PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29022140-4 2018 Treatment with simvastatin demonstrated significant decreases in the concentration of protein, TNF-alpha, IL-1beta, IL-6, and lipocalin 2, and the number of polymorphonuclear neutrophils in bronchoalveolar lavage fluid in septic rats. Simvastatin 15-26 interleukin 6 Rattus norvegicus 116-120 30274910-9 2019 Furthermore, simvastatin pretreatment affected superoxide dismutase and malondialdehyde activities (P < 0.05) to reduce oxidative stress, and inhibited levels of high-mobility group box-1, CD68, toll-like receptor 4, tumor necrosis factor alpha, interleukin-1beta and interleukin-6 (P < 0.05) to suppress inflammatory response. Simvastatin 13-24 interleukin 6 Rattus norvegicus 268-281 30463769-8 2018 In addition, simvastatin effectively reduced the intestinal levels of tumor necrosis factor alpha, interleukin-6, high-mobility group box 1, and malondialdehyde and increased the activity of superoxide dismutase in rats with sepsis. Simvastatin 13-24 interleukin 6 Rattus norvegicus 99-112 32524380-7 2020 Simvastatin-treated rats that survived to sepsis showed a reduction in the levels of nitrate, IL1-beta, and IL-6 and an increase in Bcl-2 protein expression in the prefrontal cortex and hippocampus, and synaptophysin only in the hippocampus. Simvastatin 0-11 interleukin 6 Rattus norvegicus 108-112 32242391-10 2020 Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-kappaB, NLRP3, ASC, caspase-1, IL-1beta, and IL-6 (all P < 0.01). Simvastatin 5-16 interleukin 6 Rattus norvegicus 158-162 30767945-9 2019 Simvastatin decreased the protein expressions of VCAM-1, ICAM-1, IL-6, and TNF-alpha, increased eNOS protein expression, and limited an increase in ROS levels in the heart tissue. Simvastatin 0-11 interleukin 6 Rattus norvegicus 65-69 28800541-8 2017 Levels of TNF-alpha, IL-1beta, IL-6, MCP-1 and NO in myocardial tissues, together with levels of CTnI in serum were significantly declined in simvastatin-treated rats. Simvastatin 142-153 interleukin 6 Rattus norvegicus 31-35 28915536-11 2017 Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta. Simvastatin 14-25 interleukin 6 Rattus norvegicus 179-183 27796742-9 2017 The CLP rats treated with simvastatin showed a reduction in nitric oxide (P < 0.05), IL1-beta (P < 0.001), IL-6 (P < 0.01), and TBARS levels (P < 0.001) and an increase in catalase activity (P < 0.01), citrate synthase enzyme (P < 0.05), and normalized GSH/GSSG ratio. Simvastatin 26-37 interleukin 6 Rattus norvegicus 113-117 24493323-3 2014 Monotherapy with simvastatin or ezetimibe and the ezetimibe + simvastatin combination effectively reduced the cytokine levels (interleukin-6 and tumor necrosis factor) and articular lesions that are characteristic of this experimental disease. Simvastatin 17-28 interleukin 6 Rattus norvegicus 127-140 28456771-7 2017 Simvastatin treatment reduced the mRNA levels of interleukin-6 and interleukin-8 by approximately 50% in TNF-alpha-stimulated IEC-6 cells. Simvastatin 0-11 interleukin 6 Rattus norvegicus 49-62 26307750-12 2016 In the simvastatin group and the icariin groups, the serum levels of IL-6 and TNF-alpha and the related tissue mRNA levels, as well as the expression of p-p38 MAPK, were markedly reduced compared with the AS group. Simvastatin 7-18 interleukin 6 Rattus norvegicus 69-73 24493323-3 2014 Monotherapy with simvastatin or ezetimibe and the ezetimibe + simvastatin combination effectively reduced the cytokine levels (interleukin-6 and tumor necrosis factor) and articular lesions that are characteristic of this experimental disease. Simvastatin 62-73 interleukin 6 Rattus norvegicus 127-140 19595129-10 2009 The perivascular inflammation score of the simvastatin intervention group was (2.19 +/- 0.81), significantly lower than that of the PH group (3.40 +/- 0.65, P < 0.05), and the IL-6, TNF-alpha, and MCP-1 levels of the simvastatin intervention group [(264 +/- 127), (179 +/- 91), and (697 +/- 211) pg/ml respectively] were all significantly lower than those of the PH group [(765 +/- 179), (447 +/- 86), (4428 +/- 757) pg/ml respectively, all P < 0.01]. Simvastatin 43-54 interleukin 6 Rattus norvegicus 179-183 24482148-9 2014 The 6-OHDA-stimulated mRNA and protein levels of the proinflammatory cytokines NMDAR1, TNF-alpha, IL-1beta, and IL-6 were