PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24875119-3 2014 Together with the recent determination of an iron(IV)hydroxide pK(a) ~ 12 in the thiolate-ligated heme enzyme cytochrome P450, this result provides insight into Nature"s ability to tune catalytic function through its choice of axial ligand. hydroxide ion 52-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 110-125 8886602-1 1996 Midazolam (MDZ) is metabolized in human liver microsomes by the cytochrome P450 (CYP) 3A subfamily to 1"-hydroxy (1"-OH) and 4-hydroxy (4-OH) metabolites. hydroxide ion 105-112 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-79