PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35543645-7	2022	Additionally, memantine or C16 evidently inhibited apoptotic pathways by reducing the Bax and caspase-3, 8, 9 expressions and increasing Bcl-2 expression.	Memantine	14-23	BCL2, apoptosis regulator	Rattus norvegicus	137-142	
22824463-0	2012	Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid beta1-40.	Memantine	0-9	BCL2, apoptosis regulator	Rattus norvegicus	52-57	
32020309-7	2020	RESULTS: ALZc3 and memantine improved memory impairment and antioxidant activity and reduced TNF-alpha expression, caspase-3 activity and Bax/Bcl-2 ratio in the rat"s hippocampus.	Memantine	19-28	BCL2, apoptosis regulator	Rattus norvegicus	142-147	
22824463-7	2012	Injection of Abeta resulted in neurodegeneration, DNA fragmentation, increased Bcl-2 immunostaining, and significantly impaired performance in an active avoidance task, all which were significantly attenuated in rats treated with memantine.	Memantine	230-239	BCL2, apoptosis regulator	Rattus norvegicus	79-84	
24551770-8	2012	Also an increase in Bax/Bcl-2 ratio in rat hippocampus cells .Memantine pretreatment could not change the levels of Bax, Bcl-2, Caspase-3 significantly in rat"s hippocampus cells.	Memantine	62-71	BCL2, apoptosis regulator	Rattus norvegicus	24-29	
16107786-7	2006	Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation.	Memantine	0-9	BCL2, apoptosis regulator	Rattus norvegicus	41-46