PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33561510-2 2021 In the brain ethanol can be detrimental to memory formation, through inducing the integrated stress response/endoplasmic reticulum stress/unfolded protein response and the molecular mechanisms linking stress to other events such as NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammation and autophagy. Ethanol 13-20 NLR family pyrin domain containing 3 Homo sapiens 232-280 33561510-2 2021 In the brain ethanol can be detrimental to memory formation, through inducing the integrated stress response/endoplasmic reticulum stress/unfolded protein response and the molecular mechanisms linking stress to other events such as NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammation and autophagy. Ethanol 13-20 NLR family pyrin domain containing 3 Homo sapiens 282-287 33561510-3 2021 This literature review aims to provide an overview of our current understanding of the molecular mechanisms involved in ethanol-induced damage with endoplasmic reticulum stress, integrated stress response, NLRP3 inflammation and autophagy, while discussing the impact of neurosteroids and oxysterols, including allopregnanolone, 25-hydroxycholesterol and 24S-hydroxycholesterol, on the central nervous system. Ethanol 120-127 NLR family pyrin domain containing 3 Homo sapiens 206-211 32787872-2 2020 Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, closely associated with the pathogenesis of neurodegeneration. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 40-67 32787872-2 2020 Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, closely associated with the pathogenesis of neurodegeneration. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 69-74 32787872-4 2020 Therefore, the present study investigated the detailed mechanism of calcium-regulated mitochondrial dynamics and NLRP3 inflammasome formation in neuronal cells by ethanol. Ethanol 163-170 NLR family pyrin domain containing 3 Homo sapiens 113-118 32787872-13 2020 Ethanol-induced JNK1 phosphorylation activated the NLRP3 inflammasome that induced caspase-1 dependent mitophagy inhibition, thereby exacerbating ROS accumulation and causing cell death. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 51-56 32787872-15 2020 CONCLUSIONS: Our results demonstrated that ethanol upregulated NMDAR-dependent CaMKII phosphorylation which is essential for Drp1-mediated excessive mitochondrial fission and the JNK1-induced NLRP3 inflammasome activation resulting in neuronal apoptosis. Ethanol 43-50 NLR family pyrin domain containing 3 Homo sapiens 192-197 32469177-0 2020 Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 42-47 32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Ethanol 61-68 NLR family pyrin domain containing 3 Homo sapiens 95-131 32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Ethanol 61-68 NLR family pyrin domain containing 3 Homo sapiens 133-138 32469177-3 2020 MATERIALS AND METHODS: Human myeloid leukemia cells (U937 cells) were used to assess the role of ethanol in NLRP3 inflammasome activation induced by monosodium urate (MSU) crystals. Ethanol 97-104 NLR family pyrin domain containing 3 Homo sapiens 108-113 32469177-5 2020 The effect of ethanol-induced TXNIP on the NLRP3 inflammasome was assessed in human macrophages transfected with TXNIP siRNA. Ethanol 14-21 NLR family pyrin domain containing 3 Homo sapiens 43-48 32469177-6 2020 RESULTS: U937 cells treated with 100 mM ethanol for 24 h induced NLRP3 and interleukin (IL)-1beta expression. Ethanol 40-47 NLR family pyrin domain containing 3 Homo sapiens 65-70 32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Ethanol 15-22 NLR family pyrin domain containing 3 Homo sapiens 33-38 32469177-10 2020 Treatment with 100mM ethanol for 24 h downregulated NLRP3 and IL-1beta expression in MSU crystal-activated U937 cells transfected with TXNIP siRNA, compared to those with scramble siRNA. Ethanol 21-28 NLR family pyrin domain containing 3 Homo sapiens 52-57 32469177-11 2020 CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. Ethanol 12-19 NLR family pyrin domain containing 3 Homo sapiens 49-54 31646907-5 2019 This knowledge, enriched by a focus on the immunomodulatory effects of ethanol and its metabolites, in particular on the NLRP3 inflammasome pathway, might facilitate the development