PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8835365-1	1995	The present study analyses the effects of simvastatin, a specific inhibitor of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA reductase) in male Syrian hamsters fed a standard diet or a diet supplemented with 0.12% cholesterol and 20% coconut oil.	Simvastatin	42-53	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	122-139	
8835365-7	1995	The toxicity of simvastatin could indeed result from the low basal activity of HMG-CoA reductase in hamster liver coupled with a prolonged inhibition of mevalonate synthesis.	Simvastatin	16-27	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	79-96	
9763219-0	1998	Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4"-(6-allyl-ethyl-amino-hexyloxy)-2"-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin.	Simvastatin	269-280	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	19-66	
9763219-7	1998	In contrast, simvastatin, at concentrations inhibiting cholesterol synthesis by the same 50-75%, increased both HMGR mRNA levels and synthesis, as well as LDL uptake.	Simvastatin	13-24	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	112-116	
9763219-9	1998	Still, simvastatin markedly increased both HMGR mRNA levels and synthesis in cells incubated in the presence of LDL, leaving LDL uptake unaffected.	Simvastatin	7-18	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	43-47