PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30312114-4	2019	We show that simvastatin reduced the incidence of PTB in a validated intrauterine LPS-induced PTB mouse model, decreased uterine proinflammatory mRNA concentrations (IL-6, Cxcl1, and Ccl2), and reduced serum IL-6 concentration.	Simvastatin	13-24	chemokine (C-C motif) ligand 2	Mus musculus	183-187	
35618653-7	2022	They greatly inhibited the M1-type polarization of macrophages; reduced intracellular reactive oxygen species level and inflammatory cytokine; and TNF-alpha, MCP-1, and IL-1beta were secreted by macrophage cells, thus providing enhanced anti-inflammatory and antioxidant effects compared with free simvastatin.	Simvastatin	298-309	chemokine (C-C motif) ligand 2	Mus musculus	158-163	
27021071-7	2016	Finally, simvastatin inhibited production of monocyte chemoattractant protein-1 (MCP-1) and other inflammatory cytokines following LPS stimulation and reduced monocyte chemotaxis in response to MCP-1, a major driver of myeloid cell accumulation in the CNS in HAND.	Simvastatin	9-20	chemokine (C-C motif) ligand 2	Mus musculus	45-79	
28758631-13	2017	In contrast, simvastatin therapy did not reduce any of the tested genes, but did slightly increase the expression of Ccl2 and Cxcl13.	Simvastatin	13-24	chemokine (C-C motif) ligand 2	Mus musculus	117-121	
27021071-7	2016	Finally, simvastatin inhibited production of monocyte chemoattractant protein-1 (MCP-1) and other inflammatory cytokines following LPS stimulation and reduced monocyte chemotaxis in response to MCP-1, a major driver of myeloid cell accumulation in the CNS in HAND.	Simvastatin	9-20	chemokine (C-C motif) ligand 2	Mus musculus	81-86	
27021071-7	2016	Finally, simvastatin inhibited production of monocyte chemoattractant protein-1 (MCP-1) and other inflammatory cytokines following LPS stimulation and reduced monocyte chemotaxis in response to MCP-1, a major driver of myeloid cell accumulation in the CNS in HAND.	Simvastatin	9-20	chemokine (C-C motif) ligand 2	Mus musculus	194-199	
22583375-7	2012	RESULTS: We found that simvastatin had differential effects on IL-13-mediated gene expression (inhibited eotaxin-1; MCP-1,-2,-3; and osteopontin (SPP1), while it induced caspase-1 and CCL20 (MIP-3alpha)) in MTE cells.	Simvastatin	23-34	chemokine (C-C motif) ligand 2	Mus musculus	116-121	
23564080-11	2013	Administration with simvastatin in ApoE(-/-) mice markedly attenuated the vascular inflammation and atherosclerotic lesion area, and decreased the aortic expression of HMGB1, RAGE, VCAM-1, and MCP-1.	Simvastatin	20-31	chemokine (C-C motif) ligand 2	Mus musculus	193-198	
22683568-7	2012	Finally, although simvastatin (20 mg/kg) conferred significant protection in murine ALI as evidenced by decreased bronchoalveolar lavage fluid cell counts, protein, inflammatory cytokines (IL-6, IL-1beta, MCP-1, RANTES), decreased Evans blue dye albumin extravasation in lung tissue, and changes on lung histology, these effects were reversed by the integrin-beta4-blocking antibody (IV, 1 mg/kg, 2 h before LPS).	Simvastatin	18-29	chemokine (C-C motif) ligand 2	Mus musculus	205-210	
22267540-5	2012	In mouse model, simvastatin decreased MCP-1 expression in a dose-dependent manner in endometriotic implants (P < .05).	Simvastatin	16-27	chemokine (C-C motif) ligand 2	Mus musculus	38-43	
22267540-6	2012	Similarly, both simvastatin and mevastatin revealed a dose-dependent inhibition of MCP-1 production in cultured endometriotic cells (P < .01).	Simvastatin	16-27	chemokine (C-C motif) ligand 2	Mus musculus	83-88	
16321392-6	2006	First, we have shown by ELISA that 1 microM simvastatin significantly reduced MCP-1 in endothelial cells (ECs) and macrophages stimulated with TNF-alpha or IFN-gamma, respectively.	Simvastatin	44-55	chemokine (C-C motif) ligand 2	Mus musculus	78-83	
12818400-8	2003	RNA levels for MCP-1 were reduced to 30% of control values following 24 weeks of simvastatin treatment.	Simvastatin	81-92	chemokine (C-C motif) ligand 2	Mus musculus	15-20	
15781755-8	2005	Treatment of C57/BL6 mice with simvastatin (0.2 microg/g body weight IP, daily for 1 week) inhibited transmigration of CD80+ monocytes to the MCP-1-injected intraperitoneal space.	Simvastatin	31-42	chemokine (C-C motif) ligand 2	Mus musculus	142-147