PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30448465-0	2019	Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride.	Memantine	59-68	microtubule associated protein tau	Homo sapiens	31-34	
35246269-13	2022	Restoring NR2B physiological expression patterns with CK2 inhibition and inhibiting the function of excessive extrasynaptic NR2B with Memantine both mitigated tau accumulation in vitro.	Memantine	134-143	microtubule associated protein tau	Homo sapiens	159-162	
22212311-6	2011	Aside from NMDA receptor antagonism, numerous studies have reported that memantine can also affect dopamine receptors, block excessive calcium influx and production of reactive oxygen species (ROS) induced by Abeta oligomers, and inhibit the internal ribosome entry site (IRES), thus preventing the expression of the amyloid precursor and tau proteins which are considered as early indicators of Alzheimer"s.	Memantine	73-82	microtubule associated protein tau	Homo sapiens	339-342	
20839903-8	2010	After therapy with memantine, patients had a 27% decline in CSF tau levels (p = 0.04) and four patients whose CSF tau dropped to healthy control levels lost only -0.42 ALSFRS points per month.	Memantine	19-28	microtubule associated protein tau	Homo sapiens	64-67	
20839903-8	2010	After therapy with memantine, patients had a 27% decline in CSF tau levels (p = 0.04) and four patients whose CSF tau dropped to healthy control levels lost only -0.42 ALSFRS points per month.	Memantine	19-28	microtubule associated protein tau	Homo sapiens	114-117	
19661628-1	2009	Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro.	Memantine	29-38	microtubule associated protein tau	Homo sapiens	48-51	
18989117-8	2008	Memantine also holds promise to treat neuropsychiatric symptoms, but more prospective trials are needed.With better understanding of pathogenic molecular pathways involving microtubule-associated protein tau, progranulin and TDP-43, potential disease-modifying therapies are being studied in animal models and approaching human trials.	Memantine	0-9	microtubule associated protein tau	Homo sapiens	173-207	
17700020-0	2007	Reduction of phosphorylated tau during memantine treatment of Alzheimer"s disease.	Memantine	39-48	microtubule associated protein tau	Homo sapiens	28-31	
17700020-4	2007	It has been shown in vitro that memantine reverse induced abnormal hyperphosphorylation of tau in hippocampal neurons of rats.	Memantine	32-41	microtubule associated protein tau	Homo sapiens	91-94