyethyl radical when L-arginine is present. Ethanol 126-133 nitric oxide synthase 2 Homo sapiens 32-36 15282113-0 2004 Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: evidence for a transcriptional mechanism. Ethanol 6-13 nitric oxide synthase 2 Homo sapiens 47-78 16272348-9 2005 Furthermore, by using either anti-TLR4- or anti-IL-1RI-neutralizing Abs, before and during ethanol treatment, we inhibit ethanol-induced signaling events, including NF-kappaB and AP-1 activation, inducible NO synthase, and cyclooxygenase-2 up-regulation and astrocyte death. Ethanol 121-128 nitric oxide synthase 2 Homo sapiens 196-217 16272348-7 2005 Then an activation of NF-kappaB and AP-1 occurs after 30 min of ethanol treatment along with an up-regulation of inducible NO synthase and cyclooxygenase-2 expression. Ethanol 64-71 nitric oxide synthase 2 Homo sapiens 113-134 15282113-3 2004 Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol. Ethanol 242-249 nitric oxide synthase 2 Homo sapiens 116-120 15282113-3 2004 Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol. Ethanol 296-303 nitric oxide synthase 2 Homo sapiens 116-120 15282113-4 2004 In the work reported in this article, we tested the working hypothesis that ethanol acts transcriptionally to modulate cytokine-induced expression of the iNOS gene, NOS2A, in human astroglia. Ethanol 76-83 nitric oxide synthase 2 Homo sapiens 154-158 15282113-4 2004 In the work reported in this article, we tested the working hypothesis that ethanol acts transcriptionally to modulate cytokine-induced expression of the iNOS gene, NOS2A, in human astroglia. Ethanol 76-83 nitric oxide synthase 2 Homo sapiens 165-170 15282113-7 2004 However, when cells were simultaneously exposed to ethanol and cytokines for 12 h, in vivo iNOS activity was altered. Ethanol 51-58 nitric oxide synthase 2 Homo sapiens 91-95 15282113-8 2004 That ethanol must be present during cytokine stimulation to influence iNOS activity is consistent with a transcriptional mechanism of action. Ethanol 5-12 nitric oxide synthase 2 Homo sapiens 70-74 15282113-9 2004 In addition, steady-state expression of iNOS protein and NOS2A mRNA levels were modulated in a biphasic manner by ethanol similar to that noted previously for iNOS activity. Ethanol 114-121 nitric oxide synthase 2 Homo sapiens 40-44 15282113-9 2004 In addition, steady-state expression of iNOS protein and NOS2A mRNA levels were modulated in a biphasic manner by ethanol similar to that noted previously for iNOS activity. Ethanol 114-121 nitric oxide synthase 2 Homo sapiens 57-62 15282113-10 2004 These findings strongly support the suggestion that ethanol modulates cytokine-induced iNOS expression in A172 cells at a pretranslational site. Ethanol 52-59 nitric oxide synthase 2 Homo sapiens 87-91 15282113-11 2004 These findings should be instrumental in the identification of the critical ethanol-sensitive elements involved in the regulation of NOS2A in human astroglia. Ethanol 76-83 nitric oxide synthase 2 Homo sapiens 133-138 15094475-0 2004 Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 16-20 15094475-3 2004 By using cultured cortical astrocytes, we show that a short ethanol treatment (100 mM) is able to up-regulate both cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, and that these effects are regulated via nuclear factor kappa B (NF-kappa B) as revealed by the inhibition of NF-kappa B activation with pyrrolidine dithiocarbamate (PDTC) or BAY 11-7082. Ethanol 60-67 nitric oxide synthase 2 Homo sapiens 144-175 15094475-3 2004 By using cultured cortical astrocytes, we show that a short ethanol treatment (100 mM) is able to up-regulate both cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, and that these effects are regulated via nuclear factor kappa B (NF-kappa B) as revealed by the inhibition of NF-kappa B activation with pyrrolidine dithiocarbamate (PDTC) or BAY 11-7082. Ethanol 60-67 nitric oxide synthase 2 Homo sapiens 177-181 12351936-13 2002 Acute (6-24 hr) exposure of activated cells to 50 mM ethanol enhanced iNOS activity recovered from the cytosol, whereas 200 mM ethanol decreased it. Ethanol 53-60 nitric oxide