PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35559146-11 2022 Furthermore, the expressions of BDNF, Seladin 1, and Sirtuin 6 as neuroprotective target genes were modified after clavulanic acid and memantine administrations; similarly, the results obtained from clavulanic acid were more significant. Memantine 135-144 brain-derived neurotrophic factor Rattus norvegicus 32-36 23414063-0 2014 Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. Memantine 93-102 brain-derived neurotrophic factor Rattus norvegicus 0-33 23414063-2 2014 Memantine, a non-competitive antagonist of N-methyl-D-aspartate receptors, induces expression of BDNF in several brain regions including the striatum. Memantine 0-9 brain-derived neurotrophic factor Rattus norvegicus 97-101 23414063-6 2014 The possible role for BDNF in the memantine effect was tested by blockade of the TrkB receptor using the pharmacological agent K252a and by the BDNF scavenger TrkB-Fc. Memantine 34-43 brain-derived neurotrophic factor Rattus norvegicus 22-26 23414063-9 2014 In addition, we found that inhibition or blockade of the BDNF signalling pathway prevented the early, but not the delayed decrease in EtOH consumption induced by memantine. Memantine 162-171 brain-derived neurotrophic factor Rattus norvegicus 57-61 22205542-11 2012 Low-dose memantine also significantly potentiated serum and brain BDNF levels. Memantine 9-18 brain-derived neurotrophic factor Rattus norvegicus 66-70 22327556-0 2012 Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. Memantine 0-9 brain-derived neurotrophic factor Rattus norvegicus 87-91 22327556-6 2012 Memantine treatment reversed anhedonia and the increase of adrenal gland weight, normalized corticosterone levels and increased BDNF protein levels in the prefrontal cortex in stressed rats. Memantine 0-9 brain-derived neurotrophic factor Rattus norvegicus 128-132 19954760-5 2010 Brain-derived neurotrophic factor (BDNF) hippocampal levels were assessed in imipramine- and memantine-treated rats by ELISA sandwich assay. Memantine 93-102 brain-derived neurotrophic factor Rattus norvegicus 0-33 19954760-6 2010 Interesting enough, acute administration, but not chronic administration of memantine at higher dose (20 mg/kg) increased BDNF protein levels in the rat hippocampus (p < 0.05). Memantine 76-85 brain-derived neurotrophic factor Rattus norvegicus 122-126 11591126-0 2001 The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Memantine 26-35 brain-derived neurotrophic factor Rattus norvegicus 44-77 11591126-2 2001 We have examined the effect of memantine (ip 5-50 mg/kg; 4 h) on the expression of brain-derived neurotrophic factor (BDNF) and trkB receptor mRNAs in rat brain by in situ hybridization. Memantine 31-40 brain-derived neurotrophic factor Rattus norvegicus 83-116 11591126-2 2001 We have examined the effect of memantine (ip 5-50 mg/kg; 4 h) on the expression of brain-derived neurotrophic factor (BDNF) and trkB receptor mRNAs in rat brain by in situ hybridization. Memantine 31-40 brain-derived neurotrophic factor Rattus norvegicus 118-122 11591126-3 2001 Memantine at a clinically relevant dose markedly increased BDNF mRNA levels in the limbic cortex, and this effect was more widespread and pronounced at higher doses. Memantine 0-9 brain-derived neurotrophic factor Rattus norvegicus 59-63 11591126-4 2001 Effects of memantine on BDNF mRNA were also reflected in changes in BDNF protein levels. Memantine 11-20 brain-derived neurotrophic factor Rattus norvegicus 24-28 11591126-4 2001 Effects of memantine on BDNF mRNA were also reflected in changes in BDNF protein levels. Memantine 11-20 brain-derived neurotrophic factor Rattus norvegicus 68-72 11591126-5 2001 Moreover, memantine induced isoforms of the BDNF receptor trkB. Memantine 10-19 brain-derived neurotrophic factor Rattus norvegicus 44-48 11591126-6 2001 Taken together, these data suggest that the neuroprotective properties of memantine could be mediated by the increased endogenous production of BDNF in the brain. Memantine 74-83 brain-derived neurotrophic factor Rattus norvegicus 144-148 33290797-0 2021 Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression. Memantine 0-9 brain-derived neurotrophic factor Rattus norvegicus 156-160 33290797-9 2021 CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine. Memantine 191-200 brain-derived neurotrophic factor Rattus norvegicus 112-145 33290797-9 2021 CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine. Memantine 191-200 brain-derived neurotrophic factor Rattus norvegicus 147-151 33290797-11 2021 Thus, Memantine treatment exerts an antidepressant-like effect by preventing CUS induced excitotoxicity, oxidative stress, and enhancing CUS induced decrease in mitochondrial functioning and expression of cell survival genes via upregulation of stress-responsive CREB/BDNF signaling. Memantine 6-15 brain-derived neurotrophic factor Rattus norvegicus 268-272 30233298-0 2018 Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus. Memantine 91-100 brain-derived neurotrophic factor Rattus norvegicus 115-119 30233298-9 2018 However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus. Memantine 60-69 brain-derived neurotrophic factor Rattus norvegicus 118-122 29680698-0 2018 Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress. Memantine 17-26 brain-derived neurotrophic factor Rattus norvegicus 97-101 29680698-9 2018 Administration of memantine reversed depression-like behavior and memory impairment and significantly increased BDNF and TrkB mRNA levels in both prefrontal cortex and hippocampus of stress exposed rats. Memantine 18-27 brain-derived neurotrophic factor Rattus norvegicus 112-116 29680698-11 2018 Our results also suggest that upregulated mRNA levels of BDNF and TrkB in the brain might be essential for antidepressant-like activity of memantine in stress exposed rats. Memantine 139-148 brain-derived neurotrophic factor Rattus norvegicus 57-61 27825855-0 2017 Effect of co-administration of memantine and sertraline on the antidepressant-like activity and brain-derived neurotrophic factor (BDNF) levels in the rat brain. Memantine 31-40 brain-derived neurotrophic factor Rattus norvegicus 96-129 27825855-7 2017 Combined treatment with memantine and sertraline produced stronger increases in the BDNF protein levels in the hippocampus and prefrontal cortex. Memantine 24-33 brain-derived neurotrophic factor Rattus norvegicus 84-88 27825855-9 2017 Antidepressant properties using the combination of memantine and sertraline could be attributed to increased levels of BDNF. Memantine 51-60 brain-derived neurotrophic factor Rattus norvegicus 119-123 25680935-9 2015 Our results revealed that Memantine improved spatial working memory in repeated stress, decreased serum level of stress markers and modified the hippocampal synaptic plasticity markers in both patterns of stress exposure; in ARS, Memantine upregulated the expression of synaptophysin and brain-derived neurotrophic factor and downregulated the expression of calcium-/calmodulin-dependent protein kinase II, and in repeated restraint stress, it upregulated the expression of synaptophysin and downregulated calcium-/calmodulin-dependent protein kinase II expression. Memantine 26-35 brain-derived neurotrophic factor Rattus norvegicus 288-321 25680935-9 2015 Our results revealed that Memantine improved spatial working memory in repeated stress, decreased serum level of stress markers and modified the hippocampal synaptic plasticity markers in both patterns of stress exposure; in ARS, Memantine upregulated the expression of synaptophysin and brain-derived neurotrophic factor and downregulated the expression of calcium-/calmodulin-dependent protein kinase II, and in repeated restraint stress, it upregulated the expression of synaptophysin and downregulated calcium-/calmodulin-dependent protein kinase II expression. Memantine 230-239 brain-derived neurotrophic factor Rattus norvegicus 288-321