PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32477103-7	2020	Donepezil and memantine exerted protective effects against CD4+CD28+ cell decrease caused by aging and reduced the pro-inflammatory factors TNF-alpha, IL-1beta, and G-CSF in plasma.	Memantine	14-23	tumor necrosis factor	Mus musculus	140-149	
21277908-6	2011	Interestingly, pretreatment with memantine at the lowest effective dose (0.02 mg/kg/injection) reversed cocaine conditioning-enhanced IL-6 and -decreased TNF-alpha levels in these brain regions.	Memantine	33-42	tumor necrosis factor	Mus musculus	154-163	
15099690-7	2004	Furthermore, combined treatment of these mice with memantine demonstrated that the neurotoxic effects of tumor necrosis factor-alpha upon cholinergic cells did not require the activation of the N-methyl-d-aspartate receptors.	Memantine	51-60	tumor necrosis factor	Mus musculus	105-132	
29366650-4	2018	Among the triptolide derivatives tested, a memantine conjugate, compound 8, showed a remarkable neuroprotective effect against Abeta1-42 toxicity in primary cortical neuron cultures as well as an inhibitory effect against LPS-induced TNF-alpha production in BV2 cells at a subnanomolar concentration.	Memantine	43-52	tumor necrosis factor	Mus musculus	234-243	
27983945-9	2016	Memantine significantly attenuated the body weight loss, colon weight, the plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and colon level of tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase (MPO); as well as macroscopic and microscopic signs of colitis.	Memantine	0-9	tumor necrosis factor	Mus musculus	163-190	
29042205-0	2018	Postnatal administration of memantine rescues TNF-alpha-induced decreased hippocampal precursor proliferation.	Memantine	28-37	tumor necrosis factor	Mus musculus	46-55	
27983945-9	2016	Memantine significantly attenuated the body weight loss, colon weight, the plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and colon level of tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase (MPO); as well as macroscopic and microscopic signs of colitis.	Memantine	0-9	tumor necrosis factor	Mus musculus	192-201	
24473380-9	2014	RESULTS: Memantine pretreatment improved the LPS-induced ALI lung tissue morphological changes, reduced their lung wet/dry ratio, the levels of TNF-alpha and LDH activity in BALF, and also reduced the MPO and MDA content in the lung tissue.	Memantine	9-18	tumor necrosis factor	Mus musculus	144-153