PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15508788-3 2004 In presented work the influence of acetylsalicylic acid, metoprolol, simvastatin, isosorbide mononitrate and molsidomine on total activity of adenosine deaminase and its isoenzymes--ADA1 and ADA2 in vivo was studied. Simvastatin 69-80 adenosine deaminase Homo sapiens 142-161 27557561-0 2016 Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism. Simvastatin 0-11 adenosine deaminase Homo sapiens 25-44 27557561-4 2016 METHODS: We extended a previous randomized double-blind placebo crossover study to investigate the effects of simvastatin (20 mg/day) on sputum ADA and OPN expression and explored the underlying signaling pathways involved by conducting in vitro experiments with cigarette smoke extract (CSE)-treated monocyte-derived macrophages (MDM) from COPD patients and healthy subjects. Simvastatin 110-121 adenosine deaminase Homo sapiens 144-147 27557561-5 2016 RESULTS: Simvastatin decreased sputum IL-13, OPN and CD73, while increasing ADA expression, irrespective of inhaled corticosteroid treatment and smoking status in parallel to increased inosine levels. Simvastatin 9-20 adenosine deaminase Homo sapiens 76-79 27557561-6 2016 The degree of simvastatin-restored ADA activity was significantly correlated with the magnitude of changes in pre-bronchodilator FEV1. Simvastatin 14-25 adenosine deaminase Homo sapiens 35-38 27557561-8 2016 Simvastatin treatment inhibited IL-13 transcription in a dose-dependent manner, and therefore diminished the IL-13-induced increase in OPN and restored IL-13-suppressed ADA. Simvastatin 0-11 adenosine deaminase Homo sapiens 169-172 27557561-10 2016 CONCLUSION: Simvastatin reversed IL-13-suppressed ADA activity that leads to the down-regulation of adenosine signaling and therefore inhibits OPN expression through the direct inhibition of IL-13-activated STAT6 pathway. Simvastatin 12-23 adenosine deaminase Homo sapiens 50-53