PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32020309-7 2020 RESULTS: ALZc3 and memantine improved memory impairment and antioxidant activity and reduced TNF-alpha expression, caspase-3 activity and Bax/Bcl-2 ratio in the rat"s hippocampus. Memantine 19-28 caspase 3 Rattus norvegicus 115-124 33026572-7 2021 We have also found that both Memantine (5 microM) and Ibuprofen (200 muM) significantly prevented the STZ-induced change in CaMKIIalpha, CREB, Calpain, and Caspase 3 expressions in C6 astrocytoma cells. Memantine 29-38 caspase 3 Rattus norvegicus 156-165 35543645-7 2022 Additionally, memantine or C16 evidently inhibited apoptotic pathways by reducing the Bax and caspase-3, 8, 9 expressions and increasing Bcl-2 expression. Memantine 14-23 caspase 3 Rattus norvegicus 94-103 28069373-0 2017 Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke. Memantine 0-9 caspase 3 Rattus norvegicus 63-72 28069373-9 2017 Moreover, memantine markedly suppressed the activation of the calpain-caspase-3 pathway and cell apoptosis, and consequently, attenuated brain damage and neuronal loss in MCAO rats. Memantine 10-19 caspase 3 Rattus norvegicus 70-79 24166606-12 2013 Taken together, the results obtained in this study seem to confirm the neuroprotective effect of memantine on increasing levels of cells with active caspase-3 and active caspase-9. Memantine 97-106 caspase 3 Rattus norvegicus 149-158 16107786-7 2006 Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation. Memantine 0-9 caspase 3 Rattus norvegicus 79-88