PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19816600-7	2009	When simvastatin or EGF was added to HG-treated LECs, caveolin-1 levels increased and the apoptosis rate of LECs decreased.	Simvastatin	5-16	caveolin 1	Homo sapiens	54-64	
31081050-0	2019	Simvastatin delays castration-resistant prostate cancer metastasis and androgen receptor antagonist resistance by regulating the expression of caveolin-1.	Simvastatin	0-11	caveolin 1	Homo sapiens	143-153	
31081050-8	2019	Importantly, simvastatin was able to augment the anticancer effects of androgen receptor antagonists by downregulating the expression of Cav-1.	Simvastatin	13-24	caveolin 1	Homo sapiens	137-142	
22792801-7	2012	They could enhance the NO content in cell culture supernatants, down-regulate the expression of Cav-1 and up-regulate the expression of eNOS at mRNA and protein levels, which was especially notable after treatment with serum containing TYTZF and simvastatin in large doses.	Simvastatin	246-257	caveolin 1	Homo sapiens	96-101	
19934968-9	2009	Simvastatin also decreased cholesterol content in lipid raft fractions, suppressed caveolin-1 expression in the lipid rafts, and induced Fas translocation into lipid rafts, suggesting that simvastatin may inhibit the prosurvival PI3K/Akt pathway and trigger caspase-3-dependent apoptotic cell death through the modulation of lipid rafts.	Simvastatin	0-11	caveolin 1	Homo sapiens	83-93	
19934968-9	2009	Simvastatin also decreased cholesterol content in lipid raft fractions, suppressed caveolin-1 expression in the lipid rafts, and induced Fas translocation into lipid rafts, suggesting that simvastatin may inhibit the prosurvival PI3K/Akt pathway and trigger caspase-3-dependent apoptotic cell death through the modulation of lipid rafts.	Simvastatin	189-200	caveolin 1	Homo sapiens	83-93	
29549671-0	2018	Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin.	Simvastatin	146-157	caveolin 1	Homo sapiens	16-26	
29549671-1	2018	This study was undertaken to verify whether simvastatin modulates Cav-1/eNOS expression, and if this modulation is associated with changes in pro- and anti-inflammatory cytokine and Toll-like receptor 4 (TLR4) level in abdominal aortic aneurysm (AAA).	Simvastatin	44-55	caveolin 1	Homo sapiens	66-71	
29549671-3	2018	Simvastatin treatment decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the AAA wall.	Simvastatin	0-11	caveolin 1	Homo sapiens	32-37	
29549671-5	2018	The changes in Cav-1 and eNOS were associated with a trend towards decreased IL-6 and IL-17 concentration (p>0.05) and increased IL-10 concentration (p=0.055); however, TLR4 expression was unaffected, suggesting that simvastatin influences Cav-1 and eNOS in the AAA wall by other mechanisms.	Simvastatin	220-231	caveolin 1	Homo sapiens	15-20	
29549671-6	2018	Simvastatin may modulate Cav-1 and eNOS expression in the aneurysmal wall, indicating a potentially beneficial role for statins in AAA patients.	Simvastatin	0-11	caveolin 1	Homo sapiens	25-30	
24932304-0	2014	Enhanced antitumor effects of low-frequency ultrasound and microbubbles in combination with simvastatin by downregulating caveolin-1 in prostatic DU145 cells.	Simvastatin	92-103	caveolin 1	Homo sapiens	122-132	
24932304-15	2014	The expression of caveolin-1 was lowest in the LFUM combined with simvastatin treatment group.	Simvastatin	66-77	caveolin 1	Homo sapiens	18-28	
24932304-17	2014	The results indicate that LFUM in combination with simvastatin may additively or synergistically inhibit cell viability and induce apoptosis of DU145 cells by downregulating caveolin-1 and p-Akt protein expression.	Simvastatin	51-62	caveolin 1	Homo sapiens	174-184	
22796581-9	2012	Simvastatin increased NO production, the expression of eNOS and phosphorylation at serine1177, phosphorylation of Akt, expression of heat shock protein 90, heat shock protein 90 association with eNOS and decreased eNOS phosphorylation at threonine 495, phosphorylation of p38, and expression of caveolin-1.	Simvastatin	0-11	caveolin 1	Homo sapiens	295-305