PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26670440-0	2015	Protective effect of simvastatin on impaired intestine tight junction protein ZO-1 in a mouse model of Parkinson"s disease.	Simvastatin	21-32	tight junction protein 1	Mus musculus	78-82	
26670440-4	2015	In this study, the protective effect of simvastatin on ZO-1 was investigated using an MPTP mouse model of PD.	Simvastatin	40-51	tight junction protein 1	Mus musculus	55-59	
26670440-9	2015	Treatment with simvastatin could partly reverse the MPTP-induced changes in ZO-1 expression and reduce MMP-9 protein and activity.	Simvastatin	15-26	tight junction protein 1	Mus musculus	76-80	
26670440-10	2015	Taken together, these findings suggest that simvastatin administration may partially reverse the impairment of ZO-1 induced by MPTP via inhibiting the activity of MMP9, fortify the impaired intestinal barrier and limit gut-derived toxins that pass across the intestinal barrier.	Simvastatin	44-55	tight junction protein 1	Mus musculus	111-115	
24244596-10	2013	Simvastatin prevented high glucose or hyperglycemia-induced dysregulation of occludin and ZO-1 by inhibition of RhoA/ROCK1 signaling in cultured GEnCs and in db/db mice with early-stage DN.	Simvastatin	0-11	tight junction protein 1	Mus musculus	90-94	
24244596-11	2013	CONCLUSION: Our results indicate that activation of RhoA/ROCK1 by high glucose disrupts the expression and translocation of occludin/ZO-1 and that simvastatin alleviates occludin/ZO-1 dysregulation and albuminuria by suppressing RhoA/ROCK1 signaling during early-stage DN.	Simvastatin	147-158	tight junction protein 1	Mus musculus	179-183	
31585890-4	2020	The results showed that simvastatin, a clinically and widely used statin, prevented free fatty acid-induced endothelial hyperpermeability and disruption of ZO-1 and VE-cadherin junctions in mouse microvascular endothelial cells (MVECs).	Simvastatin	24-35	tight junction protein 1	Mus musculus	156-160