PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17188316-6 2007 Pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist memantine (18 mg/kg, sc), in combination with atropine sulfate (16 mg/kg, sc), significantly attenuated carbofuran-induced changes in AChE activity and levels of F(2)-IsoPs and F(4)-NeuroPs, declines in HEPs, as well as the alterations in morphology of hippocampal neurons. Memantine 70-79 acetylcholinesterase Rattus norvegicus 204-208 15033007-5 2004 The AChE activities both in blood and brain of memantine treated groups were not significantly different from those in dichlorvos alone group. Memantine 47-56 acetylcholinesterase Rattus norvegicus 4-8 15275830-6 2004 The results from the present study provide evidence that rivastigmine as a pseudo-irreversible (or slow-reversible) AChE inhibitor shares this property described for reversible inhibitors, since memantine (1-100 microM), irrespective of whether given prior to or after rivastigmine did not influence rivastigmine"s AChE inhibition in vitro. Memantine 195-204 acetylcholinesterase Rattus norvegicus 116-120 1475066-3 1992 Pretreatment with memantine HCl (MEM, 18 mg/kg, sc) together with atropine sulfate (ATS, 16 mg/kg, sc), 60 min and 15 min, respectively, prior to nerve agents attenuated AChE inhibition, prevented myonecrosis, and muscle fasciculations as well as other signs of cholinergic toxicity. Memantine 18-31 acetylcholinesterase Rattus norvegicus 170-174 30759264-8 2019 Vildagliptin alone and in combination with memantine caused a decrease in blood glucose, HOMA-IR, lipid profile, Hcy, malanodialdhyde, and acetylcholinesterase, and an increase in apolipoprotein E. Memantine 43-52 acetylcholinesterase Rattus norvegicus 139-159 2241428-9 1990 These results suggest that memantine may counteract the acute methyl parathion toxicity by (a) protection of acetylcholinesterase from inhibition, (b) rapid reactivation of inhibited acetylcholinesterase and (c) rapid bioelimination of methyl parathion, in addition to cholinolytic effects of atropine sulfate. Memantine 27-36 acetylcholinesterase Rattus norvegicus 109-129 2241428-9 1990 These results suggest that memantine may counteract the acute methyl parathion toxicity by (a) protection of acetylcholinesterase from inhibition, (b) rapid reactivation of inhibited acetylcholinesterase and (c) rapid bioelimination of methyl parathion, in addition to cholinolytic effects of atropine sulfate. Memantine 27-36 acetylcholinesterase Rattus norvegicus 183-203 2778846-5 1989 A single sc dose of memantine HCl (MEM, 18 mg/kg) and atropine sulfate (ATS, 16 mg/kg) 60 and 15 min, respectively, prior to carbofuran administration completely prevented the expected gross toxic signs and significantly (p less than .01) attenuated the carbofuran-induced inhibition of AChE activity. Memantine 20-33 acetylcholinesterase Rattus norvegicus 287-291 2778846-8 1989 The results of this study suggested that, in addition to cholinolytic effects of atropine, memantine may prevent and antagonize the acute toxicity of carbofuran by (a) protection of AChE activity and its rapid reactivation from inhibition and (b) rapid elimination of carbofuran. Memantine 91-100 acetylcholinesterase Rattus norvegicus 182-186 1733053-8 1992 Memantine reduced inhibition of AChE activity in crude brain homogenates by soman, but not by edrophonium (anionic site inhibitor) or decamethonium (peripheral site inhibitor). Memantine 0-9 acetylcholinesterase Rattus norvegicus 32-36 30682440-15 2019 Pretreatment with memantine assured higher AChE activity in brain and diaphragm than in unpretreated rats (46% vs 28% and 68% vs. 38%, respectively). Memantine 18-27 acetylcholinesterase Rattus norvegicus 43-47 30682440-20 2019 Mechanism of the antidotal effect of memantine against soman poisoning appears to be a combination of AChE-protecting and NMDA receptor-blocking action. Memantine 37-46 acetylcholinesterase Rattus norvegicus 102-106