PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23021418-3 2013 STZ also significantly altered NMDA subunits, NR2A and NR2B protein and mRNA expression which were restored by Memantine only. Memantine 111-120 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 55-59 31495078-5 2019 NR2B was significantly upregulated in salicylate-treated cells, but downregulated after memantine treatment. Memantine 88-97 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 0-4 31495078-10 2019 Additionally, NR2B protein expression in the auditory cortex was markedly increased in the salicylate-treated group, whereas it was reduced in the memantine-treated group. Memantine 147-156 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 14-18 23810967-3 2013 Here memantine is administered in animals before or after spinal nerve ligation (SNL) in order to evaluate the induced antinociceptive/cognitive effects and associated molecular events, including the phosphorylation of several tyrosine (pTyr(1336), pTyr(1472)) and serine (pSer(1303)) residues in the NR2B subunit of the NMDA receptor. Memantine 5-14 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 301-305 31834143-9 2020 Memantine treatment can prevent okadaic acid induced impairment of hippocampal-dependent spatial memory and accompanied by modulation of the expression level of alpha7 subunit of nACh and NR2B subunit of NMDA receptors in the hippocampus. Memantine 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 188-192 31495078-0 2019 Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat. Memantine 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 70-74 30233298-9 2018 However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus. Memantine 60-69 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 110-116 29382619-1 2018 BACKGROUND: The main aim of this study is to elucidate whether the neuroprotective effect of memantine, a noncompetitive N-methyl-d-aspartate receptor 2B (NR2B) antagonist, affects neuronal nitrosative stress, apoptosis, and NR2B expression and improves functional outcomes. Memantine 93-102 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 121-153 29382619-1 2018 BACKGROUND: The main aim of this study is to elucidate whether the neuroprotective effect of memantine, a noncompetitive N-methyl-d-aspartate receptor 2B (NR2B) antagonist, affects neuronal nitrosative stress, apoptosis, and NR2B expression and improves functional outcomes. Memantine 93-102 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 155-159 29382619-1 2018 BACKGROUND: The main aim of this study is to elucidate whether the neuroprotective effect of memantine, a noncompetitive N-methyl-d-aspartate receptor 2B (NR2B) antagonist, affects neuronal nitrosative stress, apoptosis, and NR2B expression and improves functional outcomes. Memantine 93-102 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 225-229 29382619-10 2018 CONCLUSIONS: Intraperitoneal injection of memantine in the acute stage may ameliorate TBI in rats by affecting NR2B expression and decreasing neuronal apoptosis and nitrosative stress in the injured cortex. Memantine 42-51 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 111-115 24486947-13 2014 Finally, loss of the anti-dyskinetic effect of memantine was associated to increased synaptic GluN2A/GluN2B ratio at striatal synaptic membranes. Memantine 47-56 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 101-107 23532860-8 2013 A similar potentiation was also observed when memantine was replaced with ifenprodil, suggesting a possible involvement of the NR2B subunit of the NMDA receptor. Memantine 46-55 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 127-131 17267580-13 2007 These results indicate that NR2B-containing NMDA receptors are key mediators of SD, and as such, memantine- and NR2B-selective antagonists may be useful new therapeutic agents for the treatment of migraine and other SD-related disorders (e.g., stroke and brain injury). Memantine 97-106 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 28-32 21440043-12 2011 In conclusion, memantine in dose of 20 mg/kg improves the sucrose consumption, reversal learning and prefrontal cortical synaptic plasticity, but impairs spatial memory, which is probably due to different extent of up-regulating NR2B receptor expression in prefrontal cortex and hippocampus in stressed rats. Memantine 15-24 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 229-233 16009352-5 2005 Coincubation with memantine (10 microM) completely blocked the ethanol-induced up-regulation of NR1 (102 +/- 4%), NR2A (95 +/- 7%) and NR2B (105 +/- 13%). Memantine 18-27 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 135-139 15452358-8 2005 In contrast, intrathecal injection of a non-selective NMDA antagonist, memantine, significantly inhibited CCI-induced mechanical allodynia at a dose of 300 nmol, indicating the difference in the site of action between the non-selective NMDA antagonist and the NR2B-specific NMDA antagonist. Memantine 71-80 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 260-264