PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22939729-7	2012	Simvastatin reduced IL-1beta and IL-6 mRNA expressions in the uterus, IL-6 and tumor necrosis factor alpha (TNF-alpha) in the cervix, and IL-1beta, IL-2, IL-12p70, IL-13, TNF-alpha, GM-CSF, and interferon-gamma concentrations in the serum and IL-6 in AF.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	20-28	
22939729-7	2012	Simvastatin reduced IL-1beta and IL-6 mRNA expressions in the uterus, IL-6 and tumor necrosis factor alpha (TNF-alpha) in the cervix, and IL-1beta, IL-2, IL-12p70, IL-13, TNF-alpha, GM-CSF, and interferon-gamma concentrations in the serum and IL-6 in AF.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	138-146	
22683568-7	2012	Finally, although simvastatin (20 mg/kg) conferred significant protection in murine ALI as evidenced by decreased bronchoalveolar lavage fluid cell counts, protein, inflammatory cytokines (IL-6, IL-1beta, MCP-1, RANTES), decreased Evans blue dye albumin extravasation in lung tissue, and changes on lung histology, these effects were reversed by the integrin-beta4-blocking antibody (IV, 1 mg/kg, 2 h before LPS).	Simvastatin	18-29	interleukin 1 beta	Mus musculus	195-203	
29752615-12	2018	Simvastatin reduced plasma levels of presepsin, IL-1beta, and IL-6.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	48-56	
30644168-6	2019	Attenuation of OA in mice treated with simvastatin-conjugated gelatin hydrogel was associated with decreased expression of cartilage-degrading enzymes and interleukin (IL)-1beta and increased expression of type II collagen and an autophagic marker, LC3, in the articular cartilage.	Simvastatin	39-50	interleukin 1 beta	Mus musculus	155-177	
30644168-8	2019	Treatment with simvastatin down-regulated Mmp-13 and Il-1beta and up-regulated Col2a1 and autophagic activity.	Simvastatin	15-26	interleukin 1 beta	Mus musculus	53-61	
30699879-8	2019	Moreover, simvastatin markedly prevented and ameliorated LPS and CMS-induced neuroinflammation, as shown by the suppressed activation of microglia in hippocampus and decreased hippocampal pro-inflammatory cytokines expressions including IL-1beta, TNF-alpha, IL-6, which might be mediated via the inhibition of NF-kappaB pathway, as shown by the decreased nuclear NF-kappaB p65 expression.	Simvastatin	10-21	interleukin 1 beta	Mus musculus	237-245	
31949780-10	2018	We found that simvastatin treatment could significantly inhibit inflammation by modulating the expression of mediators, such as IL-1beta, TNF-alpha and IL-6, whose expression were increased remarkably in the activated RAW264.7 cells.	Simvastatin	14-25	interleukin 1 beta	Mus musculus	128-136