synthase 2 Homo sapiens 70-74 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 26-33 nitric oxide synthase 2 Homo sapiens 202-223 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 26-33 nitric oxide synthase 2 Homo sapiens 225-229 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 77-84 nitric oxide synthase 2 Homo sapiens 202-223 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 77-84 nitric oxide synthase 2 Homo sapiens 225-229 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 77-84 nitric oxide synthase 2 Homo sapiens 202-223 12237742-3 2002 This inhibitory effect of ethanol on NO production was almost abolished when ethanol was added to the medium 12 h after the start of incubation with LPS, implying that ethanol inhibits the induction of inducible NO synthase (iNOS). Ethanol 77-84 nitric oxide synthase 2 Homo sapiens 225-229 12237742-4 2002 Both LPS-induced protein and mRNA expression of iNOS were inhibited by ethanol (100-600 mM) concentration-dependently. Ethanol 71-78 nitric oxide synthase 2 Homo sapiens 48-52 12351936-4 2002 Evidence of ethanol-induced effects on iNOS in human glial cells is nonexistent. Ethanol 12-19 nitric oxide synthase 2 Homo sapiens 39-43 12351936-5 2002 Herein, the conditions necessary for significant iNOS induction in human A172 astrocytoma cells have been characterized, and subsequently, the effects of ethanol on iNOS expression have been investigated. Ethanol 154-161 nitric oxide synthase 2 Homo sapiens 165-169 12351936-9 2002 Time-course (6-24 hr) studies assessed the effects of ethanol (50-200 mM) on iNOS induction. Ethanol 54-61 nitric oxide synthase 2 Homo sapiens 77-81 12351936-15 2002 CONCLUSIONS: The present study is the first published report of ethanol-induced modulation of iNOS expression in human glial cells. Ethanol 64-71 nitric oxide synthase 2 Homo sapiens 94-98 12351936-16 2002 The data suggest that ethanol is influencing iNOS enzyme levels most profoundly. Ethanol 22-29 nitric oxide synthase 2 Homo sapiens 45-49 10945852-6 2000 We found that EtOH caused 1) iNOS activation, 2) NO overproduction, 3) increases in oxidative stress and superoxide anion production (superoxide dismutase quenchable fluorescence of dichlorofluorescein), 4) nitration and oxidation of tubulin (immunoblotting), 5) decreased levels of stable polymerized tubulin, and 6) increased levels of disassembled tubulin. Ethanol 14-18 nitric oxide synthase 2 Homo sapiens 29-33 11173986-0 2001 Ethanol inhibits cytokine-induced iNOS and sPLA2 in immortalized astrocytes: evidence for posttranscriptional site of ethanol action. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 34-38 11173986-4 2001 In this study, we investigate the effects of ethanol on cytokine-induced iNOS and sPLA2 in immortalized astrocytes (DITNC). Ethanol 45-52 nitric oxide synthase 2 Homo sapiens 73-77 11173986-7 2001 The inhibitory effect of ethanol on NO production corresponds well with the decrease in iNOS protein and NOS enzyme activity, but not with iNOS and sPLA2 mRNA nor binding of NF-kappaB to DNA. Ethanol 25-32 nitric oxide synthase 2 Homo sapiens 88-92 11194055-6 2000 Level of iNOS expression was measured in the ethanol-treated populations using an anti-iNOS primary antibody with a fluorescent labeled secondary antibody. Ethanol 45-52 nitric oxide synthase 2 Homo sapiens 9-13 11194055-6 2000 Level of iNOS expression was measured in the ethanol-treated populations using an anti-iNOS primary antibody with a fluorescent labeled secondary antibody. Ethanol 45-52 nitric oxide synthase 2 Homo sapiens 87-91 11194055-8 2000 Our data indicate that ethanol demonstrates a stimulation and simultaneous inhibition of iNOS during an 8-h incubation. Ethanol 23-30 nitric oxide synthase 2 Homo sapiens 89-93 11994208-4 2002 iNOS gene expression in these cells is modulated by LPS+EtOH in a gender- dependent manner. Ethanol 56-60 nitric oxide synthase 2 Homo sapiens 0-4 11787762-21 2001 We conclude that LPS applied centrally or peripherally protects gastric mucosa against ethanol-induced damage through an increase in gastric microcirculation mediated by NO due to overexpression of iNOS. Ethanol 