PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35457257-7	2022	By applying this workflow to MMP-9, we proposed two potent natural product inhibitors (laetanine 9 and genkwanin 10) that interact with hotspot residues of the hemopexin domain of MMP-9.	genkwanin	103-112	matrix metallopeptidase 9	Homo sapiens	29-34	
35457257-7	2022	By applying this workflow to MMP-9, we proposed two potent natural product inhibitors (laetanine 9 and genkwanin 10) that interact with hotspot residues of the hemopexin domain of MMP-9.	genkwanin	103-112	matrix metallopeptidase 9	Homo sapiens	180-185	
35457257-8	2022	Laetanine 9 and genkwanin 10 bind to MMP-9 with a dissociation constant (KD) of 21.6 and 0.614 muM, respectively.	genkwanin	16-25	matrix metallopeptidase 9	Homo sapiens	37-42	
35457257-9	2022	Overall, we present laetanine 9 and genkwanin 10 for MMP-9 and demonstrate that the novel FMO-based workflow with a quantum mechanical approach is promising to discover potent natural product inhibitors of MMP-9, satisfying the pharmacophore model and good binding affinity.	genkwanin	36-45	matrix metallopeptidase 9	Homo sapiens	206-211