PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9400717-7	1997	In addition to a TNF-alpha-mediated pathway, there is growing evidence that some particles such as quartz and crocidolite can directly activate lung epithelial cells to release chemokines such as macrophage inflammatory protein-2, cytokine-induced neutrophil chemoattractant, and interleukin-8.	Asbestos, Crocidolite	110-121	C-X-C motif chemokine ligand 8	Homo sapiens	280-293	
1556187-2	1992	We found that instillation of crocidolite asbestos into the pleural space of rabbits led to the appearance in pleural liquid of chemotactic activity for neutrophils, and that this chemotactic activity was inhibited significantly by a neutralizing antibody to human interleukin 8 (IL-8).	Asbestos, Crocidolite	30-50	C-X-C motif chemokine ligand 8	Homo sapiens	265-278	
8720280-7	1996	In vitro experiments confirmed that crocidolite or chrysotile asbestos could stimulate the release of IL-8 from mononuclear phagocytes in a dose-dependent fashion.	Asbestos, Crocidolite	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	102-106	
8117443-4	1994	Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at 37 degrees C. Electron microscopy of asbestos-treated HPMC showed that the cells avidly engulfed each of the different types of asbestos fibers.	Asbestos, Crocidolite	39-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128	
8117443-7	1994	Preincubation of HPMC with IL-1 receptor antagonist (IL-1ra) significantly decreased release of IL-8 after stimulation with amosite or crocidolite asbestos.	Asbestos, Crocidolite	135-155	C-X-C motif chemokine ligand 8	Homo sapiens	96-100	
1556187-2	1992	We found that instillation of crocidolite asbestos into the pleural space of rabbits led to the appearance in pleural liquid of chemotactic activity for neutrophils, and that this chemotactic activity was inhibited significantly by a neutralizing antibody to human interleukin 8 (IL-8).	Asbestos, Crocidolite	30-50	C-X-C motif chemokine ligand 8	Homo sapiens	280-284	
17242997-9	2007	Although it is generally assumed that riebeckite particles do not elicit strong biological responses, in our studies in cyclically stretched cell cultures, the riebeckite particles coated with adhesion proteins induced significant IL-8 responses, but in static cell cultures the treatment with adhesion protein-coated riebeckite did not induce comparable cytokine responses.	Asbestos, Crocidolite	160-170	C-X-C motif chemokine ligand 8	Homo sapiens	231-235	
17242997-9	2007	Although it is generally assumed that riebeckite particles do not elicit strong biological responses, in our studies in cyclically stretched cell cultures, the riebeckite particles coated with adhesion proteins induced significant IL-8 responses, but in static cell cultures the treatment with adhesion protein-coated riebeckite did not induce comparable cytokine responses.	Asbestos, Crocidolite	160-170	C-X-C motif chemokine ligand 8	Homo sapiens	231-235	
15952644-1	2005	OBJECTIVE: This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression.	Asbestos, Crocidolite	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P < 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-71	
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P < 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	137-141	
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P < 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	137-141