87-94 nitric oxide synthase 2 Homo sapiens 198-202 10945852-10 2000 We conclude that EtOH-induced MT damage and intestinal barrier dysfunction require iNOS activation followed by NO overproduction and ONOO(-) formation. Ethanol 17-21 nitric oxide synthase 2 Homo sapiens 83-87 9762419-2 1998 In this study, we investigated the activity of a key apoptotic protease, caspase-3, and the expression of nitric oxide synthase-2 (NOS-2) associated with buccal epithelial cells apoptosis induced by chronic ethanol diet. Ethanol 207-214 nitric oxide synthase 2 Homo sapiens 106-129 10614774-11 1999 Moreover, ethanol enhanced neutrophil expression of inducible NO synthase. Ethanol 10-17 nitric oxide synthase 2 Homo sapiens 52-73 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 nitric oxide synthase 2 Homo sapiens 101-105 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 nitric oxide synthase 2 Homo sapiens 271-275 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 nitric oxide synthase 2 Homo sapiens 101-105 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 nitric oxide synthase 2 Homo sapiens 271-275 10442856-9 1999 Because IFN-gamma and IL-1beta are produced by intestinal immune cells, these findings may have implications for differential in vivo regulation of epithelial iNOS genes by ethanol, depending on the inflammatory and immune status of the host. Ethanol 173-180 nitric oxide synthase 2 Homo sapiens 159-163 10205016-2 1999 Ethanol inhibits inducible nitric oxide synthase (iNOS) expression in C6 glioma cells by an unknown mechanism. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 17-48 10205016-2 1999 Ethanol inhibits inducible nitric oxide synthase (iNOS) expression in C6 glioma cells by an unknown mechanism. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 50-54 10205016-18 1999 In conclusion, inhibition of iNOS expression by ethanol and other short chain alkanols is not due to cytotoxicity. Ethanol 48-55 nitric oxide synthase 2 Homo sapiens 29-33 10688896-3 2000 EtOH also inhibited NO production, indicative of a suppression of nitric oxide synthase (NOS) activity. Ethanol 0-4 nitric oxide synthase 2 Homo sapiens 66-87 10442856-0 1999 Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. Ethanol 78-85 nitric oxide synthase 2 Homo sapiens 27-58 10442856-1 1999 We have examined the regulation of inducible nitric oxide synthase (iNOS) gene expression by ethanol in monolayers of DLD-1 cells, an epithelial cell line derived from human intestinal adenocarcinoma. Ethanol 93-100 nitric oxide synthase 2 Homo sapiens 35-66 10442856-1 1999 We have examined the regulation of inducible nitric oxide synthase (iNOS) gene expression by ethanol in monolayers of DLD-1 cells, an epithelial cell line derived from human intestinal adenocarcinoma. Ethanol 93-100 nitric oxide synthase 2 Homo sapiens 68-72 10442856-7 1999 Conditioned medium from ethanol-treated cells increased the IFN-gamma-induced iNOS mRNA of naive cells by threefold. Ethanol 24-31 nitric oxide synthase 2 Homo sapiens 78-82 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 25-32 nitric oxide synthase 2 Homo sapiens 101-105 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 25-32 nitric oxide synthase 2 Homo sapiens 271-275 9762419-2 1998 In this study, we investigated the activity of a key apoptotic protease, caspase-3, and the expression of nitric oxide synthase-2 (NOS-2) associated with buccal epithelial cells apoptosis induced by chronic ethanol diet. Ethanol 207-214 nitric oxide synthase 2 Homo sapiens 131-136 9665319-0 1998 Role of PKC and tyrosine kinase in ethanol-mediated inhibition of LPS-inducible nitric oxide synthase. Ethanol 35-42 nitric oxide synthase 2 Homo sapiens 70-101 9665319-1 1998 Ethanol increases human and animal susceptibility to opportunistic lung infections in part by suppression of endotoxin (LPS) and bacteria-mediated upregulation of inducible nitric oxide synthase (iNOS) in alveolar macrophages (AM). Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 163-194 9665319-8 1998 ETOH inhibits LPS-induced upregulation of iNOS mRNA by preventing its ability to decrease PKCdelta and upregulate tyrosine kinase-mediated phosphorylation. Ethanol 0-4 nitric oxide synthase 2 Homo sapiens 42-46 9665319-10 1998 The data support the hypothesis that ETOH inhibits LPS-induced upregulation of iNOS mRNA by interfering with the phosphorylation processes involved in activation of the nuclear transcription factors NFkappaB and AP-1. Ethanol 37-41 nitric oxide synthase 2 Homo sapiens 79-83 9665319-1 1998 Ethanol increases human and animal susceptibility to opportunistic lung infections in part by suppression of endotoxin (LPS) and bacteria-mediated upregulation of inducible nitric oxide synthase (iNOS) in alveolar macrophages (AM). Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 196-200 7541951-2 1995 We have previously reported that EtOH suppressed gene expression for inducible nitric oxide synthase (iNOS) with a subsequent decrease in release of reactive nitrogen intermediates by alveolar macrophages and recruited lung neutrophils. Ethanol 33-37 nitric oxide synthase 2 Homo sapiens 69-100 9727648-1 1998 This study reviews the putative mechanism of ethanol (ETOH)-mediated downregulation of inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein and upregulation of constitutive NOS activity (ecNOS) in immunocompetent cells and endothelium, in vivo. Ethanol 45-52 nitric oxide synthase 2 Homo sapiens 87-118 9727648-1 1998 This study reviews the putative mechanism of ethanol (ETOH)-mediated downregulation of inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein and upregulation of constitutive NOS activity (ecNOS) in immunocompetent cells and endothelium, in vivo. Ethanol 45-52 nitric oxide synthase 2 Homo sapiens 120-124 9727648-1 1998 This study reviews the putative mechanism of ethanol (ETOH)-mediated downregulation of inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein and upregulation of constitutive NOS activity (ecNOS) in immunocompetent cells and endothelium, in vivo. Ethanol 54-58 nitric oxide synthase 2 Homo sapiens 87-118 9727648-1 1998 This study reviews the putative mechanism of ethanol (ETOH)-mediated downregulation of inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein and upregulation of constitutive NOS activity (ecNOS) in immunocompetent cells and endothelium, in vivo. Ethanol 54-58 nitric oxide synthase 2 Homo sapiens 120-124 9727648-4 1998 Also, ETOH-mediated attenuation of endotoxin-induced downregulation of nuclear protein kinase C activity appears to decrease the stability of expressed iNOS mRNA. Ethanol 6-10 nitric oxide synthase 2 Homo sapiens 152-156 9808068-4 1998 The goal of the present study was to examine the effects of ethanol on NO production and mRNA expression of iNOS following its induction by bacterial endotoxin lipopolysaccharide (LPS) in cultured glial cells. Ethanol 60-67 nitric oxide synthase 2 Homo sapiens 108-112 9808068-8 1998 Using a semiquantitative reverse transcriptase polymerase chain reaction, we found that while ethanol by itself was unable to induce iNOS mRNA, it nevertheless suppressed LPS-induced iNOS mRNA expression. Ethanol 94-101 nitric oxide synthase 2 Homo sapiens 183-187 9808068-10 1998 These findings suggest that ethanol may ameliorate the consequences of overwhelming NO generation through iNOS induction in glial cells following infection, inflammation or CNS injuries. Ethanol 28-35 nitric oxide synthase 2 Homo sapiens 106-110 9727648-0 1998 The potential mechanism of induction of inducible nitric oxide synthase mRNA in alveolar macrophages by lipopolysaccharide and its suppression by ethanol, in vivo. Ethanol 146-153 nitric oxide synthase 2 Homo sapiens 40-71 9103544-2 1997 Ethanol dose-dependently inhibits C6 cell NOS-2 activity, as measured by nitrite accumulation in culture medium, when present during LPS plus PMA treatment. