PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32016638-10 2020 Simvastatin reversed the NMDAR2B increase, restored Nur77 downward, and reduced the expression of COX-2 and TNF-alpha in MPTP-treated mice. Simvastatin 0-11 nuclear receptor subfamily 4, group A, member 1 Mus musculus 52-57 32016638-11 2020 This role of simvastatin was consistent with MK801 in increasing the expression of Nur77 and inhibiting NMDAR2B and cytokines in MPTP-lesioned PD mice. Simvastatin 13-24 nuclear receptor subfamily 4, group A, member 1 Mus musculus 83-88 32016638-12 2020 These findings suggest that reversed the NMDAR2B increase, restored Nur77 downward, and reduced the expression of COX-2 and TNF-alpha in MPTP-treated mice may be one of the mechanisms that simvastatin improves cognitive functions, depression, and anxiety in MPTP-lesioned mice. Simvastatin 189-200 nuclear receptor subfamily 4, group A, member 1 Mus musculus 68-73 24851101-0 2014 The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages. Simvastatin 90-101 nuclear receptor subfamily 4, group A, member 1 Mus musculus 28-33 24851101-3 2014 Here, we show that the nuclear orphan receptor NR4A1 is involved in a caspase-independent apoptotic process induced by LPS and simvastatin. Simvastatin 127-138 nuclear receptor subfamily 4, group A, member 1 Mus musculus 47-52 24851101-4 2014 Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. Simvastatin 0-11 nuclear receptor subfamily 4, group A, member 1 Mus musculus 20-25 24851101-4 2014 Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. Simvastatin 0-11 nuclear receptor subfamily 4, group A, member 1 Mus musculus 123-128 24851101-4 2014 Simvastatin-induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant-negative mutant form of NR4A1 effectively suppressed both DNA fragmentation and the disruption of mitochondrial membrane potential (MMP) during LPS- and simvastatin-induced apoptosis. Simvastatin 252-263 nuclear receptor subfamily 4, group A, member 1 Mus musculus 123-128 24851101-6 2014 Our findings suggest that NR4A1 expression and mitochondrial translocation of Bax are related to simvastatin-induced apoptosis in LPS-activated RAW 264.7 macrophages. Simvastatin 97-108 nuclear receptor subfamily 4, group A, member 1 Mus musculus 26-31