PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19299917-9 2009 Simvastatin attenuated CSE-mediated activation of RAS and phosphorylation of ERK, Akt, p65, IkappaB, and nuclear AP-1 or NF-kappaB activity. Simvastatin 0-11 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 113-117 19299917-10 2009 Taken together, these results suggest that simvastatin may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of RAS in the signaling pathways, in which Raf-MEK-ERK, PI3K/Akt, AP-1, and IkappaB-NF-kappaB are involved. Simvastatin 43-54 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 197-201