PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23941814-0	2013	Simvastatin enhances the chemotherapeutic efficacy of S-1 against bile duct cancer: E2F-1/TS downregulation might be the mechanism.	Simvastatin	0-11	thymidylate synthetase	Homo sapiens	90-92	
23941814-9	2013	Simvastatin alone or plus 5-FU significantly suppressed E2F-1 and TS expressions in EGI-1 and MZ-ChA-1.	Simvastatin	0-11	thymidylate synthetase	Homo sapiens	66-68	
23941814-11	2013	Simvastatin plus S-1 induced greater tumor inhibition than simvastatin or S-1 alone with E2F-1/TS downregulation in vivo (all P < 0.05).	Simvastatin	0-11	thymidylate synthetase	Homo sapiens	95-97	
23941814-12	2013	Simvastatin and S-1 exerted synergistic effects against bile duct cancer, which might be mediated by E2F-1/TS downregulation.	Simvastatin	0-11	thymidylate synthetase	Homo sapiens	107-109	
17428261-10	2007	Of down-regulated genes induced by simvastatin treatment, a significant depletion of thymidylate synthase was confirmed using western blot analysis.	Simvastatin	35-46	thymidylate synthetase	Homo sapiens	85-105