PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16394133-11	2005	Both methods produced quantitatively close results; (125)I-TFO-GA with multiple nuclear targets produced on average 1.93 times more gamma-H2AX foci per cell and generated 1.96 times increase in gamma-H2AX antibody staining signal than (125)I-TFO-HPRT with a single target.	tfo	59-62	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	246-250	
16394133-9	2005	Here we applied this method to evaluate the intracellular DNA damage produced by two (125)I-TFOs, the first targeted to the single-copy HPRT gene ((125)I-TFO-HPRT) and second to a multicopy repeated sequence (GA)(n) that occurs almost 7000 times in the human genome ((125)I-TFO-GA).	tfo	92-95	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	136-140	
16394133-9	2005	Here we applied this method to evaluate the intracellular DNA damage produced by two (125)I-TFOs, the first targeted to the single-copy HPRT gene ((125)I-TFO-HPRT) and second to a multicopy repeated sequence (GA)(n) that occurs almost 7000 times in the human genome ((125)I-TFO-GA).	tfo	92-95	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	158-162	
10481023-1	1999	We studied the stability of a DNA triplex resulting from the binding of a 38 nt long purine motif triplex-forming oligonucleotide (TFO) to a covalently closed plasmid containing a target sequence from the human HPRT gene.	tfo	131-134	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	211-215	
9004758-3	1996	Decay of 125I in the bound TFO was shown to cause sequence-specific double strand breaks (DSB) in the target HPRT sequence cloned into plasmid DNA.	tfo	27-30	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	109-113	
22914677-3	2012	We have engineered a TFO, TFO27, to target the genomic Hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus to define the mutagenic potential of such structures at genomic DNA.	tfo	21-24	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	55-101	
22914677-3	2012	We have engineered a TFO, TFO27, to target the genomic Hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus to define the mutagenic potential of such structures at genomic DNA.	tfo	21-24	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	103-107	
20725628-3	2010	We designed TFO sequences with DNA and 2"-O-methyl RNA backbones conjugated to psoralen by 2-carbon linkers and examined their ability to bind and target damage to model DNA duplexes corresponding to sequences within the human HPRT gene.	tfo	12-15	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	227-231	
18435621-1	2008	A triplex-forming oligonucleotide (TFO), HPRT3, conjugated to a psoralen derivative, was designed to target a psoralen reaction site within the HPRT gene.	tfo	35-38	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	41-45