PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16051523-1 2005 The in vitro effect of the hydrophilic statin - pravastatin - and three hydrophobic statins - atorvastatin, lovastatin and simvastatin - on the production of IL-1beta, IL-1ra, IL-2, IL-6 and IFN-gamma by human peripheral blood mononuclear cells (PBMC) and their response to mitogens was examined. Simvastatin 123-134 interleukin 1 receptor antagonist Homo sapiens 168-174 21440087-3 2011 The secretion of the pro-inflammatory cytokines IL-1beta and IFNgamma and that of the anti-inflammatory cytokines IL-1ra and IL-10 induced by cancer cells was decreased by simvastatin but not by pravastatin, whereas that of IL-6 was not affected by both drugs. Simvastatin 172-183 interleukin 1 receptor antagonist Homo sapiens 114-120 16051523-2 2005 Lovastatin and simvastatin increased the production of IL-1beta in a dose dependent manner and reduced secretion of IL-1ra at high concentration. Simvastatin 15-26 interleukin 1 receptor antagonist Homo sapiens 116-122