reduced by simvastatin. Simvastatin 133-144 interleukin 6 Rattus norvegicus 112-116 24372369-9 2014 Simvastatin significantly reduced serum level of CRP and exudates levels of TNF-alpha, IL-6 and MDA as well as significantly elevated exudates level of NO and IL-4. Simvastatin 0-11 interleukin 6 Rattus norvegicus 87-91 24372369-12 2014 The anti-inflammatory effects of simvastatin are comparable to aspirin and their combination may produce better effects especially in the attenuation of the oxidative stress and IL-6. Simvastatin 33-44 interleukin 6 Rattus norvegicus 178-182 23279934-6 2013 RESULTS: Simvastatin-mediated neuroprotection was associated with a robust reduction in the upregulation induced by 6-OHDA of inflammatory mediators including IL-6, COX2, and TNF-alpha. Simvastatin 9-20 interleukin 6 Rattus norvegicus 159-163 23838355-8 2013 The IL-6 levels in the 10 and 20 mg/kg/d simvastatin groups were lower than those of the controls (p = 0.005 and p = 0.008). Simvastatin 41-52 interleukin 6 Rattus norvegicus 4-8 21867382-9 2011 In addition, perivascular infiltration of inflammatory cells and the level of IL-6 were decreased in simvastatin treatment group. Simvastatin 101-112 interleukin 6 Rattus norvegicus 78-82 20414574-10 2010 Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were lower in diabetic and non diabetics septic rats treated with simvastatin, than after saline treatment. Simvastatin 171-182 interleukin 6 Rattus norvegicus 37-41 19166837-7 2009 As a result, we found that treatment with simvastatin markedly inhibited the mRNA and protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Simvastatin 42-53 interleukin 6 Rattus norvegicus 244-257 19166837-7 2009 As a result, we found that treatment with simvastatin markedly inhibited the mRNA and protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Simvastatin 42-53 interleukin 6 Rattus norvegicus 259-263 24455299-17 2013 Simvastatin significantly counteracted the increase in myocardium level of TNF- alpha , IL-1B, IL-6, MCP-1 and MIP-1 alpha , plasma cTnI, and apoptosis (P < 0.05). Simvastatin 0-11 interleukin 6 Rattus norvegicus 95-99 22305382-10 2012 At 10 days, simvastatin significantly attenuated the production of pro-inflammatory cytokines, IL-1beta, TNF-alpha, MCP-1 and IP-10, and Th17-polarizing cytokines, IL-6 and IL-17e, and inhibited allograft infiltration by inflammatory cells. Simvastatin 12-23 interleukin 6 Rattus norvegicus 164-168 20128155-1 2009 OBJECTIVE: The objective of this study was to investigate the effect of simvastatin on TLR4,TNF-alpha and IL-6 expression in the myocardium and its relation to left ventricular (LV) remodelling in a rat model of myocardial infarction (MI) and to investigate the mechanism by which simvastatin improves LV remodelling in rats after MI. Simvastatin 72-83 interleukin 6 Rattus norvegicus 106-110 20128155-6 2009 The expression of TLR4, TNF-alpha and IL-6 in the myocardium significantly increased in the MI group and simvastatin markedly inhibits the expression of TLR4, TNF-alpha, and IL-6 in the myocardium after MI. Simvastatin 105-116 interleukin 6 Rattus norvegicus 174-178 20128155-8 2009 Both in the MI group and the simvastatin group,TLR4 protein positively related to LVEDD and to the levels of TNF-alpha and IL-6 in the myocardium, respectively. Simvastatin 29-40 interleukin 6 Rattus norvegicus 123-127 19595129-11 2009 CONCLUSION: The protective effects of simvastatin against MCT-induced PH may be associated with the inhibition of the perivascular inflammation and lung IL-6, TNF-alpha, and MCP-1 levels. Simvastatin 38-49 interleukin 6 Rattus norvegicus 153-157 18036927-8 2007 The levels of interleukin-6, tumor necrosis factor-alpha, and monocyte chemotactic protein-1 in serum, bronchoalveolar lavage fluid, and lung tissues increased in CPB groups, whereas pretreatment with simvastatins reduced these inflammatory marks in a dose-dependent manner (p < 0.01, versus control group). Simvastatin 201-213 interleukin 6 Rattus norvegicus 14-56 15883752-8 2005 Simvastatin markedly attenuated the production of TNF-alpha, IL-1beta, IL-6 and increased IL-10 levels in the noninfarcted and infarcted regions, reduced collagen deposition in the noninfarcted myocardium and improved left ventricular function. Simvastatin 0-11 interleukin 6 Rattus norvegicus 71-75