PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27743890-9	2016	Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4.	Simvastatin	0-11	insulin receptor	Homo sapiens	46-62	
34111424-7	2021	Simvastatin impaired the phosphorylation of the insulin receptor (IR beta), Akt ser473 and S6rp, and increased phosphorylation of AMPK thr172 in both myotubes and myoblasts, which was prevented by insulin and mevalonate.	Simvastatin	0-11	insulin receptor	Homo sapiens	48-64	
27743890-9	2016	Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4.	Simvastatin	0-11	insulin receptor	Homo sapiens	64-66	
27470565-5	2016	Mechanistically, the inhibition of glucose uptake and GLUT4 translocation elicited by simvastatin were associated with the suppression of the insulin receptor (IR)/IR substrate (IRS)/Akt signaling cascade.	Simvastatin	86-97	insulin receptor	Homo sapiens	142-158	
27470565-5	2016	Mechanistically, the inhibition of glucose uptake and GLUT4 translocation elicited by simvastatin were associated with the suppression of the insulin receptor (IR)/IR substrate (IRS)/Akt signaling cascade.	Simvastatin	86-97	insulin receptor	Homo sapiens	160-162	
27470565-6	2016	Simvastatin suppressed the phosphorylation of IR, IRS-1 and Akt, and total expression of IR or IRS-1, but did not affect Akt.	Simvastatin	0-11	insulin receptor	Homo sapiens	46-48	
27470565-6	2016	Simvastatin suppressed the phosphorylation of IR, IRS-1 and Akt, and total expression of IR or IRS-1, but did not affect Akt.	Simvastatin	0-11	insulin receptor	Homo sapiens	50-52	
27470565-8	2016	In conclusion, our findings indicate that simvastatin suppresses glucose uptake activity and GLUT4 translocation via IR-dependent IRS-1/PI3K/Akt pathway.	Simvastatin	42-53	insulin receptor	Homo sapiens	117-119