PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15508788-3	2004	In presented work the influence of acetylsalicylic acid, metoprolol, simvastatin, isosorbide mononitrate and molsidomine on total activity of adenosine deaminase and its isoenzymes--ADA1 and ADA2 in vivo was studied.	Simvastatin	69-80	adenosine deaminase	Homo sapiens	142-161	
27557561-0	2016	Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism.	Simvastatin	0-11	adenosine deaminase	Homo sapiens	25-44	
27557561-4	2016	METHODS: We extended a previous randomized double-blind placebo crossover study to investigate the effects of simvastatin (20 mg/day) on sputum ADA and OPN expression and explored the underlying signaling pathways involved by conducting in vitro experiments with cigarette smoke extract (CSE)-treated monocyte-derived macrophages (MDM) from COPD patients and healthy subjects.	Simvastatin	110-121	adenosine deaminase	Homo sapiens	144-147	
27557561-5	2016	RESULTS: Simvastatin decreased sputum IL-13, OPN and CD73, while increasing ADA expression, irrespective of inhaled corticosteroid treatment and smoking status in parallel to increased inosine levels.	Simvastatin	9-20	adenosine deaminase	Homo sapiens	76-79	
27557561-6	2016	The degree of simvastatin-restored ADA activity was significantly correlated with the magnitude of changes in pre-bronchodilator FEV1.	Simvastatin	14-25	adenosine deaminase	Homo sapiens	35-38	
27557561-8	2016	Simvastatin treatment inhibited IL-13 transcription in a dose-dependent manner, and therefore diminished the IL-13-induced increase in OPN and restored IL-13-suppressed ADA.	Simvastatin	0-11	adenosine deaminase	Homo sapiens	169-172	
27557561-10	2016	CONCLUSION: Simvastatin reversed IL-13-suppressed ADA activity that leads to the down-regulation of adenosine signaling and therefore inhibits OPN expression through the direct inhibition of IL-13-activated STAT6 pathway.	Simvastatin	12-23	adenosine deaminase	Homo sapiens	50-53