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 42-47 9103544-5 1997 In contrast, NOS-2 enzymatic activity was significantly decreased in cytosolic extracts from cultures simultaneously exposed to ethanol and LPS plus PMA for 24 hr. Ethanol 128-135 nitric oxide synthase 2 Homo sapiens 13-18 9103544-7 1997 RNA analysis revealed that NOS-2 mRNA was decreased at both 12 and 24 hr during LPS plus PMA induction in the presence of ethanol. Ethanol 122-129 nitric oxide synthase 2 Homo sapiens 27-32 9103544-8 1997 Subsequent experiments confirmed that 12-hr exposure to ethanol was sufficient to inhibit LPS/PMA-induced NOS-2 activity. Ethanol 56-63 nitric oxide synthase 2 Homo sapiens 106-111 9103544-9 1997 Ethanol exposure also inhibited NOS-2 activity induced by LPS plus interferon-gamma, by LPS plus tumor necrosis factor-alpha and by tumor necrosis factor-alpha alone. Ethanol 0-7 nitric oxide synthase 2 Homo sapiens 32-37 9103544-10 1997 These data point to an inhibitory ethanol effect at a site downstream from cytokine receptor activation and second messenger signal transduction mechanisms leading to suppression of NOS-2 gene expression in C6 cells. Ethanol 34-41 nitric oxide synthase 2 Homo sapiens 182-187 7541951-2 1995 We have previously reported that EtOH suppressed gene expression for inducible nitric oxide synthase (iNOS) with a subsequent decrease in release of reactive nitrogen intermediates by alveolar macrophages and recruited lung neutrophils. Ethanol 33-37 nitric oxide synthase 2 Homo sapiens 102-106 34769415-6 2021 In addition, pretreatment with naringenin might inhibit the secretion of TNF-alpha, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-kappaB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells. Ethanol 282-289 nitric oxide synthase 2 Homo sapiens 186-190 7525932-0 1994 Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. Ethanol 30-37 nitric oxide synthase 2 Homo sapiens 84-105 33895940-8 2021 We found that activation of endothelial nitric oxide synthase (eNOS) under low-dose ethanol conditions with a shift to activation of inducible NOS (iNOS) under chronic high ethanol exposure conditions, which appeared to regulate these contrasting effects. Ethanol 84-91 nitric oxide synthase 2 Homo sapiens 133-146 33895940-8 2021 We found that activation of endothelial nitric oxide synthase (eNOS) under low-dose ethanol conditions with a shift to activation of inducible NOS (iNOS) under chronic high ethanol exposure conditions, which appeared to regulate these contrasting effects. Ethanol 173-180 nitric oxide synthase 2 Homo sapiens 133-146 33895940-8 2021 We found that activation of endothelial nitric oxide synthase (eNOS) under low-dose ethanol conditions with a shift to activation of inducible NOS (iNOS) under chronic high ethanol exposure conditions, which appeared to regulate these contrasting effects. Ethanol 173-180 nitric oxide synthase 2 Homo sapiens 148-152 33895940-10 2021 We concluded that the effects of low-dose ethanol increased the diffusive movement of waste metabolites via eNOS-derived NO, which increased the arterial endothelial-smooth muscle cell dilative reactivity without affecting BBB integrity, whereas a prolonged induction of iNOS under chronic ethanol exposure conditions caused oxidative damage of the arterial endothelial-smooth muscle layers resulting in cerebral amyloid-like angiopathy. Ethanol 42-49 nitric oxide synthase 2 Homo sapiens 271-275 28608757-0 2018 The effect of ethanol and N-nitrosodimethylamine on the iNOS-dependent NO production in human neutrophils. Ethanol 14-21 nitric oxide synthase 2 Homo sapiens 56-60 28608757-3 2018 The objective of study was to determine the influence of ethanol and/or N-nitrosodimethyloamine (NDMA) on the inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production by human neutrophils and determination of the role of NF-kappaB in this process. Ethanol 57-64 nitric oxide synthase 2 Homo sapiens 110-141 28608757-3 2018 The objective of study was to determine the influence of ethanol and/or N-nitrosodimethyloamine (NDMA) on the inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production by human neutrophils and determination of the role of NF-kappaB in this process. Ethanol 57-64 nitric oxide synthase 2 Homo sapiens 143-147 28608757-9 2018 In neutrophils exposed to ethanol or NDMA was observed an increased NF-kappaB-dependent NO production mediated by iNOS with the contribution of MAP kinases: p38 and JNK. Ethanol 26-33 nitric oxide synthase 2 Homo sapiens 114-118