PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15140212-3	2004	To explore whether PUVA may also be used for gene repression, psoralen was conjugated to a triplex-forming oligonucleotide (TFO) that targets a gene sequence of ICAM-1, a key molecule in cutaneous inflammation.	tfo	124-127	intercellular adhesion molecule 1	Homo sapiens	161-167	
12080053-3	2002	To explore the potential of triplex-forming oligonucleotides (TFOs) as gene repressors, a TFO was designed to target a 16-bp sequence within the third intron of the human intercellular-adhesion molecule-1 (ICAM-1) gene, which plays a key role in initiating inflammation.	tfo	62-65	intercellular adhesion molecule 1	Homo sapiens	171-204	
12080053-4	2002	TFO binding to its ICAM-1 target sequence was characterized in vitro and also demonstrated in cell nuclei with the set-up of a novel magnetic capture assay, which represents a general experimental approach to the detection of specific TFO binding and to the determination of the accessibility of a given genomic DNA locus.	tfo	0-3	intercellular adhesion molecule 1	Homo sapiens	19-25	
12080053-4	2002	TFO binding to its ICAM-1 target sequence was characterized in vitro and also demonstrated in cell nuclei with the set-up of a novel magnetic capture assay, which represents a general experimental approach to the detection of specific TFO binding and to the determination of the accessibility of a given genomic DNA locus.	tfo	235-238	intercellular adhesion molecule 1	Homo sapiens	19-25	
12080053-5	2002	In a human keratinocyte cell line (A431), we observed that: (i) the ICAM-1 target sequence in the chromatin context within the nuclei is still available for triplex formation and (ii) TFO inhibits sequence and gene-specific interferon-gamma-induced ICAM-1 surface expression.	tfo	184-187	intercellular adhesion molecule 1	Homo sapiens	68-74	
12080053-5	2002	In a human keratinocyte cell line (A431), we observed that: (i) the ICAM-1 target sequence in the chromatin context within the nuclei is still available for triplex formation and (ii) TFO inhibits sequence and gene-specific interferon-gamma-induced ICAM-1 surface expression.	tfo	184-187	intercellular adhesion molecule 1	Homo sapiens	249-255	
12080053-6	2002	Collectively, the data demonstrate effective and specific inhibition of ICAM-1 expression by TFO treatment and support the view that triplex-mediated gene targeting might be a valuable technique for anti-inflammatory or anticancer strategies.	tfo	93-96	intercellular adhesion molecule 1	Homo sapiens	72-78