PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23181523-7 2012 We then demonstrated the differential effect of memantine, an N-Methyl-D-aspartic acid (NMDA) subunit selective weak inhibitor, in early and late AD pathology, and show that inhibition of the NMDA receptor NR2C/NR2D subunits located on inhibitory interneurons compensates for the greater excitatory decline observed with pathology. Memantine 48-57 glutamate ionotropic receptor NMDA type subunit 2C Homo sapiens 206-210 31555132-9 2019 The IC50 value of memantine as an NMDA antagonist is in micromolar range; the lowest limit is 112 ng/ml (GluN2C), and this value was achieved only in three cases. Memantine 18-27 glutamate ionotropic receptor NMDA type subunit 2C Homo sapiens 105-111