of treatments that can reduce ethanol"s harmful effects or accentuate its beneficial effects. Ethanol 71-78 NLR family pyrin domain containing 3 Homo sapiens 121-126 31646907-5 2019 This knowledge, enriched by a focus on the immunomodulatory effects of ethanol and its metabolites, in particular on the NLRP3 inflammasome pathway, might facilitate the development of treatments that can reduce ethanol"s harmful effects or accentuate its beneficial effects. Ethanol 212-219 NLR family pyrin domain containing 3 Homo sapiens 121-126 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Ethanol 23-30 NLR family pyrin domain containing 3 Homo sapiens 113-118 31272469-8 2019 RESULTS: We show that ethanol increases the number of secreted nanovesicles and their content by raising the levels of both inflammatory-related proteins (TLR4, NFkappaB-p65, IL-1R, caspase-1, NLRP3) and by changing miRNAs (mir-146a, mir-182, and mir-200b) in the EVs from the WT-astrocytes compared with those from the untreated WT cells. Ethanol 22-29 NLR family pyrin domain containing 3 Homo sapiens 193-198 29475852-13 2019 Consequently, treatment of hepatocytes with ethanol resulted in TXNIP overexpression, activating NLRP3 inflammasome and caspase-1-mediated pyroptosis. Ethanol 44-51 NLR family pyrin domain containing 3 Homo sapiens 97-102 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 36-43 NLR family pyrin domain containing 3 Homo sapiens 98-171 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 36-43 NLR family pyrin domain containing 3 Homo sapiens 173-178 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 215-222 NLR family pyrin domain containing 3 Homo sapiens 98-171 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 215-222 NLR family pyrin domain containing 3 Homo sapiens 173-178 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 215-222 NLR family pyrin domain containing 3 Homo sapiens 98-171 30447168-2 2019 In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Ethanol 215-222 NLR family pyrin domain containing 3 Homo sapiens 173-178 30447168-3 2019 Purinergic receptors (especially the P2X7 receptor) are able to activate the NLRP3 inflammasome and are involved in many ethanol-related diseases (such as gout, pulmonary fibrosis, alcoholic steatohepatitis, and certain cancers). Ethanol 121-128 NLR family pyrin domain containing 3 Homo sapiens 77-82 30447168-4 2019 We hypothesized that ethanol regulates purinergic receptors and thus modulates the NLRP3 inflammasome"s activity. Ethanol 21-28 NLR family pyrin domain containing 3 Homo sapiens 83-88 30447168-8 2019 Taken as a whole, our results suggest that ethanol induces NLRP3 inflammasome activation by upregulating the P2X7 receptor. Ethanol 43-50 NLR family pyrin domain containing 3 Homo sapiens 59-64 29338075-9 2018 In ethanol-exposed HepG2 cells, gentiopicroside reduced lipogenesis and promoted lipid oxidation via activation of P2X7 receptor-NLRP3 inflammasomes. Ethanol 3-10 NLR family pyrin domain containing 3 Homo sapiens 129-134 27650785-7 2016 Elimination of TLR4 and NLRP3 abolishes many neuroimmune effects of EtOH. Ethanol 68-72 NLR family pyrin domain containing 3 Homo sapiens 24-29 27160314-0 2016 Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 35-40 27160314-5 2016 Ethanol exposure for 24 hours or 7 days does not affect the proliferation of iPS cells and NPCs, but primes an innate immune-like response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 195-200 24244322-0 2013 Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages--a novel anti-inflammatory action of alcohol. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 31-36 24244322-4 2013 RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin. Ethanol 9-16 NLR family pyrin domain containing 3 Homo sapiens 107-112 24244322-10 2013 CONCLUSION: Ethanol-induced inhibition of the NLRP3 inflammasome activation in macrophages may represent a biological pathway underlying the protective effect of moderate alcohol consumption on coronary heart disease. Ethanol 12-19 NLR family pyrin domain containing 3 Homo sapiens 46-51 22661925-7 2012 Ethanol-impaired neurogenesis is associated with strong induction of IL-1beta and inflammasome proteins NALP1 and NALP3 in both neurons and astrocytes. Ethanol 0-7 NLR family pyrin domain containing 3 Homo sapiens 114-119