PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28264232-6 2017 Memantine increased the autophagic-related proteins as the conversion ratio of light chain protein 3-II (LC3-II)-/LC3-I and the expression of beclin-1. Memantine 0-9 beclin 1 Homo sapiens 142-150 26459718-8 2015 Further experiments revealed that memantine was able to upregulate the expression of signaling molecules phosphorylated (p)-phosphoinositide 3-kinase, p-Akt and p-mammalian target of rapamycin (mTOR), and also inhibited the phosphorylation of the B-cell lymphoma 2/Beclin-1 complex via mitogen-activated protein kinase 8. Memantine 34-43 beclin 1 Homo sapiens 265-273