PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34844267-0	2021	Favorable Response to "Memantine" in a Child with GRIN2B Epileptic Encephalopathy.	Memantine	23-32	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	50-56	
23421676-3	2013	To determine key binding interactions of memantine, we made side-by-side comparisons of IC(50) for memantine and amantadine, a structurally related drug, in the GluN1/GluN2B NMDA receptor.	Memantine	41-50	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	167-173	
23421676-4	2013	We identified hydrophobic binding pockets for the two methyl groups on memantine formed by the residues A645 and A644 on the third transmembrane helices of GluN1 and GluN2B, respectively.	Memantine	71-80	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	166-172	
22631440-8	2012	Interestingly, these effects were prevented by MK-801 and memantine, suggesting a role for extrasynaptic NMDARs in Abeta toxicity, and by ifenprodil, further indicating the involvement of GluN2B-containing NMDARs.	Memantine	58-67	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	188-194	
22142193-8	2012	Memantine (10 microM) and ifenprodil (10 microM), which preferentially inhibit GluN2B-containing NMDA receptors, protected from Tat-induced cell death with no effect on synapse loss.	Memantine	0-9	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	79-85	
11369029-11	2001	The up-regulations observed after memantine (cortex, NR2B: 172+/-17%; hippocampus, NR1-1/1-2: 156+/-8%) or MK-801 (cortex, NR2B: 174+/-22%; hippocampus, NR1-1/1-2: 140+/-3%) were almost identical.	Memantine	34-43	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	53-57	
35246269-13	2022	Restoring NR2B physiological expression patterns with CK2 inhibition and inhibiting the function of excessive extrasynaptic NR2B with Memantine both mitigated tau accumulation in vitro.	Memantine	134-143	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	124-128	
33970453-8	2021	Additionally, the NR2B antagonists memantine and Ro25-6981 reversed this neurotoxicity induced by propofol postconditioning.	Memantine	35-44	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	18-22	
24491052-5	2014	RESULTS: MTT assay showed gp120 produced dose-dependent neuronal injury when added to the culture media and the gp120-induced neuronal injury was blocked by memantine, a specific NR2B receptor antagonist.	Memantine	157-166	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	179-183