PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32048627-8 2019 Inhibitor concentration 50 (IC50) values calculated for atorvastatin and simvastatin were determined as 94 and 38 muM, respectively. Simvastatin 73-84 latexin Homo sapiens 114-117 32153409-6 2020 By whole-cell patch clamp, simvastatin (10 muM) remarkably inhibited the current intensity of Kv1.3, but had no effect on KCa3.1. Simvastatin 27-38 latexin Homo sapiens 43-46 32153409-7 2020 Simvastatin (10 muM) treatment significantly reduced the monocyte chemoattractant protein 1 (MCP-1)-induced monocyte migration. Simvastatin 0-11 latexin Homo sapiens 16-19 32048627-10 2019 When six concentrations of bortezomib used in the study were combined with 12.5 muM inactive concentrations of statins that did not cause inhibition in cell proliferation, both atorvastatin and simvastatin increased the effect of bortezomib at all the concentrations used, and simvastatin showed a stronger efficacy than atorvastatin. Simvastatin 194-205 latexin Homo sapiens 80-83 27207105-9 2016 Simvastatin was the most potent inhibitor of sFlt-1 secretion from endothelial cells (IC 50 3.2 muM), trophoblast cells (IC 50 61.4 muM) and placental explants. Simvastatin 0-11 latexin Homo sapiens 96-99 30220377-7 2018 Simvastatin (1 muM) reduced effect of TGF-beta1 (5 ng/mL) on hVF proliferation, myofibroblast differentiation (reduced alpha-smooth muscle actin [alpha-SMA-expression]) and activation (decreased procollagen-peptide release). Simvastatin 0-11 latexin Homo sapiens 15-18 30729760-4 2019 MATERIAL AND METHODS: Three-dimensional cell spheroids were fabricated using concave silicon elastomerbased microwells in the presence of simvastatin at concentrations of 1 muM and 10 muM. Simvastatin 138-149 latexin Homo sapiens 184-187 27207105-9 2016 Simvastatin was the most potent inhibitor of sFlt-1 secretion from endothelial cells (IC 50 3.2 muM), trophoblast cells (IC 50 61.4 muM) and placental explants. Simvastatin 0-11 latexin Homo sapiens 132-135 26756263-8 2016 RESULTS: H1975 cells showed significantly reduced viability compared with HCC827 cells after treatment with simvastatin (2 muM) for 48 hours. Simvastatin 108-119 latexin Homo sapiens 123-126 26966430-6 2016 The IC50 values of simvastatin alone and irinotecan alone were 115.4 +- 0.14 muM (r = 0.98) and 62.5 +- 0.18 muM (r = 0.98) in HT-29 cells without resistance to irinotecan. Simvastatin 19-30 latexin Homo sapiens 77-80 26966430-6 2016 The IC50 values of simvastatin alone and irinotecan alone were 115.4 +- 0.14 muM (r = 0.98) and 62.5 +- 0.18 muM (r = 0.98) in HT-29 cells without resistance to irinotecan. Simvastatin 19-30 latexin Homo sapiens 109-112 24855121-5 2014 RESULTS: Exposure to 5 muM simvastatin significantly increased the tuberculocidal activity of isoniazid in J774 macrophages at Day 3 after infection versus isoniazid alone (P=0.02). Simvastatin 27-38 latexin Homo sapiens 23-26 24112098-11 2014 After the administration of 0.1 muM simvastatin, the expression of ALP, bone sialoprotein, and bone morphogenetic protein-2 genes were significantly upregulated, and the ALP activity and mineralized nodule formation were significantly higher in the simvastatin-treated cells than the control cells. Simvastatin 36-47 latexin Homo sapiens 32-35 24112098-11 2014 After the administration of 0.1 muM simvastatin, the expression of ALP, bone sialoprotein, and bone morphogenetic protein-2 genes were significantly upregulated, and the ALP activity and mineralized nodule formation were significantly higher in the simvastatin-treated cells than the control cells. Simvastatin 249-260 latexin Homo sapiens 32-35 25840272-7 2015 Simvastatin induced dose-dependent apoptosis in leiomyoma cells as measured by a fluorometric caspase-3 activity assay, and inhibited proliferation as demonstrated by an (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay (both were significant at 5 and 10 muM). Simvastatin 0-11 latexin Homo sapiens 274-277 24419251-5 2014 RESULTS: The IL-17A, IL-6, IL-22 and IFN-gamma were significantly reduced in a dose response after simvastatin treatment (50 muM, p = 0.0005; p < 0.0001; p < 0.02; p = 0.0005, respectively). Simvastatin 99-110 latexin Homo