PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16107786-7	2006	Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation.	Memantine	0-9	caspase 3	Rattus norvegicus	79-88	
24166606-12	2013	Taken together, the results obtained in this study seem to confirm the neuroprotective effect of memantine on increasing levels of cells with active caspase-3 and active caspase-9.	Memantine	97-106	caspase 3	Rattus norvegicus	149-158	
35543645-7	2022	Additionally, memantine or C16 evidently inhibited apoptotic pathways by reducing the Bax and caspase-3, 8, 9 expressions and increasing Bcl-2 expression.	Memantine	14-23	caspase 3	Rattus norvegicus	94-103	
32020309-7	2020	RESULTS: ALZc3 and memantine improved memory impairment and antioxidant activity and reduced TNF-alpha expression, caspase-3 activity and Bax/Bcl-2 ratio in the rat"s hippocampus.	Memantine	19-28	caspase 3	Rattus norvegicus	115-124	
33026572-7	2021	We have also found that both Memantine (5 microM) and Ibuprofen (200 muM) significantly prevented the STZ-induced change in CaMKIIalpha, CREB, Calpain, and Caspase 3 expressions in C6 astrocytoma cells.	Memantine	29-38	caspase 3	Rattus norvegicus	156-165	
28069373-0	2017	Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke.	Memantine	0-9	caspase 3	Rattus norvegicus	63-72	
28069373-9	2017	Moreover, memantine markedly suppressed the activation of the calpain-caspase-3 pathway and cell apoptosis, and consequently, attenuated brain damage and neuronal loss in MCAO rats.	Memantine	10-19	caspase 3	Rattus norvegicus	70-79