PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28429235-5	2017	In this study, we investigated the effects of memantine on human brain microvascular endothelial dysfunction induced by the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha).	Memantine	46-55	tumor necrosis factor	Homo sapiens	150-177	
28429235-5	2017	In this study, we investigated the effects of memantine on human brain microvascular endothelial dysfunction induced by the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha).	Memantine	46-55	tumor necrosis factor	Homo sapiens	179-188	
28429235-7	2017	An in vitro BBB model experiment displayed that memantine could rescue TNF-alpha-induced disruption of the in vitro BBB model.	Memantine	48-57	tumor necrosis factor	Homo sapiens	71-80	
28429235-9	2017	Our results indicate that TNF-alpha significantly increased the expression of cell adhesion molecules, such as ICAM-1, VCAM-1, and E-selectin, which was prevented by pretreatment with memantine.	Memantine	184-193	tumor necrosis factor	Homo sapiens	26-35	
24717258-8	2014	Tumor necrosis factor alpha levels were significantly lower in the VPA + memantine group than in the VPA + placebo group (P = 0.013).	Memantine	73-82	tumor necrosis factor	Homo sapiens	0-27	
29796036-4	2018	In this study, we assessed the effect of memantine on the pro-inflammatory cytokines such as IL6, TNFalpha and CRP.	Memantine	41-50	tumor necrosis factor	Homo sapiens	98-106	
24717258-11	2014	Treating bipolar II depression with VPA + memantine may improve the plasma TNF-alpha level.	Memantine	42-51	tumor necrosis factor	Homo sapiens	75-84	
19536110-9	2009	In addition, memantine also displays neuroprotective effects against LPS-induced DA neuronal damage through its inhibition of microglia activation showed by both OX-42 immunostaining and reduction of pro-inflammatory factor production, such as extracellular superoxide anion, intracellular reactive oxygen species, nitric oxide, prostaglandin E(2), and tumor necrosis factor-alpha.	Memantine	13-22	tumor necrosis factor	Homo sapiens	353-380