PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32544502-5	2020	Moreover, in in vivo studies in rats, the protective effects of memantine on isoproterenol-induced myocardial infarction model (administration of 100 mg/kg isoproterenol subcutaneously for 2 consecutive days) was evaluated by measuring ECG pattern, mean arterial pressure, malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, cardiac tumor necrosis factor-alpha (TNF-alpha) level and cardiac remodeling.	Memantine	64-73	tumor necrosis factor	Rattus norvegicus	343-370	
34517281-10	2021	In addition, levels of neutrophil density, IL-1beta, IL-6, TNF-alpha, TLR4, NF-kappaB, MAPK and malondialdehyde decreased significantly in the Memantine-H group (P < 0.01).	Memantine	143-152	tumor necrosis factor	Rattus norvegicus	59-68	
32544502-5	2020	Moreover, in in vivo studies in rats, the protective effects of memantine on isoproterenol-induced myocardial infarction model (administration of 100 mg/kg isoproterenol subcutaneously for 2 consecutive days) was evaluated by measuring ECG pattern, mean arterial pressure, malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, cardiac tumor necrosis factor-alpha (TNF-alpha) level and cardiac remodeling.	Memantine	64-73	tumor necrosis factor	Rattus norvegicus	372-381	
32544502-8	2020	Memantine treatment reduced the expression of cardiac TNF-alpha in comparison to Iso group.	Memantine	0-9	tumor necrosis factor	Rattus norvegicus	54-63	
32020309-7	2020	RESULTS: ALZc3 and memantine improved memory impairment and antioxidant activity and reduced TNF-alpha expression, caspase-3 activity and Bax/Bcl-2 ratio in the rat"s hippocampus.	Memantine	19-28	tumor necrosis factor	Rattus norvegicus	93-102	
31495078-6	2019	Similarly, expression of the inflammatory cytokine genes TNFalpha and immediate-early gene ARC was significantly increased in the salicylate-treated cells, and decreased when the cells were treated with memantine.	Memantine	203-212	tumor necrosis factor	Rattus norvegicus	57-65	
28359852-12	2017	Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus.	Memantine	27-36	tumor necrosis factor	Rattus norvegicus	192-201	
30247872-7	2019	Furthermore, cells treated with acetate (6 mM) for 4 h had increased expression levels of TNFalpha relative to control, which was abolished by coapplication of memantine (10 muM).	Memantine	160-169	tumor necrosis factor	Rattus norvegicus	90-98	
30528722-5	2019	KEY FINDINGS: Memantine reduced ulcer index, reduced MDA, increased SOD, increased total nitrites and reduced expression of both TNF-alpha and NF-kappaB.	Memantine	14-23	tumor necrosis factor	Rattus norvegicus	129-138	
28359852-12	2017	Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus.	Memantine	71-80	tumor necrosis factor	Rattus norvegicus	192-201