PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15488325-6	2004	In immunocytochemical and immunoblotting experiments we have shown that simvastatin markedly increased the phosphorylation of ATF-2 and c-jun in the nucleus of the C6 glioma cells at early time points which was preserved even 24 h after treatment.	Simvastatin	72-83	activating transcription factor 2	Homo sapiens	126-131	
15488325-8	2004	Selective inhibitor of JNK, but not p38 kinase, reduced simvastatin-induced cell death and ATF-2 and c-jun phosphorylation suggesting that JNK-dependent activation of ATF-2 and c-jun may play an important role in simvastatin-induced proliferation inhibition and apoptosis in C6 glioma cells.	Simvastatin	56-67	activating transcription factor 2	Homo sapiens	167-172	
15488325-8	2004	Selective inhibitor of JNK, but not p38 kinase, reduced simvastatin-induced cell death and ATF-2 and c-jun phosphorylation suggesting that JNK-dependent activation of ATF-2 and c-jun may play an important role in simvastatin-induced proliferation inhibition and apoptosis in C6 glioma cells.	Simvastatin	213-224	activating transcription factor 2	Homo sapiens	167-172	
25316568-0	2014	Simvastatin induces NFkappaB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells.	Simvastatin	0-11	activating transcription factor 2	Homo sapiens	64-69	
25316568-12	2014	Taken together, our data indicate that simvastatin-induced p65 instability leads to MMP-9 down-regulation in leukemia cells, while simvastatin-induced JNK1/c-Jun/ATF-2 activation maintains the MMP-2 expression underlying p65 down-regulation.	Simvastatin	131-142	activating transcription factor 2	Homo sapiens	162-167	
25316568-4	2014	Meanwhile, simvastatin induced JNK-mediated c-Jun and ATF-2 activation.	Simvastatin	11-22	activating transcription factor 2	Homo sapiens	54-59	
25316568-7	2014	Simvastatin enhanced the binding of c-Jun/ATF-2 with the MMP-2 promoter.	Simvastatin	0-11	activating transcription factor 2	Homo sapiens	42-47