PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20512931-1	2010	We previously identified the marked upregulation of integrin beta4 in human lung endothelial cells (EC) treated with simvastatin, an HMG coA-reductase inhibitor with vascular-protective and anti-inflammatory properties in murine models of acute lung injury (ALI).	Simvastatin	117-128	integrin subunit beta 4	Homo sapiens	52-66	
26572585-1	2015	Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin beta4 (ITGB4) tyrosine phosphorylation.	Simvastatin	0-11	integrin subunit beta 4	Homo sapiens	133-147	
26572585-1	2015	Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin beta4 (ITGB4) tyrosine phosphorylation.	Simvastatin	0-11	integrin subunit beta 4	Homo sapiens	149-154	
22683568-5	2012	We initially confirmed a time- and dose-dependent effect of simvastatin on increased integrin-beta4 mRNA expression in human lung EC with peak protein expression evident at 16 h. Subsequently, reciprocal immunoprecipitation demonstrated an attenuation of LPS-induced integrin-beta4 tyrosine phosphorylation by simvastatin (5 muM, 16 h).	Simvastatin	60-71	integrin subunit beta 4	Homo sapiens	85-99	
22683568-5	2012	We initially confirmed a time- and dose-dependent effect of simvastatin on increased integrin-beta4 mRNA expression in human lung EC with peak protein expression evident at 16 h. Subsequently, reciprocal immunoprecipitation demonstrated an attenuation of LPS-induced integrin-beta4 tyrosine phosphorylation by simvastatin (5 muM, 16 h).	Simvastatin	310-321	integrin subunit beta 4	Homo sapiens	85-99	
22683568-8	2012	These findings support integrin-beta4 as an important mediator of ALI protection by simvastatin and implicate signaling by integrin-beta4 as a novel therapeutic target in patients with ALI.	Simvastatin	84-95	integrin subunit beta 4	Homo sapiens	23-37	
35250607-1	2022	We previously reported integrin beta 4 (ITGB4) is an important mediator of lung vascular protection by simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitor.	Simvastatin	103-114	integrin subunit beta 4	Homo sapiens	23-38	
35250607-1	2022	We previously reported integrin beta 4 (ITGB4) is an important mediator of lung vascular protection by simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitor.	Simvastatin	103-114	integrin subunit beta 4	Homo sapiens	40-45	
35250607-2	2022	In this study, we report increased endothelial cell (EC) expression specifically of ITGB4E, an ITGB4 mRNA splice variant, by simvastatin with effects on EC protein expression and inflammatory responses.	Simvastatin	125-136	integrin subunit beta 4	Homo sapiens	95-100