sapiens 125-128 24419251-6 2014 The IL-17A and IL-6 cytokines were also significantly reduced in lower concentrations of simvastatin (10 muM) compared to controls (p = 0.018; p = 0.04) and compared to the standard drug (p = 0.007; p = 0.0001). Simvastatin 89-100 latexin Homo sapiens 105-108 23961716-5 2013 METHODS: Human embryonic kidney cells HEK-293T and human pancreatic cancer cells MiaPaCa-2 were treated with simvastatin (6 and 12 muM) for 24 and 48 hours respectively. Simvastatin 109-120 latexin Homo sapiens 131-134 24028293-3 2014 Western blotting of human pulmonary artery ECs treated with simvastatin (5 muM) confirmed a significant time-dependent increase (16-48 h) in claudin-5 protein expression compared with controls, without detectable alterations in zonula occludens-1 or occludin. Simvastatin 60-71 latexin Homo sapiens 75-78 20803306-6 2011 After 96 h the 50% inhibition concentration (IC(50)) of SMV in MTT assays for two more sensitive meningioma cell lines (one benign and one malignant) was below 0.9 muM, while the IC(50) was 2.8 muM or higher for two other meningioma lines. Simvastatin 56-59 latexin Homo sapiens 164-167 20803306-6 2011 After 96 h the 50% inhibition concentration (IC(50)) of SMV in MTT assays for two more sensitive meningioma cell lines (one benign and one malignant) was below 0.9 muM, while the IC(50) was 2.8 muM or higher for two other meningioma lines. Simvastatin 56-59 latexin Homo sapiens 194-197 20803306-10 2011 Addition of 40 muM PGZ significantly decreased the fraction of clonogenic cells in soft-agar assays, as compared with 2.8 muM SMV alone. Simvastatin 126-129 latexin Homo sapiens 15-18 20810539-6 2010 The activity in human liver microsomes was also strongly inhibited by simvastatin and troglitazone (K(i) = 0.8 +- 0.1 and 5.6 +- 0.2 muM, respectively). Simvastatin 70-81 latexin Homo sapiens 133-136 20737288-5 2011 At higher simvastatin concentration (10 muM), a synergistic increase in eNOS and TM mRNA expression was observed. Simvastatin 10-21 latexin Homo sapiens 40-43 20737288-7 2011 A higher simvastatin concentration of 10 muM overcame the inhibitory effect of oscillating flow. Simvastatin 9-20 latexin Homo sapiens 41-44 20870034-4 2010 In isolated PA, KMUP-1 and simvastatin (0.1-100 muM) inhibited 5-HT (10 muM)-induced PA constriction. Simvastatin 27-38 latexin Homo sapiens 48-51 20870034-4 2010 In isolated PA, KMUP-1 and simvastatin (0.1-100 muM) inhibited 5-HT (10 muM)-induced PA constriction. Simvastatin 27-38 latexin Homo sapiens 72-75 20870034-6 2010 In pulmonary arterial smooth muscle cells (PASMCs), KMUP-1 (1-100 muM) and simvastatin (10 muM) inhibited 5-HT-induced cell migration and proliferation and KMUP-1 (1-100 muM) inhibited 5-HT-induced Ca2+ influx. Simvastatin 75-86 latexin Homo sapiens 91-94 20870034-6 2010 In pulmonary arterial smooth muscle cells (PASMCs), KMUP-1 (1-100 muM) and simvastatin (10 muM) inhibited 5-HT-induced cell migration and proliferation and KMUP-1 (1-100 muM) inhibited 5-HT-induced Ca2+ influx. Simvastatin 75-86 latexin Homo sapiens 91-94 20870034-7 2010 Similar to Y27632, KMUP-1 (1-100 muM) inhibited 5-HT-induced RhoA/ROCK expression, while KMUP-1, Y27632 and simvastatin at 10 muM inhibited 5-HT-induced 5-HTT expression and KMUP-1 inhibited 5-HT-induced phosphorylation of AKT and ERK1/2 in PASMCs. Simvastatin 108-119 latexin Homo sapiens 126-129 22049271-7 2010 The results indicated that simvastatin in low concentration (0.25 muM) seems to be growth stimulator although cell viability was reduced in concentrations of >=2 muM. Simvastatin 27-38 latexin Homo sapiens 66-69 22049271-7 2010 The results indicated that simvastatin in low concentration (0.25 muM) seems to be growth stimulator although cell viability was reduced in concentrations of >=2 muM. Simvastatin 27-38 latexin Homo sapiens 165-168 17251484-6 2007 RESULTS: Retinal arterioles dilated dose dependently to simvastatin (1 nM to 10 muM). Simvastatin 56-67 latexin Homo sapiens 80-83 17075836-3 2006 METHODS: Rheumatoid synoviocytes obtained from patients with active rheumatoid arthritis were stimulated with TNFalpha and incubated with simvastatin (SMV) (1 muM). Simvastatin 138-149 latexin Homo sapiens 159-162