PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30244611-0 2018 An evaluation of memantine ER + donepezil for the treatment of Alzheimer"s disease. Memantine 17-26 epiregulin Homo sapiens 27-29 30244611-6 2018 Namzaric , a fixed dose combination of donepezil and memantine extended-release (ER) (FDC memantine ER/donepezil), was recently approved by the U.S. Food and Drug Administration (FDA) for patients with moderate to severe AD and warrants further consideration as a clinically useful and advantageous pharmacotherapy in AD. Memantine 53-62 epiregulin Homo sapiens 81-83 30244611-6 2018 Namzaric , a fixed dose combination of donepezil and memantine extended-release (ER) (FDC memantine ER/donepezil), was recently approved by the U.S. Food and Drug Administration (FDA) for patients with moderate to severe AD and warrants further consideration as a clinically useful and advantageous pharmacotherapy in AD. Memantine 90-99 epiregulin Homo sapiens 81-83 30244611-7 2018 Areas covered: This review discusses the pharmacological properties, efficacy, and safety/tolerability data of this FDC memantine ER/donepezil as well as its benefits and disadvantages for patients and families. Memantine 120-129 epiregulin Homo sapiens 130-132 30244611-9 2018 Expert opinion: Aside from its cost, FDC memantine ER/donepezil improves adherence to medication and reduces caregiver burden. Memantine 41-50 epiregulin Homo sapiens 51-53 26519339-0 2015 Memantine ER/Donepezil: A Review in Alzheimer"s Disease. Memantine 0-9 epiregulin Homo sapiens 10-12 26519339-1 2015 A once-daily, fixed-dose combination of memantine extended-release (ER)/donepezil 28/10 mg (Namzaric ) is available in the USA for patients with moderate to severe Alzheimer"s disease (AD) on stable memantine and donepezil therapy. Memantine 40-49 epiregulin Homo sapiens 68-70 26519339-3 2015 In a 24-week, phase III trial in patients with moderate to severe AD, addition of memantine ER 28 mg once daily to stable cholinesterase inhibitor (ChEI) therapy was more effective than add-on placebo on measures of cognition, global clinical status, dementia behaviour and semantic processing ability, although between-group differences on a measure of daily function did not significantly differ. Memantine 82-91 epiregulin Homo sapiens 92-94 26519339-4 2015 In subgroup analyses in donepezil-treated patients, add-on memantine ER was more effective than add-on placebo on measures of cognition, dementia behaviour and semantic processing, although there were no significant between-group differences on measures of global clinical status and daily function. Memantine 59-68 epiregulin Homo sapiens 69-71 26519339-5 2015 Memantine ER plus ChEI combination therapy was generally well tolerated in the phase III trial, with diarrhoea, dizziness and influenza occurring at least twice as often with add-on memantine ER as add-on placebo in donepezil-treated patients. Memantine 0-9 epiregulin Homo sapiens 10-12 26519339-6 2015 Thus, memantine ER plus donepezil combination therapy is an effective and well tolerated treatment option for patients with moderate to severe AD. Memantine 6-15 epiregulin Homo sapiens 16-18 20540654-0 2010 Memantine ER, a once-daily formulation for the treatment of Alzheimer"s disease. Memantine 0-9 epiregulin Homo sapiens 10-12 25899711-3 2015 The memantine extended-release (ER) (Namenda XR( )) 28 mg once-daily capsule formulation was approved in the USA in 2010 and became available more recently. Memantine 4-13 epiregulin Homo sapiens 32-34 25899711-3 2015 The memantine extended-release (ER) (Namenda XR( )) 28 mg once-daily capsule formulation was approved in the USA in 2010 and became available more recently. Memantine 37-47 epiregulin Homo sapiens 32-34 25899711-4 2015 The potential advantages of memantine ER over the IR formulation include a more convenient dosage regimen and lower pill burden that may improve adherence to therapy; also, memantine ER capsules may be opened and the contents sprinkled on applesauce for patients who have difficulty swallowing. Memantine 173-182 epiregulin Homo sapiens 38-40 25899711-4 2015 The potential advantages of memantine ER over the IR formulation include a more convenient dosage regimen and lower pill burden that may improve adherence to therapy; also, memantine ER capsules may be opened and the contents sprinkled on applesauce for patients who have difficulty swallowing. Memantine 173-182 epiregulin Homo sapiens 183-185 25899711-5 2015 Memantine ER provides a higher total daily dosage than the recommended memantine IR regimen and pharmacokinetic data indicate greater exposure with the ER formulation, but the clinical implications of this are unclear, as the two formulations have not been assessed in a comparative clinical trial. Memantine 0-9 epiregulin Homo sapiens 10-12 25899711-6 2015 The efficacy of memantine ER 28 mg once daily was demonstrated in a large, multinational, phase III trial, which showed that the addition of memantine ER to ongoing oral cholinesterase inhibitors improved key outcomes compared with cholinesterase inhibitor monotherapy, including measures of cognition and global status, which were the co-primary endpoints of the study. Memantine 16-25 epiregulin Homo sapiens 26-28 25899711-6 2015 The efficacy of memantine ER 28 mg once daily was demonstrated in a large, multinational, phase III trial, which showed that the addition of memantine ER to ongoing oral cholinesterase inhibitors improved key outcomes compared with cholinesterase inhibitor monotherapy, including measures of cognition and global status, which were the co-primary endpoints of the study. Memantine 16-25 epiregulin Homo sapiens 151-153 25899711-6 2015 The efficacy of memantine ER 28 mg once daily was demonstrated in a large, multinational, phase III trial, which showed that the addition of memantine ER to ongoing oral cholinesterase inhibitors improved key outcomes compared with cholinesterase inhibitor monotherapy, including measures of cognition and global status, which were the co-primary endpoints of the study. Memantine 141-150 epiregulin Homo sapiens 26-28 20540654-5 2010 AREAS COVERED IN THIS REVIEW: The goal of this article is to review the once-daily memantine ER 28 mg formulation for the treatment of Alzheimer"s disease, which, by simplifying the dosage regimen, decreases the problems of medication adherence. Memantine 83-92 epiregulin Homo sapiens 9-11