PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2776246-1	1989	Relatively high concentrations of MK-733 (simvastatin) and MK-803 (lovastatin, mevinolin), which are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, were found to inhibit acyl coenzyme A: cholesterol acyltransferase (ACAT) of rabbit intestinal microsomes with IC50"s of 2.0 x 10(-5) and 3.6 x 10(-5) M, respectively.	Simvastatin	34-40	sterol O-acyltransferase 1	Oryctolagus cuniculus	239-243	
2742865-5	1989	To clarify the mechanism of action, the effects of MK-733 on acyl coenzyme A:cholesterol acyltransferase (ACAT) and cholesterol esterase activities, which are thought to participate in the absorption of cholesterol, were examined.	Simvastatin	51-57	sterol O-acyltransferase 1	Oryctolagus cuniculus	106-110	
2742865-7	1989	10 mg/kg) of MK-733 to cholesterol-fed rabbits was found to inhibit the increase in serum total cholesterol levels, and caused a 70% reduction in ACAT activity in microsomes of intestinal mucosa relative to those observed in concurrent control rabbits.	Simvastatin	13-19	sterol O-acyltransferase 1	Oryctolagus cuniculus	146-150	
2742865-9	1989	The inhibitory effect of MK-733 on cholesterol absorption in cholesterol-fed rabbits is though to be related to a reduction in microsomal ACAT activity in the intestinal mucosa.	Simvastatin	25-31	sterol O-acyltransferase 1	Oryctolagus cuniculus	138-142	
2776246-3	1989	A kinetic analysis using a Lineweaver-Burk plot indicated that MK-733 is a competitive inhibitor of ACAT, with a Ki value of 1.2 x 10(-5) M.	Simvastatin	63-69	sterol O-acyltransferase 1	Oryctolagus cuniculus	100-104