PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35235756-9	2022	Moreover, the terminal deoxynucleotidyl Transferase-mediated dUTP nick end labeling (TUNEL) apoptosis assay revealed that Memantine protected oxaliplatin-induced apoptosis through mitigating the ratio of Bax/Bcl-2 and Caspase-3 cleavage.	Memantine	122-131	caspase 3	Homo sapiens	218-227	
19959636-6	2010	RESULTS: At 30-microM concentrations, the genistein, resveratrol, and memantine inhibitors were able to reverse significantly the loss of cell viability, the activation of caspase-3/7 and caspase-9, and the production of ROS/RNS in ARPE-19 cell cultures.	Memantine	70-79	caspase 3	Homo sapiens	172-181	
19103181-8	2009	In this study, the association of 10 mg/kg memantine with 10 mg/kg galantamine increased the number of living pyramidal neurons, reduced TUNEL, active caspase-3 and SOD-2 immunoreactivity, and preserved spatial memory after ischemia-reperfusion injury; however, the effects of the combination were not statistically different from those observed in animals treated with galantamine alone.	Memantine	43-52	caspase 3	Homo sapiens	151-160	
18434534-0	2008	Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.	Memantine	99-108	caspase 3	Homo sapiens	19-28	
18434534-8	2008	Memantine (4 microM) inhibited isoflurane-induced elevations in cytosolic calcium levels and attenuated isoflurane-induced caspase-3 activation, apoptosis, and cell viability.	Memantine	0-9	caspase 3	Homo sapiens	123-132	
18434534-12	2008	We also show for the first time that the NMDA receptor partial antagonist, memantine, can prevent isoflurane-induced caspase-3 activation and apoptosis in vivo and in vitro.	Memantine	75-84	caspase 3	Homo sapiens	117-126	
17996985-4	2008	Memantine (0.1-2 microM) attenuated staurosporine-induced apoptosis as evidenced by reversal of the changes in mitochondrial membrane potential (DeltaPsi(m)) and decreased caspase-3 activity, lactate dehydrogenase (LDH) release and DNA fragmentation.	Memantine	0-9	caspase 3	Homo sapiens	172-181	
17996985-6	2008	Memantine at low micromolar concentrations also attenuated salsolinol- and doxorubicin-induced LDH release and DNA fragmentation, but only in the case of salsolinol was this effect accompanied by a decrease in caspase-3 activity.	Memantine	0-9	caspase 3	Homo sapiens	210-219	
28730337-0	2017	Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.	Memantine	0-9	caspase 3	Homo sapiens	37-46	
28730337-14	2017	Memantine treatment reduced the ethanol-induced increase of intracellular calcium, caspase-3 activation, apoptosis, and the ethanol-induced decrease in cell viability.	Memantine	0-9	caspase 3	Homo sapiens	83-92	
28730337-15	2017	Our results indicate that ethanol-induced caspase-3 activation and apoptosis are likely to be dependent on cytosolic calcium levels and that they can be reduced by memantine treatment.	Memantine	164-173	caspase 3	Homo sapiens	42-51