PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2778846-5	1989	A single sc dose of memantine HCl (MEM, 18 mg/kg) and atropine sulfate (ATS, 16 mg/kg) 60 and 15 min, respectively, prior to carbofuran administration completely prevented the expected gross toxic signs and significantly (p less than .01) attenuated the carbofuran-induced inhibition of AChE activity.	Memantine	20-33	acetylcholinesterase	Rattus norvegicus	287-291	
17188316-6	2007	Pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist memantine (18 mg/kg, sc), in combination with atropine sulfate (16 mg/kg, sc), significantly attenuated carbofuran-induced changes in AChE activity and levels of F(2)-IsoPs and F(4)-NeuroPs, declines in HEPs, as well as the alterations in morphology of hippocampal neurons.	Memantine	70-79	acetylcholinesterase	Rattus norvegicus	204-208	
15275830-6	2004	The results from the present study provide evidence that rivastigmine as a pseudo-irreversible (or slow-reversible) AChE inhibitor shares this property described for reversible inhibitors, since memantine (1-100 microM), irrespective of whether given prior to or after rivastigmine did not influence rivastigmine"s AChE inhibition in vitro.	Memantine	195-204	acetylcholinesterase	Rattus norvegicus	116-120	
15033007-5	2004	The AChE activities both in blood and brain of memantine treated groups were not significantly different from those in dichlorvos alone group.	Memantine	47-56	acetylcholinesterase	Rattus norvegicus	4-8	
1475066-3	1992	Pretreatment with memantine HCl (MEM, 18 mg/kg, sc) together with atropine sulfate (ATS, 16 mg/kg, sc), 60 min and 15 min, respectively, prior to nerve agents attenuated AChE inhibition, prevented myonecrosis, and muscle fasciculations as well as other signs of cholinergic toxicity.	Memantine	18-31	acetylcholinesterase	Rattus norvegicus	170-174	
1733053-8	1992	Memantine reduced inhibition of AChE activity in crude brain homogenates by soman, but not by edrophonium (anionic site inhibitor) or decamethonium (peripheral site inhibitor).	Memantine	0-9	acetylcholinesterase	Rattus norvegicus	32-36	
2241428-9	1990	These results suggest that memantine may counteract the acute methyl parathion toxicity by (a) protection of acetylcholinesterase from inhibition, (b) rapid reactivation of inhibited acetylcholinesterase and (c) rapid bioelimination of methyl parathion, in addition to cholinolytic effects of atropine sulfate.	Memantine	27-36	acetylcholinesterase	Rattus norvegicus	109-129	
2241428-9	1990	These results suggest that memantine may counteract the acute methyl parathion toxicity by (a) protection of acetylcholinesterase from inhibition, (b) rapid reactivation of inhibited acetylcholinesterase and (c) rapid bioelimination of methyl parathion, in addition to cholinolytic effects of atropine sulfate.	Memantine	27-36	acetylcholinesterase	Rattus norvegicus	183-203	
2778846-8	1989	The results of this study suggested that, in addition to cholinolytic effects of atropine, memantine may prevent and antagonize the acute toxicity of carbofuran by (a) protection of AChE activity and its rapid reactivation from inhibition and (b) rapid elimination of carbofuran.	Memantine	91-100	acetylcholinesterase	Rattus norvegicus	182-186	
30759264-8	2019	Vildagliptin alone and in combination with memantine caused a decrease in blood glucose, HOMA-IR, lipid profile, Hcy, malanodialdhyde, and acetylcholinesterase, and an increase in apolipoprotein E.	Memantine	43-52	acetylcholinesterase	Rattus norvegicus	139-159	
30682440-15	2019	Pretreatment with memantine assured higher AChE activity in brain and diaphragm than in unpretreated rats (46% vs 28% and 68% vs. 38%, respectively).	Memantine	18-27	acetylcholinesterase	Rattus norvegicus	43-47	
30682440-20	2019	Mechanism of the antidotal effect of memantine against soman poisoning appears to be a combination of AChE-protecting and NMDA receptor-blocking action.	Memantine	37-46	acetylcholinesterase	Rattus norvegicus	102-106